Healing Potential of the Marine Polysaccharides Carrageenan and Ulvan on Second-Degree Burns.

IF 5 3区 医学 Q1 ENGINEERING, BIOMEDICAL Journal of Functional Biomaterials Pub Date : 2024-09-05 DOI:10.3390/jfb15090257
Dimitra Statha, Asimina Papaioannou, Stefanos Kikionis, Maria Kostaki, Ioannis Sfiniadakis, Andreas Vitsos, Jane Anastassopoulou, Efstathia Ioannou, Vassilios Roussis, Michail Christou Rallis
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Abstract

The treatment of second-degree burn wounds presents a significant clinical challenge, often characterized by prolonged healing times and risk of complications. In this study, the wound healing potential of bioactive marine sulfated polysaccharides ulvan and carrageenan formulated in gels at concentrations of 1.5%, 5.0%, and 10% w/w was evaluated. Hairless female SKH-hr2 mice (n = 7 per treatment) with burn-inflamed skin were treated with the polysaccharide-based gels, and the therapeutic efficacy was assessed using a comprehensive array of evaluation methods, including a histopathological analysis, clinical observation, photo-documentation, an image analysis, an evaluation of biophysical skin parameters, and FT-IR spectroscopy. Our findings indicate that the 10% w/w carrageenan gel exhibited significant enhancement in wound healing, particularly in the early stages of the healing process. This was evidenced by the restoration of the α-helix structure of collagen and the configuration of glycosaminoglycans, as demonstrated by FT-IR absorption bands of the skin both in vivo and ex vivo. Furthermore, the 5% w/w ulvan gel also demonstrated notable efficacy in promoting wound healing, particularly in the later stages of the healing process. These results suggest that carrageenan and ulvan gels hold promise for improving the efficiency of wound healing in second-degree burn wounds. Our study contributes to the understanding of the therapeutic potential of marine polysaccharides and provides insights into their mechanism of action in promoting wound healing.

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海洋多糖卡拉胶和乌尔凡对二度烧伤的愈合潜力
二度烧伤创面的治疗是一项重大的临床挑战,其特点通常是愈合时间长且有并发症风险。本研究评估了生物活性海洋硫酸化多糖 ulvan 和卡拉胶配制成凝胶的伤口愈合潜力,浓度分别为 1.5%、5.0% 和 10% w/w。用多糖凝胶治疗皮肤烧伤发炎的无毛雌性 SKH-hr2 小鼠(每次治疗 7 只),并采用一系列综合评估方法评估疗效,包括组织病理学分析、临床观察、照片记录、图像分析、皮肤生物物理参数评估和傅立叶变换红外光谱法。我们的研究结果表明,10% w/w 角叉菜胶凝胶能显著促进伤口愈合,尤其是在愈合过程的早期阶段。体内和体外皮肤的傅立叶变换红外吸收波段都证明了这一点,即胶原蛋白的 α-helix 结构和糖胺聚糖的构型得到了恢复。此外,5% w/w ulvan 凝胶在促进伤口愈合方面也有显著功效,尤其是在愈合过程的后期阶段。这些结果表明,卡拉胶和乌尔凡凝胶有望提高二度烧伤伤口的愈合效率。我们的研究有助于人们了解海洋多糖的治疗潜力,并深入探讨其促进伤口愈合的作用机制。
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来源期刊
Journal of Functional Biomaterials
Journal of Functional Biomaterials Engineering-Biomedical Engineering
CiteScore
4.60
自引率
4.20%
发文量
226
审稿时长
11 weeks
期刊介绍: Journal of Functional Biomaterials (JFB, ISSN 2079-4983) is an international and interdisciplinary scientific journal that publishes regular research papers (articles), reviews and short communications about applications of materials for biomedical use. JFB covers subjects from chemistry, pharmacy, biology, physics over to engineering. The journal focuses on the preparation, performance and use of functional biomaterials in biomedical devices and their behaviour in physiological environments. Our aim is to encourage scientists to publish their results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Several topical special issues will be published. Scope: adhesion, adsorption, biocompatibility, biohybrid materials, bio-inert materials, biomaterials, biomedical devices, biomimetic materials, bone repair, cardiovascular devices, ceramics, composite materials, dental implants, dental materials, drug delivery systems, functional biopolymers, glasses, hyper branched polymers, molecularly imprinted polymers (MIPs), nanomedicine, nanoparticles, nanotechnology, natural materials, self-assembly smart materials, stimuli responsive materials, surface modification, tissue devices, tissue engineering, tissue-derived materials, urological devices.
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