Medeniyet medical journal最新文献

Objective: This study aimed to compare the effectiveness of different mesotherapy techniques applied at various dermal depths on pain, functional status, and quality of life in patients with non-specific neck pain.

Methods: A total of 43 patients who received mesotherapy for non-specific neck pain were retrospectively analyzed. Patients treated with the point-by-point technique (n=21) and the napaj technique (n=22) were recorded. A mixture of 2 mL lidocaine and tenoxicam was used as the mesotherapy solution. Pain was assessed using the visual analog scale (VAS), functional status was assessed using the neck disability index (NDI), and quality of life was assessed using the Nottingham health profile before (T0), after (T1), and 3 months after (T2).

Results: In both groups, which were homogeneous in terms of demographic data, statistically significant changes were observed in T1 and T2 values compared with T0 for all evaluation parameters (p=0.001). While both groups demonstrated improvement in all parameters, the posttreatment VAS and NDI score in the point-by-point group was slightly better than that in the napaj group (p=0.042), (p=0.043) but this difference disappeared in the 3-month evaluation.

Conclusions: Mesotherapy using a lidocaine-tenoxicam mixture with both the point-by-point and napaj techniques is an effective and safe treatment method for nonspecific neck pain. Both techniques were found to be effective in improving pain, functional status, and quality of life, but neither technique was found to be superior to the other.

Objective: This study aims to compare the results of cases with a history of assault presented to our emergency department over a period of three years with literature data and to share our experiences with colleagues.

Methods: Demographic characteristics, trauma findings, clinical conditions, surgical interventions, mortality, and outcomes of patients with a history of assault to the emergency department between 2020 and 2022 were retrospectively examined. The results were analyzed using the Number Cruncher Statistical System 2007 Statistical Software package program (Utah, USA).

Results: A total of 2900 patients, including 1850 males (63.79%) and 1050 females (36.21%), with an average age of 35.53±12.46 years, were included in the study. Most admissions (31.28%) occurred during the summer months and outside working hours. Males inflicted all injuries. The most common injuries occurred in the head-neck region (63.31%) and upper extremities (47.97%) in both sexes. Facial injuries were significantly more common in males (p=<0.05), whereas spinal and pelvic injuries were common in females (p<0.05). Tenderness, edema, hematoma, abrasion, ecchymosis, and soft tissue laceration were the most frequently observed findings. Female patients were more likely to be discharged home (p=0.0001), whereas male patients had a higher hospitalization rate (p=0.0001). Life-threatening ailments were discovered in 23 patients (0.79%). Surgical intervention was performed in 50 patients (1.72%). No patient experienced fatal outcomes.

Conclusions: All assaults were committed by males. Males are more frequently and severely assaulted than females. The victims were mainly from young people, and assaults predominantly occurred during the summer months and outside working hours. Head-neck and extremity injuries were the most common. There were no fatal outcomes. Nine of the 10 patients were discharged to home from the emergency department.

Objective: This study aimed to assess the functional and clinical outcomes of endoscopic Type 1 tympanoplasty in patients with chronic otitis media and tympanic membrane perforations, focusing on hearing improvement and graft success rates.

Methods: This retrospective study included 46 patients with dry tympanic membrane perforations who underwent endoscopic Type 1 tympanoplasty. Audiometric data, including pure tone averages (PTA) and air-bone gap (ABG) measurements at four frequencies (500, 1000, 2000, and 4000 Hz), were collected preoperatively and postoperatively. Functional success was defined as a postoperative ABG of 20 dB, whereas the integrity of the graft determined clinical success.

Results: The mean preoperative ABG was 36.74±7.62 dB, which significantly improved to 15.05±3.82 dB postoperatively (p<0.001). The PTA exhibited an average gain of 28.17±6.87 dB for all frequencies. Functional success was achieved in 42 patients (91.30%), with 17 patients (36.96%) achieving normal hearing and 22 patients (47.83%) presenting with slight hearing loss postoperatively. Anatomical success was achieved in 42 patients (91.30%).

Conclusions: Endoscopic Type 1 tympanoplasty is a safe and effective surgical method for treating chronic otitis media, with high rates of both functional and clinical success, significant improvements in hearing outcomes, and minimal postoperative complications.

Objective: Methotrexate (MTX) is a highly effective chemotherapy for cancer. This drug has a gonadotoxic effect, mainly in the testes and ovaries. Our study used histopathological and immunohistochemical methods to assess the potential damage to testicular and ovarian tissue caused by MTX use.

Methods: Twenty-four Wistar albino rats, both male and female, were used in our study. Four sets of rats; control male, MTX male, control female, and MTX female were created. The male and female MTX-treated groups received a single intraperitoneal dose of 20 mg/kg MTX. The testes and ovaries of rats sacrificed under general anesthesia were extracted and histopathologically analyzed. In addition, the immunoreactivity intensities of stem cell factor (SCF), mechanistic target of rapamycin (mTOR), and SIRT-1 in both tissues were measured by immunohistochemistry.

Results: Johnsen's testicular biopsy score in the testicular seminiferous tubules was significantly lower in the MTX group than in the control group (p<0.001). The ovary showed substantial follicular degeneration (p<0.05), vascular congestion (p<0.01), and fibrosis (p<0.001). MTX reduced SCF immunoreactivity density in the testis and ovary (p<0.05). Furthermore, MTX reduced mTOR, a marker of autophagy, in the testis (p<0.05) and ovary (p<0.001) compared with the control. SIRT-1 intensity increased dramatically in the testis (p<0.001) and ovary (p<0.01) in the injured group, unlike the mTOR marker.

Conclusions: Our investigation revealed that the gonads incurred significant damage as a result of MTX. One vital option for reducing or eliminating this damage to the ovaries and testicles is the use of anti-oxidant-rich substances.

Objective: Chronic kidney disease (CKD) is a prominent public health concern, is defined as functional and structural damage to the kidneys. This study aims to investigate the association between human leukocyte antigen (HLA) alleles individuals with CKD and the different etiological subgroups of diesease.

Methods: Genomic DNA was obtained from peripheral blood samples of 1,079 patients with retrospective CKD and 1,111 healthy control individuals. HLA genotyping was conducted using the Luminex based low-resolution method. Allele frequency distributions were calculated with the help of Arlequin v3.11 population genetics statistics program and SPSS v23.0 program, and p<0.05 values were accepted as significant by chi-square tests.

Results: HLA A*02 (21.83%), B*35 (18.30%), DRB1*11 (21.41%) alleles were observed most frequently in individuals with CKD, respectively. In our study, B*08, B*49, B*50 alleles in the HLA B locus (p=0.002, p=0.012 p=0.009) and DRB1*03, *04 alleles in the HLA DRB1 locus (p<0.001, p<0.001) were found positively associated with CKD. A*02, A*11, A*74 alleles at the HLA A locus (p=0.003, p<0.001, p=0.009) and B*27, B*39, B* alleles at the HLA B locus 40, B*59 (p<0.001, p<0.001, p<0.001, p=0.009), DRB1*07, *08, *09, *13, *16 (p<0.001, p=0.012, p=0.007, p<0.001, p<0.001) alleles were determined as negatively associated with the disease. Among the etiological groups of CKD, cystic kidney disease (36.8%), hypertension (16.8%) and urological anomalies (16.6%) were negatively associated with the HLA-DR*13 allele.

Conclusions: Since CKD shows serious morbidity and mortality, this comprehensive study of HLA subgroups gave an explanatory idea about which alleles associated with the disease in terms of susceptibility and protection.

Objective: Angiotropism/perivascular invasion (PVI) is an emerging topic in various types of cancer, with studies primarily focusing on melanoma. However, limited data are available on the significance of PVI in breast cancer. This study aimed to assess the prognostic significance of PVI in breast cancer and its correlation with traditional clinicopathological prognostic parameters.

Methods: A total of 150 patients with breast cancer diagnosed between July 2020 and January 2022 were included. Clinicopathological data were retrieved from the hospital records. The presence of PVI was evaluated on hematoxylin&eosin stained slides, and the association between PVI and clinicopathological parameters was statistically analyzed. A p-value of <0.05 was regarded as statistically significant.

Results: All patients were female. The mean age was 54.0±13.6 years (range 26-97 years). PVI was significantly more common in patients with ≥2.5 cm tumors and the absence of PVI showed a significant correlation with a lower histologic grade (p=0.004 and p=0.040, respectively). Lymphovascular invasion (LVI) and perineural invasion (PNI) were also significantly more frequent in tumors with PVI (p=0.001 and 0.02, respectively). There was a statistically significant association between the absence of both PVI and extranodal extension (ENE) (p=0.035).

Conclusions: The specific role of PVI in different types of cancer has not yet been clarified. Our findings showed that PVI was significantly associated with tumor size, histological grade, LVI, PNI, and ENE, all of which are well-known negative prognostic factors in breast cancer. The presence of PVI is a promising topic in breast cancer research, and the PVI status in pathology reports may help oncologists perform better risk assessments for patients with breast carcinoma.

Objective: In this study, the aim was to evaluate the diagnostic effectiveness of more easily applicable and cost-effective serum biomarkers, such as neutrophil-to-lymphocyte ratio (NLR), platelet-tolymphocyte ratio (PLR), C-reactive protein (CRP) to albumin ratio (CAR), and CRP-to-lymphocyte ratio (CLR), instead of the endoscopic activity index (EAI) used to determine disease activation in ulcerative colitis (UC) patients.

Methods: Blood tests performed during the same period as colonoscopy were reviewed, and NLR, PLR, CAR, and CLR values were calculated. Based on the EAI score, patients with a score <4 were classified as having UC in remission, those with a score ≥4 as having active UC, and those with normal colonoscopy results as the control group.

Results: The study included 66 patients with active UC, 31 with UC in remission, and 99 controls. The CLR and CAR values of active and remission UC patients were found to be higher compared with the control group (p<0.001), while no significant difference was found between the groups in terms of PLR and NLR values (p>0.05). The AUC calculated for CLR in diagnosing active UC was significant (p<0.001), and the best cut-off value was determined as >1,75. For CAR, the best cut-off value was calculated as >0.11.

Conclusions: This study demonstrated that the CLR and CAR had high sensitivity and specificity for detecting UC activity, whereas the PLR and NLR had low diagnostic value.