{"title":"Techno-economic insights into one-pot bacterial astaxanthin extraction and sustainable therapeutic product development using natural solvent mixtures","authors":"","doi":"10.1016/j.seppur.2024.129926","DOIUrl":null,"url":null,"abstract":"<div><div>The increasing demand for sustainable and safe products is driving the replacement of synthetic pigments with natural alternatives in the cosmetics industry. Additionally, the use of green solvents, such as natural solvent mixtures (NaSoMix), is essential to minimize the environmental impact of extraction processes. This study explores the innovative application of NaSoMix for extracting astaxanthin-rich extracts (ARE) from the bacterium <em>Paracoccus carotinifaciens</em>, a promising source of natural colorants and antioxidants. By employing menthol-based natural deep eutectic solvents (NaDES) combined with bio-based solvents, <em>viz</em>., ethyl acetate and ethanol, the research achieved remarkable ARE extraction yields of up to 1.3 mg/mL using conventional procedures. Notably, process intensification through microwave-assisted extraction resulted in a 400 % increase in ARE recovery yields compared to traditional methods. The therapeutic soaps formulated with these ARE extracts exhibited significant antioxidant activity, achieving a 75 % reduction in DPPH• free radical signals, and maintained excellent color stability over a month, with minimal perceptual changes. Safety assessments confirmed the non-irritating properties of the therapeutic soaps, with an irritation score of 0 at low ARE concentrations. Furthermore, an economic analysis revealed a highly favorable Internal Rate of Return (IRR) of 183 % and a Return on Investment (ROI) of 2890 %, underscoring the commercial viability of this sustainable approach. Overall, this study highlights the effectiveness and safety of utilizing NaSoMix for extracting high-value compounds and formulating innovative therapeutic cosmetic products, aligning with consumer preferences for natural ingredients while promoting environmental sustainability and economic feasibility.</div></div>","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":null,"pages":null},"PeriodicalIF":8.1000,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Separation and Purification Technology","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1383586624036657","RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, CHEMICAL","Score":null,"Total":0}
引用次数: 0
Abstract
The increasing demand for sustainable and safe products is driving the replacement of synthetic pigments with natural alternatives in the cosmetics industry. Additionally, the use of green solvents, such as natural solvent mixtures (NaSoMix), is essential to minimize the environmental impact of extraction processes. This study explores the innovative application of NaSoMix for extracting astaxanthin-rich extracts (ARE) from the bacterium Paracoccus carotinifaciens, a promising source of natural colorants and antioxidants. By employing menthol-based natural deep eutectic solvents (NaDES) combined with bio-based solvents, viz., ethyl acetate and ethanol, the research achieved remarkable ARE extraction yields of up to 1.3 mg/mL using conventional procedures. Notably, process intensification through microwave-assisted extraction resulted in a 400 % increase in ARE recovery yields compared to traditional methods. The therapeutic soaps formulated with these ARE extracts exhibited significant antioxidant activity, achieving a 75 % reduction in DPPH• free radical signals, and maintained excellent color stability over a month, with minimal perceptual changes. Safety assessments confirmed the non-irritating properties of the therapeutic soaps, with an irritation score of 0 at low ARE concentrations. Furthermore, an economic analysis revealed a highly favorable Internal Rate of Return (IRR) of 183 % and a Return on Investment (ROI) of 2890 %, underscoring the commercial viability of this sustainable approach. Overall, this study highlights the effectiveness and safety of utilizing NaSoMix for extracting high-value compounds and formulating innovative therapeutic cosmetic products, aligning with consumer preferences for natural ingredients while promoting environmental sustainability and economic feasibility.
期刊介绍:
Separation and Purification Technology is a premier journal committed to sharing innovative methods for separation and purification in chemical and environmental engineering, encompassing both homogeneous solutions and heterogeneous mixtures. Our scope includes the separation and/or purification of liquids, vapors, and gases, as well as carbon capture and separation techniques. However, it's important to note that methods solely intended for analytical purposes are not within the scope of the journal. Additionally, disciplines such as soil science, polymer science, and metallurgy fall outside the purview of Separation and Purification Technology. Join us in advancing the field of separation and purification methods for sustainable solutions in chemical and environmental engineering.