{"title":"Antioxidant, antibacterial and antibiofilm activities of <i>Pittosporum napaulense</i> (DC.) against drug-resistant <i>Staphylococcus aureus</i> and <i>Shigella</i> sp.","authors":"Sajna Sameekshya Hota, Dibya Ranjan Sahoo, Subhaswaraj Pattnaik, Monika Mishra, Tapasa Mishra, Tanuja Sahu, Baishali Basundhara Naik, Malayamarutham Kalyankumarraju, Amit Kumar Dixit, Deepak Lamba, Sanjaya Kumar Y R, Rabinarayan Acharya, Pradeep Kumar Naik","doi":"10.1080/14786419.2024.2410422","DOIUrl":null,"url":null,"abstract":"<p><p>Gandhamardan has a rich heritage of floristic diversity with undocumented medicinal plants, called Anukta Dravya having immense pharmacological values. Among them, <i>Pittosporum napaulense</i> (DC.) Rehder & E. H. Wilson is an important medicinal plant with widespread pharmacological importance. The antioxidant potential, antibacterial and antibiofilm activities of <i>P. napaulense</i> (DC.) were evaluated. The ethanolic extract showed the highest share of phenolic and flavonoid contents responsible for DPPH and ABTS radical scavenging activity with an IC50 of 5.58 and 5.28 µg/ml, respectively. In addition, the extracts also showed antibacterial and antibiofilm properties against multidrug-resistant bacterial strains, <i>Staphylococcus aureus</i> and <i>Shigella</i> sp. The biological activities of <i>P. napaulense</i> (DC.) bark could be attributed to the presence of phytoconstituents such as Malabaricone C, Borapetoside B, Kanzonol R. as evident from UPLC-Q-TOF-MS analysis. Based on the bioactivities; this plant could be explored for the development of potential therapeutic drug candidates against severe bacterial diseases.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2024.2410422","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Gandhamardan has a rich heritage of floristic diversity with undocumented medicinal plants, called Anukta Dravya having immense pharmacological values. Among them, Pittosporum napaulense (DC.) Rehder & E. H. Wilson is an important medicinal plant with widespread pharmacological importance. The antioxidant potential, antibacterial and antibiofilm activities of P. napaulense (DC.) were evaluated. The ethanolic extract showed the highest share of phenolic and flavonoid contents responsible for DPPH and ABTS radical scavenging activity with an IC50 of 5.58 and 5.28 µg/ml, respectively. In addition, the extracts also showed antibacterial and antibiofilm properties against multidrug-resistant bacterial strains, Staphylococcus aureus and Shigella sp. The biological activities of P. napaulense (DC.) bark could be attributed to the presence of phytoconstituents such as Malabaricone C, Borapetoside B, Kanzonol R. as evident from UPLC-Q-TOF-MS analysis. Based on the bioactivities; this plant could be explored for the development of potential therapeutic drug candidates against severe bacterial diseases.
期刊介绍:
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.