Association between probable sarcopenia and dementia risk: a prospective cohort study with mediation analysis.

IF 5.8 1区 医学 Q1 PSYCHIATRY Translational Psychiatry Pub Date : 2024-10-01 DOI:10.1038/s41398-024-03131-3
Yitong Ling, Shiqi Yuan, Xiaxuan Huang, Shanyuan Tan, Hongtao Cheng, Li Li, Shuna Li, Liying Huang, Anding Xu, Jun Lyu
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Abstract

The role of alcohol consumption as a mediator in the risk between sarcopenia and dementia remains inadequately studied. There is currently limited research on whether the association between sarcopenia and the risk of Alzheimer's disease (AD) is influenced by genetic susceptibility. Our study incorporated a total of 483,637 baseline non-dementia participants, who were classified into groups of individuals with no sarcopenia and those with probable sarcopenia based on the definition. We employed Cox proportional hazards models to evaluate the association between probable sarcopenia and the risk of all cause dementia (ACD), AD, and vascular dementia (VD). We conducted mediation analysis to explore the role of alcohol consumption in the association between probable sarcopenia and the risk of ACD, AD, and VD. During the median follow-up period of 13.6 years, we documented 9000 new cases of ACD (including 4061 AD and 2025 VD). Fully adjusted multivariate model revealed a significant correlation between probable sarcopenia and elevated risk for ACD (HR = 1.54, 95% CI: 1.46-1.62, p < 0.001), AD (HR = 1.32, 95% CI: 1.21-1.43, p < 0.001), and VD (HR = 1.69, 95% CI: 1.52-1.89, p < 0.001). Mediation analysis elucidates that alcohol consumption explained 12.8%, 15.2%, and 11.1% of the associations of probable sarcopenia with the risk of ACD, AD, and VD, respectively. An interactive relationship prevails between probable sarcopenia and genetic factors (p for interaction <0.001), and regardless of the degree of genetic risk, probable sarcopenia correlates with an elevated AD risk. Our study reveals a significant association between probable sarcopenia and an increased risk of dementia, with alcohol consumption playing a mediating role in this association. There is an interaction between probable sarcopenia and genetic susceptibility related to the risk of AD.

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可能的肌肉疏松症与痴呆症风险之间的关系:前瞻性队列研究与中介分析。
关于饮酒在肌肉疏松症与痴呆症之间的风险中所起的中介作用,目前研究尚不充分。目前,关于肌肉疏松症与阿尔茨海默病(AD)风险之间的关系是否受遗传易感性影响的研究还很有限。我们的研究共纳入了 483 637 名基线非痴呆症参与者,并根据定义将他们分为无肌肉疏松症和可能患有肌肉疏松症两组。我们采用 Cox 比例危险模型来评估可能的肌肉疏松症与全因痴呆症(ACD)、注意力缺失症(AD)和血管性痴呆症(VD)风险之间的关系。我们还进行了中介分析,以探讨饮酒在可能的肌肉疏松症与全因痴呆症、注意力缺失症和血管性痴呆症风险之间的关联中的作用。在中位 13.6 年的随访期间,我们记录了 9000 例新的 ACD 病例(包括 4061 例 AD 和 2025 例 VD)。经充分调整的多变量模型显示,可能的肌肉疏松症与 ACD 风险升高之间存在显著的相关性(HR = 1.54,95% CI:1.46-1.62,P<0.05)。
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来源期刊
CiteScore
11.50
自引率
2.90%
发文量
484
审稿时长
23 weeks
期刊介绍: Psychiatry has suffered tremendously by the limited translational pipeline. Nobel laureate Julius Axelrod''s discovery in 1961 of monoamine reuptake by pre-synaptic neurons still forms the basis of contemporary antidepressant treatment. There is a grievous gap between the explosion of knowledge in neuroscience and conceptually novel treatments for our patients. Translational Psychiatry bridges this gap by fostering and highlighting the pathway from discovery to clinical applications, healthcare and global health. We view translation broadly as the full spectrum of work that marks the pathway from discovery to global health, inclusive. The steps of translation that are within the scope of Translational Psychiatry include (i) fundamental discovery, (ii) bench to bedside, (iii) bedside to clinical applications (clinical trials), (iv) translation to policy and health care guidelines, (v) assessment of health policy and usage, and (vi) global health. All areas of medical research, including — but not restricted to — molecular biology, genetics, pharmacology, imaging and epidemiology are welcome as they contribute to enhance the field of translational psychiatry.
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