From cyclotrons to chromatography and beyond: a guide to the production and purification of theranostic radiometals

IF 40.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Chemical Society Reviews Pub Date : 2024-10-03 DOI:10.1039/D4CS00802B
Brooke L. McNeil and Caterina F. Ramogida
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Abstract

Recent clinical success with metal-based radiopharmaceuticals has sparked an interest in the potential of these drugs for personalized medicine. Although often overlooked, the success and global impact of nuclear medicine is contingent upon the purity and availability of medical isotopes, commonly referred to as radiometals. For nuclear medicine to reach its true potential and change patient lives, novel production and purification techniques that increase inventory of radiometals are desperately needed. This tutorial review serves as a resource for those both new and experienced in nuclear medicine by providing a detailed explanation of the foundations for the production and purification of radiometals, stemming from nuclear physics, analytical chemistry, and so many other fields, all in one document. The fundamental science behind targetry, particle accelerators, nuclear reactors, nuclear reactions, and radiochemical separation are presented in the context of the field. Finally, a summary of the latest breakthroughs and a critical discussion of the threats and future potential of the most utilized radiometals is also included. With greater understanding of the fundamentals, fellow scientists will be able to better interpret the literature, identify knowledge gaps or problems and ultimately invent new production and purification pathways to increase the global availability of medical isotopes.

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从回旋加速器到色谱法及其他:治疗放射金属的生产和提纯指南。
最近,以金属为基础的放射性药物在临床上取得了成功,激发了人们对这些药物在个性化医疗中的潜力的兴趣。尽管经常被忽视,但核医学的成功和全球影响取决于医用同位素(通常称为放射性同位素)的纯度和可用性。要想发挥核医学的真正潜力并改变病人的生活,就迫切需要能增加放射性同位素库存的新型生产和纯化技术。这本教程综述为核医学领域的新手和经验丰富者提供了资源,它从核物理、分析化学和许多其他领域出发,在一份文件中详细解释了生产和纯化放射性同位素的基础。在该领域的背景下,介绍了打靶、粒子加速器、核反应堆、核反应和放射化学分离背后的基础科学。最后,还总结了最新的突破,并对最常用的放射性金属所面临的威胁和未来潜力进行了批判性讨论。有了对基础知识的进一步了解,科学家同行们将能够更好地解读文献,找出知识差距或问题,并最终发明新的生产和提纯途径,从而提高医用同位素的全球可用性。
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来源期刊
Chemical Society Reviews
Chemical Society Reviews 化学-化学综合
CiteScore
80.80
自引率
1.10%
发文量
345
审稿时长
6.0 months
期刊介绍: Chemical Society Reviews is published by: Royal Society of Chemistry. Focus: Review articles on topics of current interest in chemistry; Predecessors: Quarterly Reviews, Chemical Society (1947–1971); Current title: Since 1971; Impact factor: 60.615 (2021); Themed issues: Occasional themed issues on new and emerging areas of research in the chemical sciences
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