International Journal of Dermatology最新文献

{"title":"Neuropsychiatric Outcomes of IL-17 and IL-23 Inhibitors in Dermatology: Risks, Benefits, and Clinical Implications.","authors":"Isabella J Tan, Alexis Mitelman, Mohammad Jafferany","doi":"10.1111/ijd.70204","DOIUrl":"https://doi.org/10.1111/ijd.70204","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145793850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical Phototherapy Malpractice and Legal Precedents in North America (1983-2025).","authors":"Ghassan Barnawi, Houriah Nukaly, Raquel Lazarowitz, Ammar Saed Aldein, Sarah Kashkari, Saud Aleissa, Mathew Avram","doi":"10.1111/ijd.70223","DOIUrl":"https://doi.org/10.1111/ijd.70223","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145781252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence in Acne Diagnosis and Management: Current Applications and Future Directions.","authors":"Shern-Ping Choy, Sanketh Rampes","doi":"10.1111/ijd.70215","DOIUrl":"https://doi.org/10.1111/ijd.70215","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145774435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunomodulators and Antineoplastics Are Reported in Drug-Associated Epidermolysis Bullosa Acquisita Flares: A Retrospective Analysis of 58 Reported Cases Utilizing Multiple International Pharmacovigilance Databases.","authors":"Gaurav N Pathak, Brandon Tan, Aalia Syed, Dedee F Murrell","doi":"10.1111/ijd.70218","DOIUrl":"https://doi.org/10.1111/ijd.70218","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145774446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Pediatric Atopic Dermatitis in East China and Parental Mental Health Impairment: A Cross-Sectional Questionnaire Study","authors":"Xing Zou,&nbsp;Chao Zhang,&nbsp;Luanluan Li,&nbsp;Dan Deng,&nbsp;Pengjie Wan","doi":"10.1111/ijd.70112","DOIUrl":"10.1111/ijd.70112","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Atopic dermatitis (AD) is the most prevalent chronic recurrent inflammatory skin disease in children. However, there are currently limited epidemiological data on children with AD in East China, and few studies have assessed its impact on parental anxiety and depression. Therefore, we aimed to explore the epidemiology of pediatric AD in Shanghai and its impact on parental anxiety and depression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional questionnaire survey was conducted on pediatric patients with AD in Shanghai, China. The questionnaires were completed by the parents of patients attending the Department of Dermatology at Shanghai Children's Medical Center between January 1, 2023, and June 3, 2024. Disease severity was assessed using the Investigator's Global Assessment (IGA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 1733 parents of children with AD completed the survey. The children had a mean age of 4.5 years (95% confidence interval: 4.4–4.7), and 54.00% were male. A history of cow's milk or egg white allergy, family history of atopic diseases, living near a street, and the absence of household pets were significantly associated with increased AD severity. Higher IGA scores were significantly associated with more severe itching and sleep disturbance, as well as elevated parental Hospital Anxiety and Depression Scale (HADS) scores, including both the anxiety and depression subscales.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Both genetic predisposition and environmental exposures were associated with increased AD severity in children. Greater disease severity was associated with higher parental psychological burden, highlighting the importance of family-centered management strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":"64 S2","pages":"13-22"},"PeriodicalIF":3.2,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145767990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms and Repair of Skin Barrier Dysfunction: The TLC Strategy","authors":"Zhenfeng Liu,&nbsp;Xiaoyi Qin,&nbsp;Xuan Wang,&nbsp;Junfen Zhang,&nbsp;Bin Yang","doi":"10.1111/ijd.70081","DOIUrl":"10.1111/ijd.70081","url":null,"abstract":"<div>\u0000 \u0000 <p>The skin barrier functions as a key line of defense with physical, chemical, microbial, and immunological components that act synergistically to protect the body against extrinsic antigens, microbes, and ultraviolet rays and prevent loss of nutrients and moisture from the body. Skin barrier dysfunction is caused by various factors, including environmental stressors, genetic predisposition, psychological stress, and inadequate nutrition. These factors can lead to metabolic, immunological, and microbial disorders of the skin barrier, which are associated with skin diseases, such as sensitive skin, rosacea, atopic dermatitis, and psoriasis, and can significantly diminish quality of life. Significant progress has been made in the development of strategies to repair skin barrier dysfunctions. In this review, we propose a repair strategy based on the “TLC” concept: “target skin disruption, lock in moisture, and connect skin cells.” Targeting skin disruption involves the implementation of interventions for skin barrier disorders, including ceramide supplementation, pH regulation, and optimized immunomodulation, to restore the metabolic, immunological, and microbial balance of the skin. Locking in moisture involves promoting moisturization and moisture retention to enhance skin hydration by reducing water loss and promoting water absorption and transport. Connecting skin cells involves the restoration of intercellular connections and the lipid bilayer structure of the stratum corneum, thereby enhancing epidermal connectivity and reinforcing the skin barrier. This multilevel strategy offers new avenues for mitigating skin barrier dysfunctions and related diseases and is of great significance in clinical applications.</p>\u0000 </div>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":"64 S2","pages":"23-32"},"PeriodicalIF":3.2,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145767936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics and Serum CGRP Level Differences Between Neurogenic Rosacea and Non-Neurogenic Rosacea","authors":"Chenchen Wu,&nbsp;Kaoyuan Zhang,&nbsp;Yang Guo,&nbsp;Chao Chen,&nbsp;Yan Liao,&nbsp;Xiaoming Liu,&nbsp;Zhuoxuan Chen,&nbsp;Lulu Yu,&nbsp;Bo Yu,&nbsp;Xiaofan Chen,&nbsp;Lin Wu","doi":"10.1111/ijd.70071","DOIUrl":"https://doi.org/10.1111/ijd.70071","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>There are limited reports on neurogenic rosacea (NR), and further clarifications are needed regarding its clinical manifestations, serological indicators, and treatment response.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Our aim was to explore the clinical features and potential serological biomarkers of NR.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We collected and analyzed the clinical characteristics, triggers, psychological burden, and treatment of 251 rosacea patients. According to the 2017 International Diagnostic Criteria for Rosacea, key clinical symptoms, and response to conventional treatment, the cohort was divided into 32 NR patients and 219 non-neurogenic rosacea (NNR) patients. Serum neuropeptide levels were detected in 20 NR patients and 20 matched NNR controls. Clinical characteristics, serum neuropeptide differences, and correlations were assessed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>NR patients exhibited more severe and more frequent flushing. Besides, neuroinflammatory-related symptoms, such as burning, occur more frequently in NR patients. The serum calcitonin gene-related peptide (CGRP) levels were significantly elevated in NR patients and correlated with clinical severity, flushing severity of rosacea, and treatment outcome.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>NR patients experienced more severe flushing and other neuroinflammatory-related symptoms. The increased serum CGRP level was positively correlated with the severity of NR, suggesting its potential as an adjunct biomarker to screen for NR in rosacea patients and guide treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":"64 S2","pages":"42-51"},"PeriodicalIF":3.2,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145766390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin Barrier Dysfunction in China: Introduction to the Special Issue","authors":"Bin Yang","doi":"10.1111/ijd.70158","DOIUrl":"10.1111/ijd.70158","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":"64 S2","pages":"3-4"},"PeriodicalIF":3.2,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145767998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of Atopic Dermatitis in China and Its Provinces, 1990–2021: A Global Burden of Disease 2021 Analysis","authors":"Weijia Zhao,&nbsp;Pengpeng Ye,&nbsp;Haihui Yang,&nbsp;Yunqing Yang,&nbsp;Shunmin Zhu,&nbsp;Hajanirina Jade Cheung,&nbsp;Bin Yang,&nbsp;Yunsheng Liang,&nbsp;Changchang Li","doi":"10.1111/ijd.70085","DOIUrl":"https://doi.org/10.1111/ijd.70085","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Atopic dermatitis (AD) has a high disease burden worldwide. However, the specific impact and geographical variations of AD in China remain unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using Global Burden of Disease (GBD) 2021 data, we assessed the AD burden (incidence, prevalence, and years lived with disability [YLDs]) across China's 33 provinces (1990–2021). Joinpoint regression analysis was used to identify temporal trends. We examined how urbanization and the human development index (HDI) influence the AD burden.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In 2021, China had 2.17 million (95% uncertainty interval [UI]: 2.08–2.26) new AD cases, 15.42 million (95% UI: 14.84–16.00) patients, and 0.68 million (95% UI: 0.35–1.14 million) YLDs. The crude incidence, prevalence, and YLD rates peaked in female individuals aged &lt; 5 years of age and showed a decreasing gradient from South to North and West to East. Overall, all three rates slightly decrease from 1990 to 2021. Heterogeneity of time trends was observed across age groups, with rapid growth in patients aged &lt; 5 years. Both the speed of urbanization and HDI were positively correlated with the incidence (<i>r</i>_urban = 0.52, <i>r</i>_HDI = 0.48), prevalence (<i>r</i>_urban = 0.50, <i>r</i>_HDI = 0.50), and YLD rates (<i>r</i>_urban = 0.61, <i>r</i>_HDI = 0.62) of average annual percentage change in people aged &lt; 5 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The disease burden due to AD is high in China, with a sharp increase in people aged &lt; 5 years. Rapid urbanization may intensify this increase, making it crucial to develop comprehensive AD management strategies that account for urbanization.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":"64 S2","pages":"5-12"},"PeriodicalIF":3.2,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145766332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moisturizer Based on Multi-Targeted Skin Barrier Repair Conception: Evidence From In Vitro and Clinical Evaluations","authors":"Bohan Xu,&nbsp;Yinjuan Wang,&nbsp;Jie Ren","doi":"10.1111/ijd.70114","DOIUrl":"10.1111/ijd.70114","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Skin barrier dysfunction is a key driver of skin sensitivity and inflammatory dermatoses. However, the long-term efficacy of existing moisturizers remains limited. This study aimed to evaluate the efficacy of a moisturizer formulated with target skin disruption, lock in moisture, connect skin cells (TLC) technology using in vitro and clinical evaluations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The efficacy of the TLC complex was assessed through ultraviolet A (UVA)–induced full-thickness skin, sodium lauryl sulfate (SLS)–damaged epidermis, and capsaicin-stimulated keratinocytes in vitro. Clinical evaluations were conducted to comprehensively assess the soothing effects, hydration enhancement, and barrier repair of the TLC technology–based moisturizer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The TLC complex significantly suppressed the expression of nuclear factor kappa B, transient receptor potential vanilloid 1, interleukin-1α, prostaglandin E2, and vascular endothelial growth factor (all <i>p</i> &lt; 0.01). It also markedly increased aquaporin-3, natural moisturizing factor levels, and the ceramide-to-protein ratio (all <i>p</i> &lt; 0.01). The expression of key barrier proteins, including filaggrin, loricrin, involucrin, keratin 10, corneodesmosin, claudin-1, and laminin-5, was significantly restored (all <i>p</i> &lt; 0.01). Clinically, the TLC moisturizer significantly reduced facial redness proportion, <i>a</i>* value, erythema index, and Sensitive Scale-10 score (all <i>p</i> &lt; 0.001). A single application markedly boosted hydration and reduced transepidermal water loss (<i>p</i> &lt; 0.001). The moisturizer also significantly accelerated barrier repair in SLS-damaged skin (<i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The TLC-based moisturizer demonstrated comprehensive anti-inflammatory, hydrating, and barrier-restoring effects in preclinical and clinical evaluations, supporting its use as a safe and effective adjuvant therapy for individuals with sensitive or compromised skin.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":"64 S2","pages":"33-41"},"PeriodicalIF":3.2,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145767951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}