Ori Peleg, Rébaï Soret, Pom Charras, Vsevolod Peysakhovich, Anat Mirelman, Inbal Maidan, Daniel A Levy
{"title":"Getting oriented: Redefining attention deficits in Parkinson's disease.","authors":"Ori Peleg, Rébaï Soret, Pom Charras, Vsevolod Peysakhovich, Anat Mirelman, Inbal Maidan, Daniel A Levy","doi":"10.1037/neu0000973","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Parkinson's disease (PD) may affect not only motor functions, but also cognitive processes such as attention. While past research has examined PD impact on spatial attention, it has not addressed how the key functions of attentional orienting and alerting in PD are mediated by cueing format, an ecologically relevant parameter. We assessed how exogenous and endogenous orienting cue modes affect PD patients' visuospatial attention expressed as dorsal attention network orienting benefits, ventral attention network reorienting costs, and alerting abilities.</p><p><strong>Method: </strong>Ninety PD patients and 72 healthy comparison participants performed a spatial attention task in an engaging game format which required selection of a target location without prior cueing, or with temporal, valid spatial, or invalid spatial exogenous or endogenous cueing.</p><p><strong>Results: </strong>PD patients differed from healthy participants only in response time benefits in orienting under endogenous probabilistically predictive cue processing. They did not exhibit greater reorienting costs, differences in inhibition of return, or alerting deficits, irrespective of modes of cueing.</p><p><strong>Conclusion: </strong>These results suggest that fundamental orienting and alerting functions might be intact in PD, with challenges emerging only if additional cognitive processes, including those related to motor preparation, are required to utilize cue information. (PsycInfo Database Record (c) 2024 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":null,"pages":null},"PeriodicalIF":2.6000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuropsychology","FirstCategoryId":"102","ListUrlMain":"https://doi.org/10.1037/neu0000973","RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/26 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: Parkinson's disease (PD) may affect not only motor functions, but also cognitive processes such as attention. While past research has examined PD impact on spatial attention, it has not addressed how the key functions of attentional orienting and alerting in PD are mediated by cueing format, an ecologically relevant parameter. We assessed how exogenous and endogenous orienting cue modes affect PD patients' visuospatial attention expressed as dorsal attention network orienting benefits, ventral attention network reorienting costs, and alerting abilities.
Method: Ninety PD patients and 72 healthy comparison participants performed a spatial attention task in an engaging game format which required selection of a target location without prior cueing, or with temporal, valid spatial, or invalid spatial exogenous or endogenous cueing.
Results: PD patients differed from healthy participants only in response time benefits in orienting under endogenous probabilistically predictive cue processing. They did not exhibit greater reorienting costs, differences in inhibition of return, or alerting deficits, irrespective of modes of cueing.
Conclusion: These results suggest that fundamental orienting and alerting functions might be intact in PD, with challenges emerging only if additional cognitive processes, including those related to motor preparation, are required to utilize cue information. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
目的:帕金森病(PD)不仅会影响运动功能,还会影响注意力等认知过程。虽然过去的研究已经探讨了帕金森病对空间注意力的影响,但还没有涉及帕金森病中注意力定向和警觉的关键功能是如何通过提示形式这一生态相关参数来介导的。我们评估了外源性和内源性定向提示模式如何影响帕金森病患者的视觉空间注意,具体表现为背侧注意网络定向益处、腹侧注意网络重定向代价和警觉能力:90名帕金森氏症患者和72名健康对比参与者以引人入胜的游戏形式完成了一项空间注意力任务,该任务要求在没有事先提示的情况下选择目标位置,或在有时间、有效空间或无效空间外源性或内源性提示的情况下选择目标位置:与健康参与者相比,帕金森病患者仅在内源性概率预测线索处理下的定向反应时间优势方面与健康参与者不同。无论采用哪种线索模式,他们都没有表现出更大的重新定向成本、回返抑制差异或警觉缺陷:这些结果表明,帕金森病患者的基本定向和警觉功能可能完好无损,只有在需要额外的认知过程(包括与运动准备有关的认知过程)来利用线索信息时,才会出现挑战。(PsycInfo Database Record (c) 2024 APA, all rights reserved)。
期刊介绍:
Neuropsychology publishes original, empirical research; systematic reviews and meta-analyses; and theoretical articles on the relation between brain and human cognitive, emotional, and behavioral function.