Prospective observational study on scar sequelae after MPOX infection: an analysis of 40 patients

IF 3.5 4区医学 Q1 DERMATOLOGY International Journal of Dermatology Pub Date : 2024-10-02 DOI:10.1111/ijd.17500

Andrés Grau-Echevarría, Carolina Labrandero-Hoyos, Rodrigo Peñuelas-Leal, Malena Finello, Daniel Blaya-Imbernón, Jorge Magdaleno-Tapial, Ángel González García, Elena Pérez Zafrilla, José Ángel García-García, Laura Giménez Cuenca, Alba Nácher Albiach, José Aguilera Arjona, María Dolores Ocete-Mochón, Esther Díez-Recio, Pablo Hernández-Bel

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Abstract

Background

Monkeypox (MPOX) caused a public health emergency of international concern (PHEIC) outbreak between 2022 and 2023, with a recent rise in cases that prompted the World Health Organization (WHO) to declare the disease a PHEIC once again. There is little information on its long-term scarring sequelae.

Objectives

The objective of this study was to assess the risk and characteristics of scarring in patients with MPOX in a tertiary hospital.

Methods

This is a prospective cohort study including patients diagnosed using polymerase chain reaction (PCR) tests. Clinical data were collected and followed up at 12–15 months to assess scarring and its impact on quality of life.

Results

Of the 40 patients, 19 (47.5%) developed scars, which were more common in those with initial cutaneous manifestations. Scars significantly affected the quality of life, especially in the genital and mucosal areas. The limited sample and loss to follow-up may affect the validity of the results.

Conclusion

Scarring is a frequent and disfiguring sequela of MPOX, particularly in patients with early skin symptoms. Prevention and close follow-up are crucial in mitigating these complications.

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关于 MPOX 感染后疤痕后遗症的前瞻性观察研究：对 40 名患者的分析。

背景：猴痘（MPOX）曾在2022年至2023年期间引发国际关注的突发公共卫生事件（PHEIC），最近病例的增加促使世界卫生组织（WHO）再次宣布该疾病为PHEIC。目前有关该疾病长期瘢痕后遗症的信息很少：本研究旨在评估一家三甲医院的 MPOX 患者出现瘢痕的风险和特征：这是一项前瞻性队列研究，研究对象包括通过聚合酶链反应（PCR）检测确诊的患者。收集临床数据并随访12-15个月，以评估瘢痕及其对生活质量的影响：结果：在 40 名患者中，有 19 人（47.5%）出现疤痕，其中最初有皮肤表现的患者更常见。疤痕严重影响了患者的生活质量，尤其是生殖器和粘膜部位。有限的样本和随访损失可能会影响结果的有效性：结论：疤痕是骨髓增生性白血病常见的毁容性后遗症，尤其是在有早期皮肤症状的患者中。预防和密切随访对减轻这些并发症至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Dermatology 医学-皮肤病学

CiteScore

4.70

自引率

2.80%

发文量

476

审稿时长

3 months

期刊介绍： Published monthly, the International Journal of Dermatology is specifically designed to provide dermatologists around the world with a regular, up-to-date source of information on all aspects of the diagnosis and management of skin diseases. Accepted articles regularly cover clinical trials; education; morphology; pharmacology and therapeutics; case reports, and reviews. Additional features include tropical medical reports, news, correspondence, proceedings and transactions, and education. The International Journal of Dermatology is guided by a distinguished, international editorial board and emphasizes a global approach to continuing medical education for physicians and other providers of health care with a specific interest in problems relating to the skin.