Comparative Effects of Candesartan Versus Enalapril on Apelin, Visfatin, and Lipid Levels in Non-obese Hypertensive Patients.

IF 1.1 Q2 MEDICINE, GENERAL & INTERNAL Medeniyet medical journal Pub Date : 2024-09-30 DOI:10.4274/MMJ.galenos.2024.16098
Yaseen K Jumaah, Zainab H Fathi, Jehan A Mohammad
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Abstract

Objective: Apelin and visfatin are adipokines secreted from adipose tissue that play important roles in regulating blood pressure. Therefore, the current study aimed to investigate the effects of candesartan versus enalapril on apelin, visfatin, and lipid profiles in hypertensive patients.

Methods: In this case-control study, 120 participants were enrolled in four groups; Healthy people, newly diagnosed hypertensive patients, and enalapril- and candesartan-treated patients.

Results: Serum apelin levels were significantly lower and visfatin levels were significantly higher in newly diagnosed hypertensive patients compared with the control group (p=0.0015, p=0.0175 respectively). Moreover, apelin levels were higher and visfatin levels were lower in the candesartan-treated patients compared with the newly diagnosed group (p=0.0487, p<0.0001 respectively). Interestingly, apelin levels were non-significantly higher and visfatin levels were significantly lower in enalapril-treated patients compared with the newly diagnosed group (p<0.0001).

Conclusions: Lower apelin and higher visfatin levels are associated with newly diagnosed patients with hypertension. Interestingly, the findings suggest that ACE inhibition and angiotensin receptor blockade by enalapril and candesartan, respectively, positively regulate apelin and visfatin levels in hypertension. Specifically, candesartan regulates these adipokine to a greater extent than enalapril.

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坎地沙坦与依那普利对非肥胖高血压患者胰岛素、血管紧张素和血脂水平的比较效应
目的杏仁蛋白和粘脂蛋白是脂肪组织分泌的脂肪因子,在调节血压方面发挥着重要作用。因此,本研究旨在探讨坎地沙坦与依那普利相比对高血压患者胰岛素、粘蛋白和血脂的影响:在这项病例对照研究中,120 名参与者分为四组:健康人、新诊断的高血压患者、依那普利和坎地沙坦治疗的患者:结果:与对照组相比,新诊断的高血压患者血清凋亡素水平明显降低,粘蛋白水平明显升高(p=0.0015,p=0.0175)。此外,与新诊断组相比,接受坎地沙坦治疗的患者血清凋亡素水平较高,粘脂水平较低(P=0.0487,P=0.0175):新诊断的高血压患者凋亡素水平较低,粘脂水平较高。有趣的是,研究结果表明,依那普利和坎地沙坦分别抑制 ACE 和阻断血管紧张素受体,对高血压患者的凋亡磷脂和粘蛋白水平有积极的调节作用。具体而言,坎地沙坦对这些脂肪因子的调节作用大于依那普利。
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来源期刊
Medeniyet medical journal
Medeniyet medical journal Medicine-Medicine (all)
CiteScore
1.70
自引率
0.00%
发文量
88
审稿时长
5 weeks
期刊介绍: The Medeniyet Medical Journal (Medeniyet Med J) is an open access, peer-reviewed, and scientific journal of Istanbul Medeniyet University Faculty of Medicine on various academic disciplines in medicine, which is published in English four times a year, in March, June, September, and December by a group of academics. Medeniyet Medical Journal is the continuation of Göztepe Medical Journal (ISSN: 1300-526X) which was started publishing in 1985. It changed the name as Medeniyet Medical Journal in 2015. Submission and publication are free of charge. No fees are asked from the authors for evaluation or publication process. All published articles are available online in the journal website (www.medeniyetmedicaljournal.org) without any fee. The journal publishes intradisciplinary or interdisciplinary clinical, experimental, and basic researches as well as original case reports, reviews, invited reviews, or letters to the editor, Being published since 1985, the Medeniyet Med J recognizes that the best science should lead to better lives based on the fact that the medicine should serve to the needs of society, and knowledge should transform society. The journal aims to address current issues at both national and international levels, start debates, and exert an influence on decision-makers all over the world by integrating science in everyday life. Medeniyet Med J is committed to serve the public and influence people’s lives in a positive way by making science widely accessible. Believing that the only goal is improving lives, and research has an impact on people’s lives, we select the best research papers in line with this goal.
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