Gels最新文献

Against the backdrop of promoting green buildings and a circular economy, the development of efficient, sustainable, and low-carbon cementitious materials is of great significance for reducing resource consumption and carbon emissions. In this study, plant ash (PA) was used as a partial cement replacement, and a series of alkali-activated composite cementitious materials (APAG) were prepared by regulating the dosages of PA and alkali activator (AA). The evolution of their workability, hydration behavior, and mechanical properties was systematically investigated. The results show that the incorporation of PA effectively delayed the setting process of the system; compared with P0, the initial and final setting times of P20 increased by approximately 302% and 100%, respectively, thereby mitigating the excessively rapid early-age reaction of the alkali-activated system while causing only a slight reduction in flowability. In contrast, the addition of AA shortened the setting time of APAG and led to a gradual decrease in fluidity. When the PA dosage was 20% and the AA dosage was 4%, APAG achieved a 28 d compressive strength of 57.8 MPa while maintaining good workability. Further analysis revealed a strong linear correlation between compressive strength and chemically bound water content under different PA and AA dosages, indicating that the reaction degree is a key factor governing macroscopic mechanical performance. Microstructural characterization confirmed that the incorporation of PA and AA significantly altered the reaction pathways and the morphology of hydration products, providing a reasonable microstructural explanation for the evolution of macroscopic properties. These findings provide valuable insights into the high-value utilization of biomass waste and the broader application of green cementitious materials.

Developing adsorbents that combine high capacity with structural robustness remains a critical challenge for dye wastewater treatment. In this study, we propose a "pollutant-induced gelation" strategy to address this limitation, using Fe(III)-activated palygorskite nanorod aggregates as a model system for the highly efficient sequestration of Congo red (CR). Unlike conventional modification methods that rely solely on surface functionalization, this approach leverages the adsorbed dye itself as a synergistic assembly promoter. The addition of CR significantly consolidates the Fe(III)-mediated aggregation of palygorskite nanorods, leading to the formation of an integrated three-dimensional porous network with distinct gel-like rheological behavior. This dye-induced gel network not only provides abundant confined spaces for pollutant entrapment but also enhances the structural integrity of the adsorbent, facilitating separation and potential reuse. Compared to pristine palygorskite, the Fe(III)-activated material exhibited a 95.4-277% increase in adsorption capacity across a pH range of 4-10. The adsorption process followed pseudo-second-order kinetics and the Temkin isotherm model, and was thermodynamically spontaneous and exothermic. Mechanistic studies revealed a synergistic interplay: Fe(III) served as primary cross-linking nodes to construct the network framework, while CR molecules acted as inducers to reinforce the gel architecture, enabling strong physical immobilization of dye aggregates. This work provides a new paradigm for designing intelligent, gel-based adsorbents from natural nanoclays, transforming a pollutant into a structural promoter.

Water scarcity, rapid soil moisture loss, and high evaporative demand severely limit vegetable production in arid regions such as Qatar. Sustainable soil amendments that enhance water retention and stabilize plant water status are therefore critical for improving productivity. This study evaluated a biodegradable hydrogel synthesized from date-palm leaf cellulose using a sodium alginate crosslinking method and assessed its effects on soil hydro-physical properties and tomato (Solanum lycopersicum L.) performance under arid conditions. A pot experiment was conducted under semi-controlled conditions using a single-factor randomized complete design with three hydrogel rates (0, 1, and 2% w/w) and three replications, with one plant per pot. All treatments received the same seasonal irrigation depth, scheduled when soil moisture declined to approximately 60-65% of field capacity. The hydrogel exhibited rapid hydration behavior, reaching equilibrium within 30-60 min with a swelling ratio of 5.659 g g^-1, corresponding to a water uptake of 465.9%, and SEM analysis revealed a porous internal structure favorable for water retention. At 1 and 2% application rates, hydrogel significantly reduced bulk density, increased total porosity and field capacity, and maintained higher soil moisture across irrigation cycles. Tomato plants grown in hydrogel-amended pots showed substantial gains in fresh biomass and root length, together with higher chlorophyll content, leaf nitrogen concentration, and relative water content. Water use efficiency improved significantly at 1% hydrogel, whereas the 2% rate showed a positive but non-significant trend. Overall, the results demonstrate that hydrogels derived from date-palm waste can enhance soil water retention, plant physiological status, and tomato productivity, offering a locally relevant strategy to improve agricultural resilience in arid environments.

Autologous adipose tissue (AT) grafting is often compromised by insufficient early vascularization, leading to ischemia, fibrosis, and inconsistent long-term volume retention. Incorporating platelet-rich plasma (PRP) into AT bioinks offers a clinically accessible means to enhance vascular recruitment, but the in vivo impact of PRP dosage remains unclear. Here, we investigated how PRP concentration, uniformly integrated into a previously reported clinically relevant AT bioink, regulates vascular infiltration, tissue remodeling, and overall graft survival. High-dose PRP markedly improved graft performance, including an 8-fold increase in highly perfused regions, a 3.8-fold enhancement in adipocyte survival, a 1.67-fold reduction in fibrosis, and a 2.51-fold increase in collagen III deposition compared with PRP-free AT grafts. Histological analysis further demonstrated that PRP mitigates the adverse effects of poor perfusion, reducing regional disparities in survival and extracellular matrix (ECM) remodeling. High-dose PRP also maximized graft retention, preserving 103% of graft mass relative to 50.6% in native AT. Together, these results establish a clear in vivo dose-response relationship for PRP-enhanced AT grafts and highlight platelet concentration as a key design parameter for soft-tissue reconstruction. This work provides a translational framework for optimizing PRP-functionalized bioinks to improve clinical outcomes in reconstructive surgery.

Alginate-based hydrogels, derived from brown seaweed, represent biocompatible and biodegradable materials whose properties are systematically controlled through molecular structure (M/G composition), crosslinking strategy, and compositional modification. This review synthesizes recent advances in alginate hydrogel design, encompassing fundamental structural properties, three primary crosslinking approaches-ionic coordination with divalent cations (Ca²⁺, Ba²⁺, Sr²⁺), covalent chemical linkages, and hybrid multi-crosslinking systems-and strategic modification strategies including chemical derivatization, polymer blending, and nanoparticle incorporation. These modifications address inherent limitations of native alginate, namely insufficient mechanical strength and biological inertness, thereby expanding applicability. The review examines applications across biomedical domains (drug delivery, tissue engineering, wound healing), environmental remediation, food industry systems, and emerging technologies including flexible electronics and soft robotics. Advanced fabrication techniques-3D/4D printing, microfluidics, and electrospinning-enable improved architectural control. Current evidence from preclinical and clinical studies demonstrates feasibility in specific applications, while important challenges persist, including predictable degradation kinetics, mechanical property optimization, standardization of characterization protocols, regulatory compliance, and manufacturing scalability. This review aims to provide a systematic assessment of alginate-based hydrogel development and identify areas requiring further investigation to advance clinical translation.

Post-cholecystectomy non-alcoholic fatty liver disease (NAFLD), now encompassed within metabolic dysfunction-associated steatotic liver disease (MASLD), is increasingly linked to persistent disruption of bile acid kinetics and gut-liver axis signaling after gallbladder removal. Continuous bile delivery to the intestine reshapes the bile acid pool, perturbs FXR-FGF19/TGR5 pathways, remodels gut microbiota, and compromises epithelial barrier integrity, collectively promoting portal endotoxemia, chronic hepatic inflammation, and fibrogenic remodeling. Hydrogel-based biomaterials offer a mechanistically aligned therapeutic platform for this setting because they enable localized, sustained, and stimuli-responsive interventions at intestinal or hepatic sites. Functional hydrogels can sequester excess bile acids, protect and deliver probiotics/prebiotics/postbiotics, reinforce mucosal barrier function, and provide controlled release of anti-inflammatory or antifibrotic agents with reduced systemic exposure. In this review, we map emerging hydrogel strategies relevant to post-cholecystectomy NAFLD across four pathogenic nodes, bile acid dysregulation, dysbiosis, inflammation, and fibrosis, and highlight design principles (polymer chemistry, charge/hydrophobicity balance, mucoadhesion, and pH/redox/enzyme responsiveness) that enable targeted modulation of the gut-liver axis. Finally, we identify key translational gaps, including the lack of post-cholecystectomy-specific experimental models and standardized outcome measures integrating bile acid profiling, microbiome readouts, and hepatic histology. Hydrogel technologies represent a promising route toward localized and multimodal therapy in metabolic liver disease, warranting focused preclinical validation and clinical development.

A novel co-encapsulation platform based on curcumin-loaded liposomes (Cur-Lip) incorporated into thermosensitive hydrogels (TSH) was developed to address the physicochemical and biological limitations of topical curcumin (Cur) delivery. Response Surface Methodology (RSM) was used to optimize Pluronic^® F-127, glycerol, and alginate concentrations with respect to gelation time and viscosity. The optimized formulation (22% Pluronic^® F-127, 5% glycerol, and 0.5% alginate) exhibited rapid time sol-gel transition (~86 s), suitable viscosity (~377 mPa·s), excellent model fitting (R² = 0.99) and prediction accuracy. Three formulations (TSH, Cur-TSH, and Cur-Lip-TSH) were subsequently prepared and displayed appropriate thermoresponsive behavior. The Cur-Lip system showed high encapsulation efficiency (~78%). Upon incorporation into the TSH, Cur-Lip-TSH displayed increased viscosity and mechanical strength at physiological temperature. In vitro studies confirmed its cytocompatibility toward human keratinocytes, significant antibacterial activity against Staphylococcus aureus, Staphylococcus epidermidis, and Pseudomonas aeruginosa, and no irritation potential as assessed by the Hen's Egg Test on the Chorioallantoic Membrane assay (HET-CAM). Overall, Cur-Lip-TSH represents a safe and robust thermosensitive platform that provides a foundation for future studies on controlled curcumin release and topical performance.

CaCO₃ and NaHCO₃, respectively serving as chemical leavening agents, can promote the expansion of protein or starch extrudates, thereby forming a porous structure. However, the characteristics of this porous structure under the combined regulation of CaCO₃ and NaHCO₃ remained unclear. The results indicated that increasing the proportion of NaHCO₃ promoted the expansion of the extruded protein-starch gel network, with its expansion ratio significantly increasing from 2.29 to 3.17 (p < 0.05). This expansion resulted in larger pores, which corroborated the observed significant increase in water holding capacity (WHC). Conversely, an increase in the proportion of CaCO₃ led to a denser porous structure accompanied by a reduction in WHC. Meanwhile, the extrudate with a CaCO₃/NaHCO₃ ratio of 0:2 exhibited the lowest hardness, measuring 8.87 N. As the proportion of NaHCO₃ increased, the pH shifted toward the alkaline range. This increase in pH enhanced the flexibility of the protein structure, leading to a significant rise in the proportion of disordered structures in the protein secondary structure, such as random coil and β-sheet, which facilitated the formation of an elastic gel network. In conclusion, both CaCO₃ and NaHCO₃ significantly modulated the porous structure of the protein-starch gel network formed during extrusion. This provides a new perspective for investigating the relationship between the protein-starch gel network and the quality characteristics of extruded products.

High salinity and hardness in flowback fluids from tight reservoirs severely degrade the performance of conventional fracturing fluids, leading to formation damage and imposing major constraints on water recycling. An innovative in situ molecular interface regulation strategy that bypasses the need for costly pretreatment was proposed. A novel zwitterionic polymer was synthesized by grafting trimethylamine N-oxide (TMAO) onto hydrolyzed polyacrylamide. This hydrolyzed polyacrylamide grafted with trimethylamine N-oxide polymer (HPAMT) leverages zwitterionic TMAO groups to form a robust hydration layer approximately 0.25 nm thick on the polymer chains. Each TMAO group can immobilize up to 22.2 water molecules, effectively shielding the polymer from the detrimental effects of ions like Ca²⁺ and Na⁺, thereby preventing chain curling and preserving cross-linking sites. Experimental results demonstrate that HPAMT fracturing fluid prepared with untreated flowback fluids retains over 70% of its initial viscosity. The HPAMT fracturing fluid exhibits superior thermal and shear stability, maintaining more than 90% viscosity after exposure to 90 °C and the shear rate of 170 s^-1 for 60 min. Furthermore, HPAMT provides excellent proppant suspension, exceeding 60 min of static settling time. The broken gel viscosity remains below 5 mPa·s, enabling the direct reuse of flowback water. This technology overcomes the critical compatibility issue between traditional polymers and challenging brine chemistry, significantly reducing freshwater consumption and operational costs, thus presenting a viable and innovative solution for enhancing the environmental sustainability of unconventional resource development.

With the rapid development of aerospace technology towards hypersonic vehicles, the synergistic demand for lightweighting and high-efficiency thermal insulation performance of ablation-resistant thermal insulation materials is becoming increasingly urgent. In this study, nanoporous phenolic resin was used as the matrix to prepare quartz fiber-reinforced phenolic aerogel composites (QF/PF), mullite fiber-reinforced phenolic aerogel composites (MF/PF), and carbon fiber-reinforced phenolic aerogel composites (CF/PF), and the influence mechanisms of different reinforcing fibers on the properties of the composites were systematically investigated. QF/PF exhibits optimal thermal insulation performance with a thermal conductivity of 0.1 W/(m·K) at 20-200 °C, followed by MF/PF with a thermal conductivity of 0.11 W/(m·K). Relatively weak thermal insulation performance is demonstrated in CF/PF, whose thermal conductivity reaches 0.14 W/(m·K). However, in terms of mechanical properties, CF/PF is outstanding, with a tensile strength of 54.62 MPa and a bending strength of 29.69 MPa. In addition, the most excellent ablation resistance is displayed in CF/PF, with a linear ablation rate of 0.13 mm/s and a mass ablation rate of 0.0435 g/s, which are significantly lower than QF/PF and MF/PF. This study provides an important basis for the selection of reinforcing fibers in different application scenarios. QF/PF or MF/PF is preferred for high thermal insulation requirements. CF/PF is favored for high load-bearing requirements or extreme ablative environments.