Investigation of Mechanical and Corrosion Properties of New Mg-Zn-Ga Amorphous Alloys for Biomedical Applications.

IF 5 3区 医学 Q1 ENGINEERING, BIOMEDICAL Journal of Functional Biomaterials Pub Date : 2024-09-20 DOI:10.3390/jfb15090275
Viacheslav E Bazhenov, Mikhail V Gorobinskiy, Andrey I Bazlov, Vasiliy A Bautin, Andrey V Koltygin, Alexander A Komissarov, Denis V Ten, Anna V Li, Alexey Yu Drobyshev, Yoongu Kang, In-Ho Jung, Kwang Seon Shin
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Abstract

Magnesium alloys are considered as promising materials for use as biodegradable implants due to their biocompatibility and similarity to human bone properties. However, their high corrosion rate in bodily fluids limits their use. To address this issue, amorphization can be used to inhibit microgalvanic corrosion and increase corrosion resistance. The Mg-Zn-Ga metallic glass system was investigated in this study, which shows potential for improving the corrosion resistance of magnesium alloys for biodegradable implants. According to clinical tests, it has been demonstrated that Ga ions are effective in the regeneration of bone tissue. The microstructure, phase composition, and phase transition temperatures of sixteen Mg-Zn-Ga alloys were analyzed. In addition, a liquidus projection of the Mg-Zn-Ga system was constructed and validated through the thermodynamic calculations based on the CALPHAD-type database. Furthermore, amorphous ribbons were prepared by rapid solidification of the melt for prospective alloys. XRD and DSC analysis indicate that the alloys with the most potential possess an amorphous structure. The ribbons exhibit an ultimate tensile strength of up to 524 MPa and a low corrosion rate of 0.1-0.3 mm/year in Hanks' solution. Therefore, it appears that Mg-Zn-Ga metallic glass alloys could be suitable for biodegradable applications.

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用于生物医学应用的新型镁锌镓非晶合金的机械和腐蚀特性研究
镁合金因其生物相容性和与人体骨骼相似的特性,被认为是有希望用作生物可降解植入体的材料。然而,镁合金在体液中的高腐蚀率限制了其使用。为了解决这个问题,可以利用非晶化来抑制微电化学腐蚀并提高耐腐蚀性。本研究对 Mg-Zn-Ga 金属玻璃系统进行了研究,结果表明该系统具有提高可生物降解植入体镁合金耐腐蚀性的潜力。临床试验证明,镓离子能有效促进骨组织再生。本文分析了 16 种 Mg-Zn-Ga 合金的微观结构、相组成和相变温度。此外,通过基于 CALPHAD 型数据库的热力学计算,构建并验证了 Mg-Zn-Ga 系统的液相投影。此外,还通过熔体的快速凝固制备了未来合金的无定形带。XRD 和 DSC 分析表明,最具潜力的合金具有非晶态结构。这些带材的极限拉伸强度高达 524 兆帕,在汉克斯溶液中的腐蚀速率低至 0.1-0.3 毫米/年。因此,Mg-Zn-Ga 金属玻璃合金似乎适合生物降解应用。
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来源期刊
Journal of Functional Biomaterials
Journal of Functional Biomaterials Engineering-Biomedical Engineering
CiteScore
4.60
自引率
4.20%
发文量
226
审稿时长
11 weeks
期刊介绍: Journal of Functional Biomaterials (JFB, ISSN 2079-4983) is an international and interdisciplinary scientific journal that publishes regular research papers (articles), reviews and short communications about applications of materials for biomedical use. JFB covers subjects from chemistry, pharmacy, biology, physics over to engineering. The journal focuses on the preparation, performance and use of functional biomaterials in biomedical devices and their behaviour in physiological environments. Our aim is to encourage scientists to publish their results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Several topical special issues will be published. Scope: adhesion, adsorption, biocompatibility, biohybrid materials, bio-inert materials, biomaterials, biomedical devices, biomimetic materials, bone repair, cardiovascular devices, ceramics, composite materials, dental implants, dental materials, drug delivery systems, functional biopolymers, glasses, hyper branched polymers, molecularly imprinted polymers (MIPs), nanomedicine, nanoparticles, nanotechnology, natural materials, self-assembly smart materials, stimuli responsive materials, surface modification, tissue devices, tissue engineering, tissue-derived materials, urological devices.
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