{"title":"A new isocoumarin from sponge endophytic fungus <i>Aspergillus ochraceopetaliformis</i> with cytotoxic activity.","authors":"Ruitong Zhong, Chuanling Shi, Xiaoyun Wu, Yiting Zou, Jun Li, Yongqian Liang","doi":"10.1080/14786419.2024.2411373","DOIUrl":null,"url":null,"abstract":"<p><p>A new isocoumarin, 8-hydroxy-3-methyliscoumarin-6-yl acetate (<b>1</b>), was isolated together with five known compounds from sponge endophytic fungus <i>Aspergillus ochraceopetaliformis.</i> The structure of the new compound was established based on 1D and 2D NMR spectral analysis. Compounds <b>1-6</b> were evaluated for their cytotoxic activities and antimicrobial activities. Compounds <b>1</b> and <b>6</b> display cytotoxic activities against mouse melanoma cells B16 with IC<sub>50</sub> values 72.5 ± 2.6 and 1.0 ± 0.5 <i>µ</i>M, respectively. Compounds <b>4</b> and <b>5</b> displayed faint antimicrobial activities of <i>Bacillus subtilis</i>, <i>Micrococcus luteus</i> and <i>Staphylococcus aureus</i>.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2024.2411373","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
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Abstract
A new isocoumarin, 8-hydroxy-3-methyliscoumarin-6-yl acetate (1), was isolated together with five known compounds from sponge endophytic fungus Aspergillus ochraceopetaliformis. The structure of the new compound was established based on 1D and 2D NMR spectral analysis. Compounds 1-6 were evaluated for their cytotoxic activities and antimicrobial activities. Compounds 1 and 6 display cytotoxic activities against mouse melanoma cells B16 with IC50 values 72.5 ± 2.6 and 1.0 ± 0.5 µM, respectively. Compounds 4 and 5 displayed faint antimicrobial activities of Bacillus subtilis, Micrococcus luteus and Staphylococcus aureus.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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