Enhanced osseointegration and antimicrobial properties of 3D-Printed porous titanium alloys with copper-strontium doped calcium silicate coatings.

IF 2.3 4区医学 Q3 ENGINEERING, BIOMEDICAL Journal of Biomaterials Applications Pub Date : 2024-09-26 DOI:10.1177/08853282241287916

Xin Qi Cheng, Wei Xu, Long Hui Shao, Hua Qiao Shen, Hong Wei Liu

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Abstract

The 3D printing of porous titanium scaffolds reduces the elastic modulus of titanium alloys and promotes osteogenic integration. However, due to the biological inertness of titanium alloy materials, the implant-bone tissue interface is weakly bonded. A calcium silicate (CS) coating doped with polymetallic ions can impart various biological properties to titanium alloy materials. In this study, CuO and SrO binary-doped CS coatings were prepared on the surface of 3D-printed porous titanium alloy scaffolds using atmospheric plasma spraying and characterized by SEM, EDS, and XRD. Both CuO and SrO were successfully incorporated into the CS coating. The in vivo osseointegration evaluation of the composite coating-modified 3D-printed porous titanium alloy scaffolds was conducted using a rabbit bone defect model, showing that the in vivo osseointegration of 2% CuO-10% SrO-CS-modified 3D-printed porous titanium alloy was improved. The in vitro antimicrobial properties of the 2% CuO-10% SrO-CS-modified 3D-printed porous titanium alloy were evaluated through bacterial platform coating, co-culture liquid absorbance detection, and crystal violet staining experiments, demonstrating that the composite coating exhibited good antimicrobial properties. In conclusion, the composite scaffold possesses both osteointegration-promoting and antimicrobial properties, indicating a broad potential for clinical applications.

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掺杂铜锶硅酸钙涂层的三维打印多孔钛合金的骨结合和抗菌性能得到增强

多孔钛支架的三维打印技术降低了钛合金的弹性模量，促进了成骨整合。然而，由于钛合金材料的生物惰性，植入物与骨组织界面的结合力较弱。掺杂多金属离子的硅酸钙（CS）涂层可赋予钛合金材料各种生物特性。本研究利用大气等离子喷涂技术在三维打印多孔钛合金支架表面制备了 CuO 和 SrO 二元掺杂 CS 涂层，并通过扫描电镜、EDS 和 XRD 对其进行了表征。CuO和SrO都成功地融入了CS涂层。利用兔子骨缺损模型对复合涂层改性的三维打印多孔钛合金支架进行了体内骨结合评估，结果表明 2% CuO-10% SrO-CS 改性的三维打印多孔钛合金的体内骨结合得到了改善。通过细菌平台涂层、共培养液吸光度检测和水晶紫染色实验评估了 2% CuO-10% SrO-CS 改性三维打印多孔钛合金的体外抗菌性能，结果表明复合涂层具有良好的抗菌性能。总之，该复合支架具有促进骨整合和抗菌的双重特性，具有广泛的临床应用潜力。

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来源期刊

Journal of Biomaterials Applications 工程技术-材料科学：生物材料

CiteScore

5.10

自引率

3.40%

发文量

144

审稿时长

1.5 months

期刊介绍： The Journal of Biomaterials Applications is a fully peer reviewed international journal that publishes original research and review articles that emphasize the development, manufacture and clinical applications of biomaterials. Peer-reviewed articles by biomedical specialists from around the world cover: New developments in biomaterials, R&D, properties and performance, evaluation and applications Applications in biomedical materials and devices - from sutures and wound dressings to biosensors and cardiovascular devices Current findings in biological compatibility/incompatibility of biomaterials The Journal of Biomaterials Applications publishes original articles that emphasize the development, manufacture and clinical applications of biomaterials. Biomaterials continue to be one of the most rapidly growing areas of research in plastics today and certainly one of the biggest technical challenges, since biomaterial performance is dependent on polymer compatibility with the aggressive biological environment. The Journal cuts across disciplines and focuses on medical research and topics that present the broadest view of practical applications of biomaterials in actual clinical use. The Journal of Biomaterial Applications is devoted to new and emerging biomaterials technologies, particularly focusing on the many applications which are under development at industrial biomedical and polymer research facilities, as well as the ongoing activities in academic, medical and applied clinical uses of devices.