Autoimmunity's enigmatic role: exploring the connection with myalgic encephalomyelitis/chronic fatigue syndrome.

IF 2.9 4区 医学 Q3 IMMUNOLOGY BMC Immunology Pub Date : 2024-10-01 DOI:10.1186/s12865-024-00657-5
Jacob Batham, Jessica Dwyer, Natalie Eaton-Fitch, Sonya Marshall-Gradisnik
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Abstract

Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complicated, heterogeneous condition distinguished by post-exertional neuroimmune exhaustion and multisystem symptoms. Its complexity poses challenges for physicians, researchers and those inflicted by its presence. Due to conflicting evidence and limiting consensus, the association and contribution autoimmunity serves in the pathophysiology or aetiology of ME/CFS is yet to be confirmed. This systematic review synthesises the currently available data to clarify the role autoimmunity has in the pathogenesis of ME/CFS and explore the therapeutic limitations.

Methods: This systematic review was conducted in accordance with the PRISMA and Cochrane guidelines. Full-text articles containing the primary key terms "Autoimmunity/Autoimmune" and "ME/CFS" were included provided their suitability to the inclusion and exclusion criteria.

Results: Ten publications investigating the role of autoimmunity in ME/CFS were examined. One investigated the role of cytokine signalling; Three investigated the genetic nature of autoimmunity in ME/CFS patients; One examined the immune lineage of ME/CFS patients; Six investigated the presence and role of autoantibodies in ME/CFS patients.

Conclusion: The findings generated from this systematic review highlight inconsistent and insufficient evidence to classify ME/CFS as an autoimmune disease. Additionally, it further emphasises the complexity of ME/CFS and highlights the challenges in distinguishing autoreactivity from deregulatory processes. Future research is urgently needed to advance the development of diagnostic and treatment strategies.

Prospero registration code: CRD42024533447.

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自身免疫的神秘作用:探索与肌痛性脑脊髓炎/慢性疲劳综合征的联系。
背景:肌痛性脑脊髓炎/慢性疲劳综合征(ME/CFS)是一种复杂的异质性疾病,以运动后神经免疫衰竭和多系统症状为特征。它的复杂性给医生、研究人员和患者带来了挑战。由于证据相互矛盾、共识有限,自身免疫在 ME/CFS 病理生理学或病因学中的关联和作用仍有待证实。本系统性综述综合了目前可用的数据,以阐明自身免疫在 ME/CFS 发病机制中的作用,并探讨其治疗局限性:本系统综述根据 PRISMA 和 Cochrane 指南进行。只要符合纳入和排除标准,就会纳入包含主要关键词 "自身免疫/自身免疫 "和 "ME/CFS "的全文文章:结果:研究了10篇调查自身免疫在ME/CFS中作用的文章。其中一篇研究了细胞因子信号的作用;三篇研究了ME/CFS患者自身免疫的遗传性质;一篇研究了ME/CFS患者的免疫系统;六篇研究了ME/CFS患者自身抗体的存在和作用:本系统综述的研究结果表明,将ME/CFS归类为自身免疫性疾病的证据并不一致,也不充分。此外,它还进一步强调了ME/CFS的复杂性,并突出了区分自身反应和失调过程所面临的挑战。未来迫切需要开展研究,以推动诊断和治疗策略的发展:CRD42024533447。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMC Immunology
BMC Immunology 医学-免疫学
CiteScore
5.50
自引率
0.00%
发文量
54
审稿时长
1 months
期刊介绍: BMC Immunology is an open access journal publishing original peer-reviewed research articles in molecular, cellular, tissue-level, organismal, functional, and developmental aspects of the immune system as well as clinical studies and animal models of human diseases.
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