Crosstalk Between Innate Immunity and Autophagy in Viral Myocarditis Leading to Dilated Cardiomyopathy.

IF 9 2区 医学 Q1 VIROLOGY Reviews in Medical Virology Pub Date : 2024-11-01 DOI:10.1002/rmv.2586
Chen Wang, Honglin Luo
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Abstract

Viral myocarditis, characterised by inflammation of the heart muscle, presents a significant challenge to global public health, particularly affecting younger individuals and often progressing to dilated cardiomyopathy (DCM), a leading cause of heart failure. Despite ongoing research efforts, viable treatments for this condition remain elusive. Recent studies have shed light on the complex interplay between the innate immune response and autophagy mechanisms, revealing their pivotal roles in the pathogenesis of viral myocarditis and subsequent DCM development. This review aims to delve into the recent advancements in understanding the molecular mechanisms and pathways that intersect innate immunity and autophagy in the context of viral myocarditis. Furthermore, it explores the potential therapeutic implications of these findings, offering insights into promising avenues for the management and treatment of this debilitating condition.

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病毒性心肌炎导致扩张型心肌病的先天性免疫与自噬之间的相互关系
病毒性心肌炎以心肌发炎为特征,是全球公共卫生面临的一项重大挑战,尤其影响年轻人,并经常发展为扩张型心肌病(DCM),这是心力衰竭的主要原因。尽管研究工作一直在进行,但针对这一病症的可行治疗方法仍然遥遥无期。最近的研究揭示了先天性免疫反应和自噬机制之间复杂的相互作用,揭示了它们在病毒性心肌炎的发病机制和随后的扩张性心肌病发展中的关键作用。本综述旨在深入探讨最近在了解病毒性心肌炎中先天性免疫和自噬相互交织的分子机制和途径方面取得的进展。此外,它还探讨了这些发现的潜在治疗意义,为管理和治疗这种使人衰弱的疾病提供了有希望的途径。
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来源期刊
Reviews in Medical Virology
Reviews in Medical Virology 医学-病毒学
CiteScore
21.40
自引率
0.90%
发文量
88
期刊介绍: Reviews in Medical Virology aims to provide articles reviewing conceptual or technological advances in diverse areas of virology. The journal covers topics such as molecular biology, cell biology, replication, pathogenesis, immunology, immunization, epidemiology, diagnosis, treatment of viruses of medical importance, and COVID-19 research. The journal has an Impact Factor of 6.989 for the year 2020. The readership of the journal includes clinicians, virologists, medical microbiologists, molecular biologists, infectious disease specialists, and immunologists. Reviews in Medical Virology is indexed and abstracted in databases such as CABI, Abstracts in Anthropology, ProQuest, Embase, MEDLINE/PubMed, ProQuest Central K-494, SCOPUS, and Web of Science et,al.
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