Rodrigo Cunha Oliveira, Darren Martin, Juliana Sacramento Mota de Souza, Luiz Carlos Júnior Alcântara, Monick Lindenmeyer Guimarães, Carlos Brites, Joana Paixão Monteiro-Cunha
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引用次数: 0
Abstract
Background: The human immunodeficiency virus 1 (HIV-1) infections in Brazil are predominantly caused by two subtypes, B and C.
Objectives: Here we present the characterisation of a novel HIV-1 recombinant form, indicating a new Brazilian CRF_BC, named CRF146_BC.
Methods: RDP, JphMM and Simplot recombination tools were used to evaluate the mosaic pattern.
Findings: In this work, we identified three HIV-1 nucleotide sequences previously classified as unique recombinant forms (URFs), plus one new partial genome sharing the same BC recombination pattern. The mosaic genome is almost entirely represented by the subtype C sequence, with a small subtype B recombination region in the pol gene, at the Integrase level. The phylogenetic analyses strongly indicate a common origin between the strains, which were isolated in Rio Grande do Sul, Rio de Janeiro and Bahia states.
Main conclusions: Thus, the new HIV-1 CRF146_BC is circulating in three different Brazilian regions: South, Southeast and Northeast.
背景：巴西的人类免疫缺陷病毒 1（HIV-1）感染主要由 B 和 C 两种亚型引起：在此，我们介绍了一种新型 HIV-1 重组形式的特征，它表明了一种新的巴西 CRF_BC，名为 CRF146_BC：方法：使用 RDP、JphMM 和 Simplot 重组工具评估马赛克模式：在这项工作中，我们发现了三个以前被归类为独特重组形式（URF）的 HIV-1 核苷酸序列，以及一个具有相同 BC 重组模式的新的部分基因组。在整合酶水平上，马赛克基因组几乎完全由 C 亚型序列代表，在 pol 基因中有一个小的 B 亚型重组区。系统发生学分析强烈表明，这些分离自南里约格朗德州、里约热内卢州和巴伊亚州的菌株具有共同的起源：因此，新的 HIV-1 CRF146_BC 在巴西三个不同地区流行：主要结论：因此，新的 HIV-1 CRF146_BC 在巴西三个不同地区流行：南部、东南部和东北部。
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