Relationships between Serum Lipid, Uric Acid Levels and Mild Cognitive Impairment in Parkinson's Disease and Multiple System Atrophy.

IF 2.5 4区医学 Q3 NEUROSCIENCES Journal of integrative neuroscience Pub Date : 2024-09-18 DOI:10.31083/j.jin2309168

Xiaoqiao Ren, Pan Wang, Hao Wu, Shuai Liu, Jinhong Zhang, Xiyu Li, Yong Ji, Zhihong Shi

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Abstract

Background: Mild cognitive impairment is one of the non-motor symptoms in Parkinson's disease (PD) and multiple system atrophy (MSA). Few studies have previously been conducted on the correlation between serum uric acid (SUA) and lipid levels and mild cognitive impairment in PD and MSA.

Methods: Participants included 149 patients with PD and 99 patients with MSA. The Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) were used to evaluate cognitive function. Evaluations were conducted on SUA and lipid levels, which included triglyceride, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and total cholesterol (TC).

Results: Patients with PD and MSA diagnosed with mild cognitive impairment demonstrated multiple cognitive domain impairment when compared with patients with normal cognition. Attentional impairment was more pronounced in patients with MSA when compared with PD (p = 0.001). In PD, the risk of mild cognitive impairment was lower in the highest quartiles and secondary quartile of SUA than in the lowest quartiles (odds ratio [OR] = 0.281, 95% confidence intervals [CI]: 0.097-0.810, p = 0.019; and OR = 0.317, 95% CI: 0.110-0.911, p = 0.033). In MSA, the risk of mild cognitive impairment was lower in the third and highest quartile of SUA than in the lowest quartile (OR = 0.233, 95% CI: 0.063-0.868, p = 0.030; and OR = 0.218, 95% CI: 0.058-0.816, p = 0.024). In patients with PD, the MoCA scores were negatively correlated with TC levels (r = -0.226, p = 0.006) and positively correlated with SUA levels (r = 0.206, p = 0.012). In MSA, the MoCA scores were positively correlated with SUA levels (r = 0.353, p = 0.001).

Conclusions: Lower SUA levels and higher TC levels are a possible risk factor for the risk and severity of mild cognitive impairment in PD. Lower SUA levels are a possible risk factor for the risk and severity of mild cognitive impairment in MSA.

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帕金森病和多系统萎缩患者血清脂质、尿酸水平与轻度认知功能障碍之间的关系

背景：轻度认知障碍是帕金森病（PD）和多系统萎缩（MSA）的非运动症状之一。关于帕金森病和多系统萎缩症患者血清尿酸（SUA）和血脂水平与轻度认知障碍之间的相关性，此前鲜有研究：参与者包括 149 名 PD 患者和 99 名 MSA 患者。评估认知功能时使用了迷你精神状态检查（MMSE）和蒙特利尔认知评估（MoCA）。对 SUA 和血脂水平进行评估，包括甘油三酯、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）和总胆固醇（TC）：与认知能力正常的患者相比，被诊断为轻度认知障碍的帕金森病和澳门金沙在线娱乐平台障碍患者表现出多个认知领域的障碍。与帕金森病患者相比，MSA 患者的注意力损伤更为明显（p = 0.001）。在帕金森病患者中，SUA最高四分位数和次高四分位数的轻度认知障碍风险低于最低四分位数（几率比[OR] = 0.281，95%置信区间[CI]：0.097-0.810）：0.097-0.810, p = 0.019; OR = 0.317, 95% CI: 0.110-0.911, p = 0.033）。在 MSA 中，SUA 的第三和最高四分位数的轻度认知障碍风险低于最低四分位数（OR = 0.233，95% CI：0.063-0.868，p = 0.030；OR = 0.218，95% CI：0.058-0.816，p = 0.024）。在PD患者中，MoCA评分与TC水平呈负相关（r = -0.226，p = 0.006），与SUA水平呈正相关（r = 0.206，p = 0.012）。在 MSA 中，MoCA 分数与 SUA 水平呈正相关（r = 0.353，p = 0.001）：结论：较低的 SUA 水平和较高的 TC 水平可能是导致帕金森病轻度认知障碍风险和严重程度的危险因素。较低的 SUA 水平可能是导致 MSA 轻度认知障碍的风险和严重程度的风险因素。

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来源期刊

Journal of integrative neuroscience 医学-神经科学

CiteScore

2.80

自引率

5.60%

发文量

173

审稿时长

2 months

期刊介绍： JIN is an international peer-reviewed, open access journal. JIN publishes leading-edge research at the interface of theoretical and experimental neuroscience, focusing across hierarchical levels of brain organization to better understand how diverse functions are integrated. We encourage submissions from scientists of all specialties that relate to brain functioning.