Interleukins in the pathogenesis of influenza and other acute respiratory viral infections.

IF 2.5 4区 医学 Q3 INFECTIOUS DISEASES Epidemiology and Infection Pub Date : 2024-09-30 DOI:10.1017/S0950268824001109
Mykchaylo Andreychyn, Larysa Melnyk, Nataliia Zavidniiuk, Natalya Nychyk, Iaryna Iosyk
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Abstract

Influenza and other acute respiratory viral infections (ARVIs) are among the most common human diseases. In recent decades, the discovery of cytokines and their significance in the pathogenesis of diseases has led to extensive research on these compounds in various pathologies including ARVIs. The aim of the research was to study the cytokine profile in patients with ARVIs. The cases of 30 patients were investigated. Etiological diagnosis was performed by polymerase chain reaction. Different classes of cytokines in the serum were defined by the enzyme-linked immunosorbent assay (ELISA). The level of cytokines depended on the number of pathogens. The highest levels of pro-inflammatory interleukins and the lowest levels of anti-inflammatory IL-4 were observed in patients with a combination of five or more viruses compared to those with a monoinfection. Analysis of the data showed that in the acute phase, the levels of all studied pro-inflammatory cytokines - IL-2, IL-6, and TNF-α - increased by 8, 39, and 9 times, respectively, compared to those in healthy individuals. In the acute phase of ARVI, the levels of pro-inflammatory cytokines were significantly higher and depended on the severity of the disease. The imbalance of cytokines in the serum has been established in cases of ARVIs, depending on the severity of the disease.

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流感和其他急性呼吸道病毒感染发病机制中的白细胞介素。
流感和其他急性呼吸道病毒感染(ARVI)是人类最常见的疾病之一。近几十年来,由于发现了细胞因子及其在疾病发病机制中的重要作用,人们对这些化合物在包括急性呼吸道病毒感染在内的各种病症中的作用进行了广泛研究。这项研究的目的是研究 ARVI 患者的细胞因子谱。对 30 名患者的病例进行了调查。病因诊断通过聚合酶链反应进行。通过酶联免疫吸附试验(ELISA)确定了血清中不同种类的细胞因子。细胞因子的水平取决于病原体的数量。与单一病毒感染者相比,合并感染五种或更多病毒的患者体内促炎性白细胞介素的水平最高,而抗炎性 IL-4 的水平最低。数据分析显示,在急性期,所有研究的促炎细胞因子--IL-2、IL-6 和 TNF-α --的水平与健康人相比分别增加了 8 倍、39 倍和 9 倍。在急性阿尔茨海默病的急性期,促炎细胞因子的水平明显较高,并取决于疾病的严重程度。在阿尔茨海默病病例中,血清中细胞因子的失衡已被证实,这取决于疾病的严重程度。
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来源期刊
Epidemiology and Infection
Epidemiology and Infection 医学-传染病学
CiteScore
4.10
自引率
2.40%
发文量
366
审稿时长
3-6 weeks
期刊介绍: Epidemiology & Infection publishes original reports and reviews on all aspects of infection in humans and animals. Particular emphasis is given to the epidemiology, prevention and control of infectious diseases. The scope covers the zoonoses, outbreaks, food hygiene, vaccine studies, statistics and the clinical, social and public-health aspects of infectious disease, as well as some tropical infections. It has become the key international periodical in which to find the latest reports on recently discovered infections and new technology. For those concerned with policy and planning for the control of infections, the papers on mathematical modelling of epidemics caused by historical, current and emergent infections are of particular value.
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