First detection and biological characterization of an avian metaavulavirus 8 isolated from a migratory swan goose in Qinghai Lake, Northwest China.

IF 1.9 4区 医学 Q4 IMMUNOLOGY Microbiology and Immunology Pub Date : 2024-10-03 DOI:10.1111/1348-0421.13175
Sijie Wang, Xinxin Liu, Jianjun Chen, Weiwen Yan, Hongjin Li, Weiwei Chi, Rui Luo, Xianwen Lin, Yue Yin, Chuanrong Dong, Huihui Wang, Bowen Zheng, Hongli Li, Yifei Liu, Tobias Stoeger, Abdul Wajid, Aleksandar Dodovski, Chao Gao, Claro N Mingala, Dmitry B Andreychuk, Renfu Yin
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Abstract

Avian metaavulavirus 8 (AMAV-8), formerly known as avian paramyxovirus 8 (APMV-8), has been detected sporadically in wild birds worldwide since it was first identified in a Canadian goose in 1976. However, the presence of AMAV-8 in birds has never been reported in China. To understand the epidemiological situation of AMAV-8 and its ability to infect chickens, we conducted a surveillance study and in vivo analysis of the AMAV-8 isolate identified in total of 14,909 clinical samples collected from wild and domestic birds from 2014 to 2022 in China. However, in 2017, only one AMAV-8 virus (Y7) was successful isolated from the fresh droppings of a migratory swan goose in Qinghai Lake in Northwest China. Thereafter, we report the complete genome sequence of the Y7 strain with a genome length of 15,342 nucleotides and the Y7 isolate was genetically closely-related to wild bird-origin AMAV-8 viruses previously circulated in the United States, Japan, and Kazakhstan. Furthermore, AMAV-8 infections of one-day-old specific pathogen-free (SPF) chicks did not induce any clinical signs over the entire observation period but was associated with viral shedding for up to 8 days. Interestingly, although all birds infected with the Y7 strain seroconverted within the first week of infection, virus replication was only detected in the trachea but not in other tissues such as the brain, lung, or heart. Here, we report the complete genome, genetic and biological characterization, replication and pathogenicity analysis in vivo and first detection of AMAV-8 in China.

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首次从中国西北地区青海湖迁徙天鹅中分离出禽类元病毒 8,并对其进行生物学鉴定。
禽副黏液病毒 8 (AMAV-8),原名禽副黏液病毒 8 (APMV-8),自 1976 年首次在加拿大的一只鹅身上发现以来,已在世界各地的野生鸟类中零星发现。然而,中国从未有过禽类感染 AMAV-8 的报道。为了解AMAV-8的流行病学情况及其感染鸡的能力,我们开展了一项监测研究,并对2014年至2022年期间从中国野禽和家禽采集的共计14909份临床样本中鉴定出的AMAV-8分离株进行了体内分析。然而,2017 年,仅从中国西北部青海湖一只候鸟天鹅的新鲜粪便中成功分离出一种 AMAV-8 病毒(Y7)。此后,我们报告了Y7株的完整基因组序列,其基因组长度为15342个核苷酸,Y7分离株与之前在美国、日本和哈萨克斯坦流行的野鸟源AMAV-8病毒在基因上密切相关。此外,一天龄无特定病原体(SPF)雏鸡感染 AMAV-8 病毒后,在整个观察期间不会出现任何临床症状,但病毒脱落时间长达 8 天。有趣的是,虽然所有感染 Y7 株的雏鸡在感染后第一周内都发生了血清转换,但病毒复制只在气管中被检测到,而在其他组织(如脑、肺或心脏)中未被检测到。在此,我们报告了AMAV-8的完整基因组、遗传和生物学特征、体内复制和致病性分析,以及在中国的首次检测。
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来源期刊
Microbiology and Immunology
Microbiology and Immunology 医学-免疫学
CiteScore
5.20
自引率
3.80%
发文量
78
审稿时长
1 months
期刊介绍: Microbiology and Immunology is published in association with Japanese Society for Bacteriology, Japanese Society for Virology, and Japanese Society for Host Defense Research. It is peer-reviewed publication that provides insight into the study of microbes and the host immune, biological and physiological responses. Fields covered by Microbiology and Immunology include:Bacteriology|Virology|Immunology|pathogenic infections in human, animals and plants|pathogenicity and virulence factors such as microbial toxins and cell-surface components|factors involved in host defense, inflammation, development of vaccines|antimicrobial agents and drug resistance of microbes|genomics and proteomics.
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