Application of Mozart's Sonata for Two Pianos in D Major in Children with Epilepsy and Effect of Acoustic Quality on Epileptic Discharges.

IF 1.3 4区医学 Q3 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY Noise & Health Pub Date : 2024-07-01 Epub Date: 2024-09-30 DOI:10.4103/nah.nah_75_24

Liping Zheng, Lin Lin, Qinghuang Zeng

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Abstract

Background: Mozart's Sonata for Two Pianos in D Major (K448) is a classic double piano work. This study investigated its effect on children with epilepsy (EP) and analyzed the changes in electroencephalography (EEG) among children on the basis of acoustic quality.

Methods: The clinical data of 150 children with EP in the Affiliated Hospital (Group) of Putian University from March 2020 to March 2023 were retrospectively analyzed. They were divided into group A (n = 73, antiepileptic drug therapy) and group B (n = 77, antiepileptic drug therapy + Mozart K448) in accordance with the treatment methods. The seizure frequency, frequency of epileptic discharges (EDs), and Quality of Life in Childhood Epilepsy Questionnaire-16 in both groups were compared before and after treatment. The changes in EEG before, during, and after music appreciation were observed. The effects of the acoustic characteristics (rhythm, root mean square value, roughness, and spectral flux) of Mozart K448 on EDs in children were explored.

Results: After treatment, group A had a higher seizure frequency (P < 0.001), a higher frequency of EDs (P < 0.05), and significantly lower scores of cognition and emotion than group B (P < 0.001), without significant difference in the scores of social function and physical function (P > 0.05). The frequency of EDs before music appreciation was significantly higher than that during music appreciation (P < 0.01). Spearman correlation analysis showed that the rhythm, spectral flux, and roughness in Mozart K488 were related to the decrease in EDs among children with EP (P < 0.001).

Conclusion: This study confirmed the application effect of Mozart K448 in children with EP. Mozart K448 can decrease the seizure frequency, reduce the ED occurrence, and improve the quality of life. The acoustic characteristics of K448 may be the reason for improving EP in children.

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莫扎特 D 大调双钢琴奏鸣曲在癫痫儿童中的应用及音质对癫痫放电的影响。

背景介绍莫扎特的《D大调双钢琴奏鸣曲》（K448）是一部经典的双钢琴作品。本研究探讨了该作品对癫痫患儿的影响，并根据音质分析了患儿脑电图（EEG）的变化：方法：回顾性分析莆田学院附属医院（集团）自2020年3月至2023年3月150名癫痫患儿的临床资料。按照治疗方法分为A组（n=73，抗癫痫药物治疗）和B组（n=77，抗癫痫药物治疗+莫扎特K448）。比较两组患者治疗前后的发作频率、癫痫放电频率（EDs）和儿童癫痫生活质量问卷-16。观察了音乐欣赏前、欣赏过程中和欣赏后脑电图的变化。探讨了莫扎特 K448 的声学特征（节奏、均方根值、粗糙度和频谱通量）对儿童 ED 的影响：结果：治疗后，A 组的癫痫发作频率高于 B 组（P < 0.001），ED 频率高于 B 组（P < 0.05），认知和情感评分显著低于 B 组（P < 0.001），社会功能和身体功能评分无显著差异（P > 0.05）。音乐欣赏前出现 ED 的频率明显高于音乐欣赏时（P < 0.01）。斯皮尔曼相关分析表明，莫扎特K488的节奏、频谱通量和粗糙度与EP儿童ED的减少有关（P < 0.001）：本研究证实了莫扎特K448在EP患儿中的应用效果。结论：本研究证实了莫扎特K448在EP患儿中的应用效果。K448 的声学特性可能是改善儿童 EP 的原因。

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来源期刊

Noise & Health AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY-PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

CiteScore

2.10

自引率

14.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Noise and Health is the only International Journal devoted to research on all aspects of noise and its effects on human health. An inter-disciplinary journal for all professions concerned with auditory and non-auditory effects of occupational, environmental, and leisure noise. It aims to provide a forum for presentation of novel research material on a broad range of topics associated with noise pollution, its control and its detrimental effects on hearing and health. It will cover issues from basic experimental science through clinical evaluation and management, technical aspects of noise reduction systems and solutions to environmental issues relating to social and public health policy.