Development and Investigation of a Nanoemulgel Formulated from Tunisian Opuntia ficus-indica L. Seed Oil for Enhanced Wound Healing Activity.

IF 5 3区化学 Q1 POLYMER SCIENCE Gels Pub Date : 2024-09-09 DOI:10.3390/gels10090582

Badr Bahloul, Enis Ben Bnina, Dorra Dridi, Aya Bouhamed, Luis Castillo Henríquez, Guido Flamini, José Roberto Vega-Baudrit

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Abstract

The aim of this study is to develop a nanoemulgel encapsulating a Tunisian Prickly Pear (Opuntia ficus-indica L.) seed oil (PPSO) to assess, for the first time, the in vivo efficacy of this nanoformulation on wound healing. Phytocompounds of this oil have been reported in the literature as having powerful pharmacological activities. However, it remains poorly exploited due to low bioavailability. A nanoemulsion (NE) was designed by determining the required hydrophilic-lipophilic balance (HLB) and subsequently characterized. The mean droplet size was measured at 56.46 ± 1.12 nm, with a polydispersity index (PDI) of 0.23 ± 0.01 using dynamic light scattering. The zeta potential was -31.4 ± 1.4 mV, and the morphology was confirmed and assessed using transmission electron microscopy (TEM). These characteristics align with the typical properties of nanoemulsions. The gelification process resulted in the formation of a nanoemulgel from the optimum nanoemulsion. The high wound healing efficiency of the nanoemulgel was confirmed compared to that of a medicinally marketed cream. The outcomes of this research contribute valuable insights, for the first time, into the potential therapeutic applications of PPSO and its innovative pharmaceutical formulation for wound healing.

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开发和研究用突尼斯鸦片籽油配制的纳米凝胶，以增强伤口愈合活性。

本研究旨在开发一种包裹突尼斯刺梨（Opuntia ficus-indica L.）种子油（PPSO）的纳米凝胶，以首次评估这种纳米制剂对伤口愈合的体内疗效。据文献报道，这种油的植物化合物具有强大的药理活性。然而，由于生物利用率低，它的利用率仍然很低。通过确定所需的亲水-亲油平衡（HLB），我们设计了一种纳米乳液（NE），随后对其进行了表征。使用动态光散射法测得平均液滴大小为 56.46 ± 1.12 nm，多分散指数（PDI）为 0.23 ± 0.01。zeta 电位为 -31.4 ± 1.4 mV，形态通过透射电子显微镜（TEM）进行了确认和评估。这些特征符合纳米乳液的典型特性。在凝胶化过程中，最佳纳米乳液形成了纳米凝胶。经证实，与市场上销售的药用乳膏相比，纳米乳胶具有很高的伤口愈合效率。这项研究成果首次对 PPSO 及其创新药物制剂在伤口愈合方面的潜在治疗应用提供了宝贵的见解。

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来源期刊

Gels POLYMER SCIENCE-

CiteScore

4.70

自引率

19.60%

发文量

707

审稿时长

11 weeks

期刊介绍： The journal Gels (ISSN 2310-2861) is an international, open access journal on physical (supramolecular) and chemical gel-based materials. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the maximum length of the papers, and full experimental details must be provided so that the results can be reproduced. Short communications, full research papers and review papers are accepted formats for the preparation of the manuscripts. Gels aims to serve as a reference journal with a focus on gel materials for researchers working in both academia and industry. Therefore, papers demonstrating practical applications of these materials are particularly welcome. Occasionally, invited contributions (i.e., original research and review articles) on emerging issues and high-tech applications of gels are published as special issues.