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CXCR4-A Potential Novel Theranostic Target in Adrenocortical Carcinoma.
IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-05-01 Epub Date: 2024-12-30 DOI: 10.1097/RLU.0000000000005656
Amir Nazar, Ashwini Kalshetty, Sandip Basu

Abstract: Adrenocortical carcinoma (ACC) is a highly aggressive malignancy with high recurrence rates and poor prognosis. There are only limited treatment options with poor response rates. ACCs are documented to express chemokine receptor CXCR4, which can be visualized using 68 Ga-pentixafor PET/CT. We herein present a case of ACC with local recurrence and peritoneal metastases, which was well visualized on FDG and pentixafor PET/CT. The high expression of CXCR4 offers the potential of theranostics and targeted endoradiotherapy in patients with metastatic ACC. We also observed thymic rebound to illustrate mild to moderate grade uptake of 68 Ga-pentixafor in this patient.

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引用次数: 0
A Rare Case of Peritoneal Mesothelioma Detected by 18 F-AlF-NOTA-Octreotide PET/CT.
IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-05-01 Epub Date: 2025-01-23 DOI: 10.1097/RLU.0000000000005681
Guozhu Hou, Xin Cheng, Yuanyuan Jiang, Rong Zheng, Xuejuan Wang

Abstract: We present a case of 37-year-old man with multiple masses in the abdominal and pelvic cavity who underwent 18 F-AlF-NOTA-octreotide PET/CT. The masses demonstrated heterogeneously increased uptake on 18 F-AlF-NOTA-octreotide PET/CT and were suggestive of neuroendocrine tumor. However, the histopathological examinations confirmed the masses to be peritoneal mesothelioma. This case indicated that peritoneal mesothelioma should be kept in mind as one of the differential diagnoses for 18 F-AlF-NOTA-octreotide-avid tumors.

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引用次数: 0
Early Perfusion [ 123 I]FP-CIT SPECT Imaging With a 360-degree CZT Camera in Dementia With Lewy Bodies.
IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-05-01 Epub Date: 2025-02-26 DOI: 10.1097/RLU.0000000000005764
Antoine Verger, Laetitia Imbert, Diego Cecchin

Dementia with Lewy bodies (DLB) can be diagnosed through a combination of clinical criteria, the loss of dopaminergic neuron terminals in presynaptic [ 123 I]FP-CIT SPECT dopaminergic imaging, and diffuse [ 18 F]FDG PET hypometabolism, which typically affects also the visual cortex. A 360-degree CZT SPECT systems offer advantages in terms of count sensitivity, and both contrast and energy resolution for perfusion and dopaminergic imaging as compared with conventional SPECT systems. As it happens for PET imaging protocols, a dual-time-window protocol with CZT SPECT imaging was used for a suspected DLB patient to capture both perfusion and dopaminergic states.

{"title":"Early Perfusion [ 123 I]FP-CIT SPECT Imaging With a 360-degree CZT Camera in Dementia With Lewy Bodies.","authors":"Antoine Verger, Laetitia Imbert, Diego Cecchin","doi":"10.1097/RLU.0000000000005764","DOIUrl":"10.1097/RLU.0000000000005764","url":null,"abstract":"<p><p>Dementia with Lewy bodies (DLB) can be diagnosed through a combination of clinical criteria, the loss of dopaminergic neuron terminals in presynaptic [ 123 I]FP-CIT SPECT dopaminergic imaging, and diffuse [ 18 F]FDG PET hypometabolism, which typically affects also the visual cortex. A 360-degree CZT SPECT systems offer advantages in terms of count sensitivity, and both contrast and energy resolution for perfusion and dopaminergic imaging as compared with conventional SPECT systems. As it happens for PET imaging protocols, a dual-time-window protocol with CZT SPECT imaging was used for a suspected DLB patient to capture both perfusion and dopaminergic states.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"466-467"},"PeriodicalIF":9.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor Lesion Uptake of [ 177 Lu]Lu-DOTA-Rituximab in Skeletal and Splenic Disease in Diffuse Large B-Cell Lymphoma.
IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-05-01 Epub Date: 2025-01-29 DOI: 10.1097/RLU.0000000000005695
Yeshwanth Edamadaka, Rahul V Parghane, Sandip Basu

Abstract: Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma, and a sizable fraction of the DLBCL patients presents with advanced, relapsed, and refractory disease, demonstrating poor response to standard chemotherapy regimens. Radioimmunotherapy (RIT) has shown to be clinically effective in refractory DLBCL. We present the case of a patient with DLBCL with [ 18 F]FDG-avid widespread skeletal as well as splenic involvement as poor prognostic extranodal disease on FDG PET/CT. RIT based on [ 177 Lu]Lu-DOTA-rituximab was explored to study the biodistribution and dosimetry of [ 177 Lu]Lu-DOTA-rituximab in CD20-positive lymphoma. An exceptionally high tracer concentration in skeletal and splenic disease was observed, supporting its potential RIT application in relapsed and refractory DLBCL patients in the future.

{"title":"Tumor Lesion Uptake of [ 177 Lu]Lu-DOTA-Rituximab in Skeletal and Splenic Disease in Diffuse Large B-Cell Lymphoma.","authors":"Yeshwanth Edamadaka, Rahul V Parghane, Sandip Basu","doi":"10.1097/RLU.0000000000005695","DOIUrl":"10.1097/RLU.0000000000005695","url":null,"abstract":"<p><strong>Abstract: </strong>Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma, and a sizable fraction of the DLBCL patients presents with advanced, relapsed, and refractory disease, demonstrating poor response to standard chemotherapy regimens. Radioimmunotherapy (RIT) has shown to be clinically effective in refractory DLBCL. We present the case of a patient with DLBCL with [ 18 F]FDG-avid widespread skeletal as well as splenic involvement as poor prognostic extranodal disease on FDG PET/CT. RIT based on [ 177 Lu]Lu-DOTA-rituximab was explored to study the biodistribution and dosimetry of [ 177 Lu]Lu-DOTA-rituximab in CD20-positive lymphoma. An exceptionally high tracer concentration in skeletal and splenic disease was observed, supporting its potential RIT application in relapsed and refractory DLBCL patients in the future.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e292-e293"},"PeriodicalIF":9.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arterial Occlusion in Takayasu Arteritis Detected as a Blood Pool Defect on 18 F-FDG Semiconductor PET/CT.
IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-05-01 Epub Date: 2025-02-11 DOI: 10.1097/RLU.0000000000005701
Masahiro Koyama, Yohji Matsusaka, Kaho Watanabe, Akira Seto, Ichiei Kuji

Abstract: A 75-year-old woman with Takayasu arteritis was referred to 18 F-FDG PET/CT due to elevated C-reactive protein in her laboratory data. FDG PET/CT with semiconductor detectors revealed no uptake in the arterial walls, suggesting active inflammation. However, the blood pool uptake in the proximal portion of the left subclavian artery was defective, suggesting arterial occlusion. Magnetic resonance angiography revealed complete occlusion of the left subclavian artery. Ultrasonography showed the reverse flow of the left vertebral artery. Semiconductor PET can visualize the blood pool defects of the intra-arterial uptake in the arterial branches from the aorta.

{"title":"Arterial Occlusion in Takayasu Arteritis Detected as a Blood Pool Defect on 18 F-FDG Semiconductor PET/CT.","authors":"Masahiro Koyama, Yohji Matsusaka, Kaho Watanabe, Akira Seto, Ichiei Kuji","doi":"10.1097/RLU.0000000000005701","DOIUrl":"10.1097/RLU.0000000000005701","url":null,"abstract":"<p><strong>Abstract: </strong>A 75-year-old woman with Takayasu arteritis was referred to 18 F-FDG PET/CT due to elevated C-reactive protein in her laboratory data. FDG PET/CT with semiconductor detectors revealed no uptake in the arterial walls, suggesting active inflammation. However, the blood pool uptake in the proximal portion of the left subclavian artery was defective, suggesting arterial occlusion. Magnetic resonance angiography revealed complete occlusion of the left subclavian artery. Ultrasonography showed the reverse flow of the left vertebral artery. Semiconductor PET can visualize the blood pool defects of the intra-arterial uptake in the arterial branches from the aorta.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"440-441"},"PeriodicalIF":9.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Somatostatin Receptor-Directed Theranostics in Esthesioneuroblastoma.
IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-05-01 Epub Date: 2025-03-03 DOI: 10.1097/RLU.0000000000005717
Yingjun Zhi, Sebastian E Serfling, Daniel Groener, Philipp E Hartrampf, Takahiro Higuchi, Matthias Scheich, Stephan Hackenberg, Andreas K Buck, Joachim P Steinbach, Rudolf A Werner, Konrad Klimek, Marinela Augustin

Background: We aim to report on somatostatin receptor (SSTR)-targeted molecular imaging and therapy in patients with advanced esthesioneuroblastoma (ENB).

Patients and methods: Five patients with ENB [Kadish stage D in 5/5 (100%); Hyams grade 2 in 2/5 (40%), grade 3 in 2/5 (40%), undetermined in 1/5 (20%)] underwent SSTR-directed PET/CT. We quantified SSTR-avid tumor volume (TV), maximum SUV (SUV max ), and target-to-background ratios (TBR). Based on imaging, peptide receptor radionuclide therapy (PRRT) along with dosimetry was also conducted. We recorded nephrotoxicity and hematotoxicity, including estimated glomerular filtration rate (eGFR), hemoglobin, leukocytes, and thrombocytes at baseline and after the last treatment cycle. We determined adverse events following Common Terminology Criteria for Adverse Events (CTCAE) v5.0. Response and progression-free survival (PFS) was also evaluated.

Results: All 5 patients were rated positive on SSTR-PET/CT. On a lesion-based level, we identified 32 SSTR-avid tumor sites with a median TV of 11.7±10.8 and SUV max of 24.3±12.8. TBR was 19.8±9.7, indicating excellent image contrast. After median 4 (range, 2-6) cycles with a median of 7.7 GBq per cycle per patient, we observed no CTCAE grade 3 or 4 toxicity for leukocytes and thrombocytes and no significant CTCAE events for renal function. One patient (20%), however, developed reversible grade 3 anemia. Up to 11.8 Gy in tumor lesions were achieved. Partial response was recorded in 3/5 (60%), stable disease in 1/5 (20%), and progressive disease in 1/5 (20%). The median PFS was 29 weeks.

Conclusions: SSTR-directed PET provided high image contrast in ENB, suggesting good read-out capabilities in this tumor type. PRRT was also feasible, along with an acceptable safety profile, thereby rendering SSTR-targeted theranostics a potential treatment option in advanced disease.

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引用次数: 0
Thyroid Tuberculosis Depicted by 18 F-FAPI PET/CT.
IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-05-01 Epub Date: 2025-03-18 DOI: 10.1097/RLU.0000000000005799
Yuhua Wang, Lei Zhang, Feifei Qiao, Wanchun Zhang

Thyroid tuberculosis is a rare condition that is difficult to diagnose and may be suspected of being a malignant tumor. We report a case of thyroid tuberculosis in a 54-year-old woman that mimicked thyroid cancer on ultrasound, with a 18 F-FAPI PET/CT scan showing intense 18 F-FAPI uptake in the thyroid lobe, right neck lymph node, and celiac lymph nodes.

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引用次数: 0
18 F-FDG PET/CT Revealed Bone Infarction as the Cause of Unexplained Fever. 18F-FDG PET/CT显示骨梗死是不明原因发热的原因。
IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-05-01 Epub Date: 2024-12-23 DOI: 10.1097/RLU.0000000000005637
Xueqi Chen, Qian Li, Zhanli Fu

Abstract: An 18 F-FDG PET/CT was conducted on a 44-year-old man with a history of dermatomyositis and avascular necrosis of left femoral head, due to a fever of unknown origin. The scan revealed patchy and cloudy high densities within the medullary cavities of bilateral distal femur and proximal tibia, exhibiting peripheral high 18 F-FDG avidity. Subsequent MRI confirmed bone infarction.

摘要:本文对一名44岁男性患者进行了18F-FDG PET/CT检查,该患者因不明原因发热,有左股骨头皮肌炎和缺血性坏死病史。扫描显示双侧股骨远端和胫骨近端髓腔内斑片状和浑浊高密度,周围显示高18F-FDG密度。随后的MRI证实骨梗死。
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引用次数: 0
18 F-FDG PET/CT of Intrapulmonary Schwannoma Mimicking Lung Cancer in the Right Lower Lobe. 右下肺模拟肺癌肺内神经鞘瘤的18F-FDG PET/CT表现。
IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-05-01 Epub Date: 2024-12-30 DOI: 10.1097/RLU.0000000000005590
Zhiying Liang, Wei Li

A 53-year-old woman was found to have a soft tissue mass in the right lower lung lobe on chest CT, raising suspicion of lung cancer. For staging, 18 F-FDG PET/CT was performed, which demonstrated intense tracer uptake in the mass (SUV max , 14.6). Subsequently, surgical excision was undertaken, and histopathological examination of the resected specimen confirmed the diagnosis of a schwannoma.

摘要:53岁女性胸部CT示右下肺叶软组织肿块,怀疑肺癌。对于分期,进行了18F-FDG PET/CT检查,显示肿块中有强烈的示踪剂摄取(SUVmax, 14.6)。随后,进行手术切除,切除标本的组织病理学检查证实了神经鞘瘤的诊断。
{"title":"18 F-FDG PET/CT of Intrapulmonary Schwannoma Mimicking Lung Cancer in the Right Lower Lobe.","authors":"Zhiying Liang, Wei Li","doi":"10.1097/RLU.0000000000005590","DOIUrl":"10.1097/RLU.0000000000005590","url":null,"abstract":"<p><p>A 53-year-old woman was found to have a soft tissue mass in the right lower lung lobe on chest CT, raising suspicion of lung cancer. For staging, 18 F-FDG PET/CT was performed, which demonstrated intense tracer uptake in the mass (SUV max , 14.6). Subsequently, surgical excision was undertaken, and histopathological examination of the resected specimen confirmed the diagnosis of a schwannoma.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e294-e296"},"PeriodicalIF":9.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Significantly Elevated FDG Activity in Esophageal Inflammatory Myofibroblastic Tumor of a Pediatric Patient.
IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-05-01 Epub Date: 2025-01-23 DOI: 10.1097/RLU.0000000000005684
Xin Cheng, Liyan Xue, Lin Lin, Jing Li, Xuejuan Wang

Abstract: A 13-year-old girl presented with dysphagia underwent contrast-enhanced CT and endoscopy. The CT revealed cervical esophageal wall thickening with heterogeneous enhancement. Microscopic examination of the biopsy specimen suggested a possible mesenchymal tumor. She underwent an 18 F-FDG PET/CT scan for staging. The scan showed local thickening of the cervical esophageal wall with heterogeneous and significantly elevated FDG activity. Subsequent immunohistochemical staining and fluorescence in situ hybridization confirmed the diagnosis of esophageal inflammatory myofibroblastic tumor.

{"title":"Significantly Elevated FDG Activity in Esophageal Inflammatory Myofibroblastic Tumor of a Pediatric Patient.","authors":"Xin Cheng, Liyan Xue, Lin Lin, Jing Li, Xuejuan Wang","doi":"10.1097/RLU.0000000000005684","DOIUrl":"10.1097/RLU.0000000000005684","url":null,"abstract":"<p><strong>Abstract: </strong>A 13-year-old girl presented with dysphagia underwent contrast-enhanced CT and endoscopy. The CT revealed cervical esophageal wall thickening with heterogeneous enhancement. Microscopic examination of the biopsy specimen suggested a possible mesenchymal tumor. She underwent an 18 F-FDG PET/CT scan for staging. The scan showed local thickening of the cervical esophageal wall with heterogeneous and significantly elevated FDG activity. Subsequent immunohistochemical staining and fluorescence in situ hybridization confirmed the diagnosis of esophageal inflammatory myofibroblastic tumor.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"464-465"},"PeriodicalIF":9.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Clinical Nuclear Medicine
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