Green Tea Kombucha Impacts Inflammation and Salivary Microbiota in Individuals with Excess Body Weight: A Randomized Controlled Trial.

IF 4.8 2区医学 Q1 NUTRITION & DIETETICS Nutrients Pub Date : 2024-09-20 DOI:10.3390/nu16183186

Gabriela Macedo Fraiz, Dandara Baia Bonifácio, Udielle Vermelho Lacerda, Rodrigo Rezende Cardoso, Viviana Corich, Alessio Giacomini, Hércia Stampini Duarte Martino, Sergio Esteban Echeverría, Frederico Augusto Ribeiro de Barros, Fermín I Milagro, Josefina Bressan

{"title":"Green Tea Kombucha Impacts Inflammation and Salivary Microbiota in Individuals with Excess Body Weight: A Randomized Controlled Trial.","authors":"Gabriela Macedo Fraiz, Dandara Baia Bonifácio, Udielle Vermelho Lacerda, Rodrigo Rezende Cardoso, Viviana Corich, Alessio Giacomini, Hércia Stampini Duarte Martino, Sergio Esteban Echeverría, Frederico Augusto Ribeiro de Barros, Fermín I Milagro, Josefina Bressan","doi":"10.3390/nu16183186","DOIUrl":null,"url":null,"abstract":"Background: Green tea kombucha (GTK) is a fermented beverage with promising health benefits, but few studies proved its impact on human health. Thus, we aimed to investigate the impact of GTK on weight loss, inflammation, and salivary microbiota in individuals with excess body weight.Methods: This is a randomized controlled clinical trial that lasted 10 weeks with two groups of individuals with excess body weight: control (CG; n = 29; caloric restriction) and kombucha (KG; n = 30; caloric restriction + 200 mL GTK). Body composition, anthropometry, saliva, and blood collection were performed in the beginning and end of the intervention. Plasma interleukins were determined by flow cytometry. Salivary microbiota was analyzed by 16S rRNA sequencing.Results: Both groups decreased weight, BMI, and body fat (p < 0.001) after the intervention, but there were no differences between groups. The KG reduced lipid accumulation product (LAP) (p = 0.029). Both groups decreased IL-1β and IL-8, but IL-6 increased in the CG (p = 0.023) compared to the kombucha group. Alpha and beta diversity of salivary microbiota increased in the KG. Moreover, the KG presented lower Bacillota/Bacteroidota ratio (p = 0.028), and BMI was positively associated with the Bacillota phylum.Conclusions: GTK did not enhance weight loss, but it decreased the LAP. GTK helped in the inflammatory profile and induced positive changes in oral microbiota composition.","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":null,"pages":null},"PeriodicalIF":4.8000,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11435194/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrients","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3390/nu16183186","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Green tea kombucha (GTK) is a fermented beverage with promising health benefits, but few studies proved its impact on human health. Thus, we aimed to investigate the impact of GTK on weight loss, inflammation, and salivary microbiota in individuals with excess body weight.

Methods: This is a randomized controlled clinical trial that lasted 10 weeks with two groups of individuals with excess body weight: control (CG; n = 29; caloric restriction) and kombucha (KG; n = 30; caloric restriction + 200 mL GTK). Body composition, anthropometry, saliva, and blood collection were performed in the beginning and end of the intervention. Plasma interleukins were determined by flow cytometry. Salivary microbiota was analyzed by 16S rRNA sequencing.

Results: Both groups decreased weight, BMI, and body fat (p < 0.001) after the intervention, but there were no differences between groups. The KG reduced lipid accumulation product (LAP) (p = 0.029). Both groups decreased IL-1β and IL-8, but IL-6 increased in the CG (p = 0.023) compared to the kombucha group. Alpha and beta diversity of salivary microbiota increased in the KG. Moreover, the KG presented lower Bacillota/Bacteroidota ratio (p = 0.028), and BMI was positively associated with the Bacillota phylum.

Conclusions: GTK did not enhance weight loss, but it decreased the LAP. GTK helped in the inflammatory profile and induced positive changes in oral microbiota composition.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

绿茶昆布茶影响体重超标者的炎症和唾液微生物群：随机对照试验

背景：绿茶昆布茶（GTK）是一种有益健康的发酵饮料，但很少有研究证明它对人体健康有影响。因此，我们旨在研究绿茶昆布茶对体重超重者的减肥、炎症和唾液微生物群的影响：这是一项为期 10 周的随机对照临床试验，对象是两组体重超标者：对照组（CG；n = 29；热量限制）和昆布茶组（KG；n = 30；热量限制 + 200 毫升 GTK）。在干预开始和结束时进行身体成分、人体测量、唾液和血液采集。血浆白细胞介素通过流式细胞术测定。唾液微生物群通过 16S rRNA 测序进行分析：结果：干预后，两组的体重、体重指数和体脂都有所下降（p < 0.001），但组间无差异。KG 降低了脂质累积产物（LAP）（p = 0.029）。两组都减少了 IL-1β 和 IL-8，但与昆布茶组相比，CG 组的 IL-6 增加了（p = 0.023）。KG组唾液微生物群的α和β多样性有所增加。此外，KG 组的芽孢杆菌/类杆菌比率较低（p = 0.028），而体重指数与芽孢杆菌门呈正相关：结论：GTK并不能减轻体重，但能降低LAP。结论：GTK 并未减轻体重，但却降低了 LAP。GTK 有助于改善炎症状况，并诱导口腔微生物群组成发生积极变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Nutrients NUTRITION & DIETETICS-

CiteScore

9.20

自引率

15.30%

发文量

4599

审稿时长

16.74 days

期刊介绍： Nutrients (ISSN 2072-6643) is an international, peer-reviewed open access advanced forum for studies related to Human Nutrition. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.