Association of antenatal steroid administration with neonatal morbidities among late preterm multiple gestation infants.

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY Journal of Perinatology Pub Date : 2024-10-01 DOI:10.1038/s41372-024-02130-y

Pradeep Kumar Velumula, Praveen Kumar Boddu, Luna Khanal, Sanket Jani, Nithi Fernandes, Ronald Thomas, Monika Bajaj, Sanjay Chawla

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Abstract

Background: There is limited evidence on the efficacy of antenatal steroids (ANS) among women with multiple gestations at risk of late preterm delivery.

Study design: This retrospective study included multiple gestation, late preterm infants (34^0/7-36^6/7 weeks' gestational age), born between January 2013 and December 2022. The primary outcome was composite respiratory outcome, defined as the need for respiratory support by 72 hours of age. Logistic and linear regressions were performed to compare the primary and secondary outcomes with and without exposure to any ANS, adjusted for gestational age, sex of infant, histologic chorioamnionitis, and intrauterine growth restriction.

Results: The composite respiratory outcome was significantly lower in any ANS group compared to no ANS group (28.6% vs. 33.7%) [adjusted odds ratio 0.50, 95% CI, 0.33-0.75, p < 0.001].

Conclusion: In late preterm multiple gestation infants, any ANS exposure was associated with lower risk of composite respiratory outcome.

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晚期早产多胎妊娠婴儿产前服用类固醇与新生儿发病率的关系。

背景：在有晚期早产风险的多胎妊娠妇女中，产前类固醇（ANS）的疗效证据有限：这项回顾性研究纳入了2013年1月至2022年12月期间出生的多胎妊娠晚期早产儿（胎龄340/7-366/7周）。研究的主要结果是综合呼吸系统结果，即婴儿出生 72 小时后是否需要呼吸支持。在对胎龄、婴儿性别、组织学绒毛膜羊膜炎和宫内生长受限进行调整后，进行了逻辑回归和线性回归，以比较接触和未接触任何抗逆转录病毒药物的主要和次要结果：结果：与不接触任何抗逆转录病毒药物组相比，接触任何抗逆转录病毒药物组的综合呼吸系统结果明显较低（28.6% 对 33.7%）[调整后的几率比 0.50，95% CI，0.33-0.75，p 结论：在晚期早产多胎妊娠中，接触任何抗逆转录病毒药物组的综合呼吸系统结果明显较低（28.6% 对 33.7%）：在晚期早产多胎妊娠婴儿中，接触任何抗逆转录病毒药物与较低的呼吸系统综合结局风险相关。

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.