Lenticulostriatal Ischemia Shows Relevant SSTR Expression on PET/CT Imaging Using the Novel SSTR-Targeting Peptide 18 F-SiTATE.

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Clinical Nuclear Medicine Pub Date : 2024-12-01 Epub Date: 2024-10-02 DOI:10.1097/RLU.0000000000005482

Sophie C Kunte, Lena M Unterrainer, Wolfgang G Kunz, Michael Winkelmann, Simon Lindner, Klaus Jurkschat, Carmen Wängler, Björn Wängler, Ralf Schirrmacher, Peter Bartenstein, Claus Belka, Christian Schichor, Nathalie L Albert, Marcus Unterrainer

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引用次数: 0

Abstract

Abstract: A 64-year-old woman with meningioma presented with left-sided lenticulostriatal ischemia following craniotomy and debulking of a sphenoid wing meningioma. For subsequent radiotherapy planning, an SSTR-targeted PET/CT using the novel ligand 18 F-SiTATE was performed 2.5 months thereafter. The meningioma remnants showed transosseous, intrasellar, and perivascular extension around the internal carotid artery with strong SSTR expression. Moreover, there was focal 18 F-SiTATE uptake in the left caudate and corresponding contrast enhancement due to postischemic blood-brain barrier disruption and reactive SSTR expression. Therefore, increased cortical or subcortical SSTR PET signal may be related to ischemic changes even in the subacute stage after initial stroke.

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使用新型 SSTR 靶向肽 18F-SiTATE 进行 PET/CT 成像时，韧皮部缺血显示出相关的 SSTR 表达。

摘要：一名64岁的女性脑膜瘤患者在进行开颅手术和蝶骨翼脑膜瘤剥除术后出现左侧脑皮质缺血。为了制定后续放疗计划，她在两个半月后使用新型配体 18F-SiTATE 进行了 SSTR 靶向 PET/CT。脑膜瘤残余显示颈内动脉周围的经骨膜、小脑内和血管周围扩展，并有强烈的SSTR表达。此外，由于缺血后血脑屏障破坏和反应性 SSTR 表达，左侧尾状体出现局灶性 18F-SiTATE 摄取和相应的对比度增强。因此，皮质或皮质下SSTR PET信号的增加可能与缺血性改变有关，即使在脑卒中初期的亚急性阶段也是如此。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.