Computational Designed and Optimized Liposomal Curcumin-Embedded Bifunctional Cross-Linked Hydrogels for Wound Healing.

IF 5 3区化学 Q1 POLYMER SCIENCE Gels Pub Date : 2024-09-18 DOI:10.3390/gels10090598

Chaiyakarn Pornpitchanarong, Khin Cho Aye, Kwanputtha Arunprasert, Praneet Opanasopit, Prasopchai Patrojanasophon

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Abstract

Curcumin (CUR) bifunctional cross-linked nanocomposite hydrogels are presented as an efficient method for CUR delivery in wound healing. CUR-loaded liposomes (CUR-Ls) were optimized using the Box-Behnken design to augment particle size, size distribution, zeta potential, and CUR concentration. The antioxidant activity and cytotoxicity of CUR-Ls were assessed. Hyaluronic acid (HA)/poly(vinyl alcohol) (PVA) hydrogels were optimized with a central composite design; then, poly(N-vinylpyrrolidone-co-itaconic acid) (PNVP-ITA) was synthesized to enrich the properties of the hydrogels. The drug release kinetics of the CUR-L@HA/PVA/PNVP-ITA hydrogels were studied. Skin recovery was investigated in vivo on rat dorsal skin. The optimized CUR-Ls were constructed from 2.7% Tween^® 20, 0.04% oleic acid, and 8.1% CUR, yielding nano-CUR-L with a narrow size distribution, negative surface charge, and CUR content of 19.92 ± 0.54 µg/mg. CUR-Ls improved the antioxidant effects of CUR. The optimized hydrogel contained 5% HA and 10% PVA. PNVP-ITA improved the properties of the hydrogels via enhanced cross-linking. CUR-Ls exhibited a more rapid release than CUR, whereas the hydrogels enhanced CUR release via a diffusion-controlled mechanism. CUR-L@HA/PVA/PNVP-ITA hydrogels improved the skin recovery rate compared to the commercial patch after 5 days. Therefore, the optimized CUR-L@HA/PVA/PNVP-ITA hydrogels facilitated skin recovery and could be a promising nanocomposite for wound dressings.

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用于伤口愈合的计算设计和优化的姜黄素脂质体嵌入式双功能交联水凝胶。

本研究介绍了一种在伤口愈合中有效输送姜黄素（CUR）的双功能交联纳米复合水凝胶。采用 Box-Behnken 设计优化了 CUR 负载脂质体（CUR-Ls）的粒度、粒度分布、zeta 电位和 CUR 浓度。评估了 CUR-Ls 的抗氧化活性和细胞毒性。采用中心复合设计对透明质酸（HA）/聚乙烯醇（PVA）水凝胶进行了优化，然后合成了聚（N-乙烯基吡咯烷酮-共二十二酸）（PNVP-ITA）以丰富水凝胶的性能。研究了 CUR-L@HA/PVA/PNVP-ITA 水凝胶的药物释放动力学。在大鼠背侧皮肤上进行了体内皮肤恢复研究。优化的 CUR-L 由 2.7% 的吐温® 20、0.04% 的油酸和 8.1% 的 CUR 构建而成，生成的纳米 CUR-L 具有窄尺寸分布、负表面电荷和 19.92 ± 0.54 µg/mg 的 CUR 含量。CUR-Ls 提高了 CUR 的抗氧化效果。优化的水凝胶含有 5% 的 HA 和 10% 的 PVA。PNVP-ITA 通过增强交联改善了水凝胶的性能。与 CUR 相比，CUR-Ls 的释放速度更快，而水凝胶则通过扩散控制机制增强了 CUR 的释放。与商业贴片相比，CUR-L@HA/PVA/PNVP-ITA 水凝胶提高了 5 天后的皮肤恢复率。因此，优化后的 CUR-L@HA/PVA/PNVP-ITA 水凝胶可促进皮肤恢复，是一种很有前景的伤口敷料纳米复合材料。

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来源期刊

Gels POLYMER SCIENCE-

CiteScore

4.70

自引率

19.60%

发文量

707

审稿时长

11 weeks

期刊介绍： The journal Gels (ISSN 2310-2861) is an international, open access journal on physical (supramolecular) and chemical gel-based materials. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the maximum length of the papers, and full experimental details must be provided so that the results can be reproduced. Short communications, full research papers and review papers are accepted formats for the preparation of the manuscripts. Gels aims to serve as a reference journal with a focus on gel materials for researchers working in both academia and industry. Therefore, papers demonstrating practical applications of these materials are particularly welcome. Occasionally, invited contributions (i.e., original research and review articles) on emerging issues and high-tech applications of gels are published as special issues.