Hongmin Xia, Xiao-Lei Du, Hong-Xiang Lou, Ping Wang
{"title":"A pair of enantiotropic carbazole alkaloids from the stems of <i>Clausena emarginata</i> C. C. Huang.","authors":"Hongmin Xia, Xiao-Lei Du, Hong-Xiang Lou, Ping Wang","doi":"10.1080/14786419.2024.2410420","DOIUrl":null,"url":null,"abstract":"<p><p>Two new carbazole alkaloids clauemarazole H (<b>1</b>) and clauemarazole I (<b>2</b>) were isolated from the stems of <i>Clausena emarginata</i> C. C. Huang. Their structures were confirmed by comprehensive spectroscopic analyses, and the absolute configurations were determined based on ECD experiments. The two compounds were evaluated for their neuroprotective effects against rotenone-induced damage in PC12 cells but did not exhibit any significant activity.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2024.2410420","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Two new carbazole alkaloids clauemarazole H (1) and clauemarazole I (2) were isolated from the stems of Clausena emarginata C. C. Huang. Their structures were confirmed by comprehensive spectroscopic analyses, and the absolute configurations were determined based on ECD experiments. The two compounds were evaluated for their neuroprotective effects against rotenone-induced damage in PC12 cells but did not exhibit any significant activity.
从Clausena emarginata C. C. Huang的茎中分离出两种新的咔唑生物碱clauemarazole H (1)和clauemarazole I (2)。通过综合光谱分析确认了它们的结构，并根据 ECD 实验确定了绝对构型。评估了这两种化合物对 PC12 细胞中由鱼藤酮诱导的神经损伤的保护作用，但未显示出任何显著的活性。
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
