Ziziphus jujuba (Jujube) in Metabolic Syndrome: From Traditional Medicine to Scientific Validation.

IF 4.6 3区 医学 Q1 NUTRITION & DIETETICS Current Nutrition Reports Pub Date : 2024-12-01 Epub Date: 2024-10-01 DOI:10.1007/s13668-024-00581-5
Mahboobeh Ghasemzadeh Rahbardar, Homa Fazeli Kakhki, Hossein Hosseinzadeh
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Abstract

Purpose of review: This review evaluates the therapeutic potential of Ziziphus jujuba and its main components in managing complications of metabolic syndrome, including diabetes, dyslipidemia, obesity, and hypertension.

Recent findings: The reviewed studies provide evidence supporting the use of Z. jujuba and its main components (lupeol and betulinic acid) as natural treatments for complications of metabolic syndrome. These substances enhance glucose uptake through the activation of signaling pathways such as phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), reduce hepatic glucose synthesis, and increase glucose uptake by adipocytes and skeletal muscle cells. They also improve insulin sensitivity by modulating AMP-activated protein kinase (AMPK) activity and regulating insulin signaling proteins and glucose transporters. In the field of dyslipidemia, they inhibit triglyceride synthesis, lipid accumulation, and adipogenic enzymes, while influencing key signaling pathways involved in adipogenesis. Z. jujuba and its constituents demonstrate anti-adipogenic effects, inhibiting lipid accumulation and modulating adipogenic enzymes and transcription factors. They also exhibit positive effects on endothelial function and vascular health by enhancing endothelial nitric oxide synthase (eNOS) expression, NO production, and antioxidant enzyme activity. Z. jujuba, lupeol, and betulinic acid hold promise as natural treatments for complications of metabolic syndrome. They improve glucose metabolism, insulin sensitivity, and lipid profiles while exerting anti-adipogenic effects and enhancing endothelial function. However, further research is needed to elucidate the mechanisms and confirm their efficacy in clinical trials. These natural compounds offer potential as alternative therapies for metabolic disorders and contribute to the growing body of evidence supporting the use of natural medicines in their management.

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大枣与代谢综合征:从传统医学到科学验证。
综述目的:本综述评估了酸枣仁及其主要成分在控制糖尿病、血脂异常、肥胖和高血压等代谢综合征并发症方面的治疗潜力:综述研究提供的证据支持使用酸枣仁及其主要成分(羽扇豆醇和白桦脂酸)作为代谢综合征并发症的天然疗法。这些物质通过激活磷脂酰肌醇 3- 激酶 (PI3K)/ 蛋白激酶 B (Akt)等信号通路提高葡萄糖摄取量,减少肝脏葡萄糖合成,增加脂肪细胞和骨骼肌细胞的葡萄糖摄取量。它们还能通过调节 AMP 激活蛋白激酶 (AMPK) 的活性以及调节胰岛素信号蛋白和葡萄糖转运体来提高胰岛素敏感性。在血脂异常领域,它们能抑制甘油三酯的合成、脂质积累和脂肪生成酶,同时影响参与脂肪生成的关键信号通路。酸枣仁及其成分具有抗脂肪生成的作用,可抑制脂质积累,调节脂肪生成酶和转录因子。它们还通过增强内皮一氧化氮合酶(eNOS)的表达、氮氧化物的产生和抗氧化酶的活性,对内皮功能和血管健康产生积极影响。泽泻、羽扇豆醇和白桦脂酸有望成为治疗代谢综合征并发症的天然药物。它们能改善葡萄糖代谢、胰岛素敏感性和血脂状况,同时具有抗脂肪生成的作用,并能增强内皮功能。然而,还需要进一步的研究来阐明其机制,并在临床试验中确认其疗效。这些天然化合物具有作为代谢紊乱替代疗法的潜力,并为越来越多的支持使用天然药物治疗代谢紊乱的证据做出了贡献。
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来源期刊
Current Nutrition Reports
Current Nutrition Reports Agricultural and Biological Sciences-Food Science
CiteScore
7.70
自引率
2.00%
发文量
59
期刊介绍: This journal aims to provide comprehensive review articles that emphasize significant developments in nutrition research emerging in recent publications. By presenting clear, insightful, balanced contributions by international experts, the journal intends to discuss the influence of nutrition on major health conditions such as diabetes, cardiovascular disease, cancer, and obesity, as well as the impact of nutrition on genetics, metabolic function, and public health. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. We also provide commentaries from well-known figures in the field, and an Editorial Board of more than 25 internationally diverse members reviews the annual table of contents, suggests topics of special importance to their country/region, and ensures that topics and current and include emerging research.
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