Unveiling therapeutic avenues targeting xCT in head and neck cancer.

IF 6.6 2区 医学 Q1 Medicine Cellular Oncology Pub Date : 2024-10-03 DOI:10.1007/s13402-024-00997-9
Jaewang Lee, Jong-Lyel Roh
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Abstract

Head and neck cancer (HNC) remains a major global health burden, prompting the need for innovative therapeutic strategies. This review examines the role of the cystine/glutamate antiporter (xCT) in HNC, specifically focusing on how xCT contributes to cancer progression through mechanisms such as redox imbalance, ferroptosis, and treatment resistance. The central questions addressed include how xCT dysregulation affects tumor biology and the potential for targeting xCT to enhance treatment outcomes. We explore recent developments in xCT-targeted current and emerging therapies, including xCT inhibitors and novel treatment modalities, and their role in addressing therapeutic challenges. This review aims to provide a comprehensive analysis of xCT as a therapeutic target and to outline future directions for research and clinical application.

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揭示针对头颈部癌症 xCT 的治疗途径。
头颈癌(HNC)仍然是全球主要的健康负担,因此需要创新的治疗策略。这篇综述探讨了胱氨酸/谷氨酸拮抗剂(xCT)在HNC中的作用,特别关注xCT如何通过氧化还原失衡、铁变态反应和耐药性等机制促进癌症进展。研究的核心问题包括 xCT 失调如何影响肿瘤生物学以及靶向 xCT 提高治疗效果的潜力。我们探讨了以 xCT 为靶点的现有疗法和新兴疗法的最新进展,包括 xCT 抑制剂和新型治疗模式,以及它们在应对治疗挑战方面的作用。本综述旨在全面分析作为治疗靶点的xCT,并概述未来的研究和临床应用方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cellular Oncology
Cellular Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research
CiteScore
10.40
自引率
1.50%
发文量
0
审稿时长
16 weeks
期刊介绍: The Official Journal of the International Society for Cellular Oncology Focuses on translational research Addresses the conversion of cell biology to clinical applications Cellular Oncology publishes scientific contributions from various biomedical and clinical disciplines involved in basic and translational cancer research on the cell and tissue level, technical and bioinformatics developments in this area, and clinical applications. This includes a variety of fields like genome technology, micro-arrays and other high-throughput techniques, genomic instability, SNP, DNA methylation, signaling pathways, DNA organization, (sub)microscopic imaging, proteomics, bioinformatics, functional effects of genomics, drug design and development, molecular diagnostics and targeted cancer therapies, genotype-phenotype interactions. A major goal is to translate the latest developments in these fields from the research laboratory into routine patient management. To this end Cellular Oncology forms a platform of scientific information exchange between molecular biologists and geneticists, technical developers, pathologists, (medical) oncologists and other clinicians involved in the management of cancer patients. In vitro studies are preferentially supported by validations in tumor tissue with clinicopathological associations.
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