B. Van Mol , M. Oosterlinck , S. Janssens , N. Buys , F. Pille
{"title":"Environmental factors of equine osteochondrosis and fetlock osteochondral fragments: A scoping review – Part 1","authors":"B. Van Mol , M. Oosterlinck , S. Janssens , N. Buys , F. Pille","doi":"10.1016/j.tvjl.2024.106249","DOIUrl":null,"url":null,"abstract":"<div><div>Various environmental and genetic risk factors are linked to the pathogenesis of equine osteochondrosis and osteochondral fragments in the fetlock joint. Therefore, a scoping review was conducted to describe current evidence linking genetic factors and environmental factors of these osteochondral disorders. This article constitutes the first part of this scoping review and focuses on environmental factors, with the second part addressing genetic factors. To identify potentially relevant papers online bibliographical databases PubMed and Web of Science were utilised, supplemented with articles listed on the OMIA website (OMIA:000750–9796). After entry collection, removing duplicates, screening titles, abstracts, and full-text documents for eligibility, and manually searching reference lists of the remaining articles, a total of 212 studies was identified for this scoping review. First, an overview of the current understanding of the etiopathogenesis of equine osteochondrosis and osteochondral fragments in the fetlock joint is given. Subsequently, the article delves into the environmental factors associated with the prevalence of these disorders, which are categorized into foetal programming, biomechanical trauma and exercise, growth, anatomic conformation, nutrition, weaning, hormonal factors, bacterial infection, sex, date of birth, and other environmental factors. In conclusion, future research should adopt a multidisciplinary approach, emphasizing longitudinal studies and precise phenotype definitions. This strategy will help elucidate the complex relationships between environmental factors and OC, DOF, and POF, considering the dynamic nature, varying phenotypes, and scarcity of research in some domains of these osteochondral disorders. This approach will be crucial in developing effective management strategies aimed at improving equine orthopaedic health.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary journal","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1090023324001886","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Various environmental and genetic risk factors are linked to the pathogenesis of equine osteochondrosis and osteochondral fragments in the fetlock joint. Therefore, a scoping review was conducted to describe current evidence linking genetic factors and environmental factors of these osteochondral disorders. This article constitutes the first part of this scoping review and focuses on environmental factors, with the second part addressing genetic factors. To identify potentially relevant papers online bibliographical databases PubMed and Web of Science were utilised, supplemented with articles listed on the OMIA website (OMIA:000750–9796). After entry collection, removing duplicates, screening titles, abstracts, and full-text documents for eligibility, and manually searching reference lists of the remaining articles, a total of 212 studies was identified for this scoping review. First, an overview of the current understanding of the etiopathogenesis of equine osteochondrosis and osteochondral fragments in the fetlock joint is given. Subsequently, the article delves into the environmental factors associated with the prevalence of these disorders, which are categorized into foetal programming, biomechanical trauma and exercise, growth, anatomic conformation, nutrition, weaning, hormonal factors, bacterial infection, sex, date of birth, and other environmental factors. In conclusion, future research should adopt a multidisciplinary approach, emphasizing longitudinal studies and precise phenotype definitions. This strategy will help elucidate the complex relationships between environmental factors and OC, DOF, and POF, considering the dynamic nature, varying phenotypes, and scarcity of research in some domains of these osteochondral disorders. This approach will be crucial in developing effective management strategies aimed at improving equine orthopaedic health.
各种环境和遗传风险因素都与马骨软骨病和跗关节骨软骨碎片的发病机制有关。因此,我们进行了一次范围界定综述,以描述当前将这些骨软骨疾病的遗传因素和环境因素联系起来的证据。本文是该范围界定综述的第一部分,主要讨论环境因素,第二部分讨论遗传因素。为了确定潜在的相关论文,我们利用了在线文献数据库 PubMed 和 Web of Science,并辅以 OMIA 网站(OMIA:000750-9796)上列出的文章。经过条目收集、删除重复文章、筛选标题、摘要和全文文件以确定是否符合条件,以及人工检索其余文章的参考文献目录,本次范围界定综述共确定了 212 项研究。首先,文章概述了目前对马跗关节骨软骨病和骨软骨碎片病因发病机制的理解。随后,文章深入探讨了与这些疾病的发病率相关的环境因素,这些因素可分为胎儿程序、生物力学创伤和运动、生长、解剖构造、营养、断奶、激素因素、细菌感染、性别、出生日期以及其他环境因素。总之,未来的研究应采用多学科方法,强调纵向研究和精确的表型定义。考虑到这些骨软骨疾病的动态性质、不同表型以及某些领域研究的稀缺性,这一策略将有助于阐明环境因素与 OC、DOF 和 POF 之间的复杂关系。这种方法对于制定有效的管理策略以改善马骨科健康至关重要。
期刊介绍:
The Veterinary Journal (established 1875) publishes worldwide contributions on all aspects of veterinary science and its related subjects. It provides regular book reviews and a short communications section. The journal regularly commissions topical reviews and commentaries on features of major importance. Research areas include infectious diseases, applied biochemistry, parasitology, endocrinology, microbiology, immunology, pathology, pharmacology, physiology, molecular biology, immunogenetics, surgery, ophthalmology, dermatology and oncology.