Long-term neurodevelopmental outcomes at three years in preterm infants born before 29 Weeks gestation following Preterm Premature Rupture of Membranes (PPROM).

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY Journal of Perinatology Pub Date : 2024-09-30 DOI:10.1038/s41372-024-02134-8

Harkirat Bhullar, Amelie Stritzke, Sue Makarchuk, Selphee Tang, Abhay Lodha

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Abstract

Objective: To determine the association between preterm premature rupture of membranes (PPROM) and neurodevelopmental impairment (NDI) at 3 years corrected age (CA) in infants born before 29 weeks of gestational age (GA).

Design/methods: Infants born before 29 weeks GA between 2005 and 2017 were included. The primary outcome was a composite of death or NDI (full-scale intelligence quotient<85, cerebral palsy, vision or hearing impairment) at 3 years of CA. Infants were stratified by maternal PPROM status. Associations were explored using multivariate models.

Results: Of 1231 participants, 481 were in the PPROM group, and 750 were in the No PPROM group. After adjusting for factors, the odds ratio of death or NDI for PPROM vs. No PPROM was 1.22 (95% Confidence Interval 0.93-1.59).

Conclusion: Our study suggests that PPROM was not associated with an increased risk of a composite outcome of death or NDI at 3 years CA.

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妊娠 29 周前出生的早产儿在胎膜早破（PPROM）后 3 年的长期神经发育结果。

目的确定胎龄（GA）29周前出生的早产胎膜早破（PPROM）与3岁矫正年龄（CA）时神经发育障碍（NDI）之间的关联：纳入2005年至2017年间胎龄29周前出生的婴儿。主要结果是死亡或NDI（全量表智商）的综合结果：在1231名参与者中，481人属于PPROM组，750人属于无PPROM组。在对各种因素进行调整后，PPROM 与无 PPROM 死亡或 NDI 的几率比为 1.22（95% 置信区间为 0.93-1.59）：我们的研究表明，PPROM 与 3 年 CA 时死亡或 NDI 综合结果的风险增加无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.