Abnormal T Cells Function Associated With Intraspinal Cold Abscess Caused by Macrolide-resistant Mycoplasma pneumoniae in a Patient With X-linked Agammaglobulinemia.

IF 2.9 4区 医学 Q3 IMMUNOLOGY Pediatric Infectious Disease Journal Pub Date : 2024-10-01 DOI:10.1097/INF.0000000000004569
Ying-Ying Jin, Jing Wu, Fei Ding, Hua Huang, Xue-Mei Xu, Qi-Min Chen, Min-Zhi Yin, Yu-Min Zhong, Yan-Liang Jin
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Abstract

Intraspinal cold abscesses caused by macrolide-resistant Mycoplasma pneumoniae in patients with X-linked agammaglobulinemia have not yet been described to our knowledge. Here we describe a patient with X-linked agammaglobulinemia who developed an intraspinal cold abscess caused by macrolide-resistant M. pneumoniae . Genetic analysis revealed a hemizygous c.1566 + 1G > C (IVS15 + 1G > C) mutation in BTK gene. The patient showed relatively naive T cells and a significant proliferative defect.

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X-连锁丙种球蛋白血症患者椎管内冷脓肿与耐大环内酯肺炎支原体引起的T细胞功能异常有关
据我们所知,X-连锁丙种球蛋白血症患者中由耐大环内酯类药物的肺炎支原体引起的椎管内冷脓肿尚未见报道。在这里,我们描述了一名 X 连锁丙种球蛋白血症患者因耐药大环内酯肺炎支原体引起的椎管内冷脓肿。基因分析显示,BTK 基因存在一个半杂合子 c.1566 + 1G > C(IVS15 + 1G > C)突变。患者表现出相对幼稚的 T 细胞和明显的增殖缺陷。
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来源期刊
CiteScore
6.30
自引率
2.80%
发文量
566
审稿时长
2-4 weeks
期刊介绍: ​​The Pediatric Infectious Disease Journal® (PIDJ) is a complete, up-to-the-minute resource on infectious diseases in children. Through a mix of original studies, informative review articles, and unique case reports, PIDJ delivers the latest insights on combating disease in children — from state-of-the-art diagnostic techniques to the most effective drug therapies and other treatment protocols. It is a resource that can improve patient care and stimulate your personal research.
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