Examining relationships among NODDI indices of white matter structure in prefrontal cortical-thalamic-striatal circuitry and OCD symptomatology.

IF 5.8 1区医学 Q1 PSYCHIATRY Translational Psychiatry Pub Date : 2024-10-02 DOI:10.1038/s41398-024-03101-9

João Paulo Lima Santos, Amelia Versace, Manan Arora, Michele A Bertocci, Henry W Chase, Alex Skeba, Simona Graur, Lisa Bonar, Chiara Maffei, Anastasia Yendiki, Steven A Rasmussen, Suzanne N Haber, Mary L Phillips

{"title":"Examining relationships among NODDI indices of white matter structure in prefrontal cortical-thalamic-striatal circuitry and OCD symptomatology.","authors":"João Paulo Lima Santos, Amelia Versace, Manan Arora, Michele A Bertocci, Henry W Chase, Alex Skeba, Simona Graur, Lisa Bonar, Chiara Maffei, Anastasia Yendiki, Steven A Rasmussen, Suzanne N Haber, Mary L Phillips","doi":"10.1038/s41398-024-03101-9","DOIUrl":null,"url":null,"abstract":"<p><p>Obsessive-compulsive disorder is a psychiatric disorder characterized by intrusive thoughts and repetitive behaviors. There are two prominent features: Harm Avoidance (HA) and Incompleteness (INC). Previous resting-state studies reported abnormally elevated connectivity between prefrontal cortical (PFC) and subcortical regions (thalamus, striatum) in OCD participants. Yet, little is known about the white matter (WM) structural abnormalities in these connections. Using brain parcellation and segmentation, whole brain tractography, and Neurite Orientation Dispersion and Density Imaging (NODDI), we aimed to characterize WM structural abnormalities in OCD vs. healthy controls and determine the extent to which NODDI indices of these connections were associated with subthreshold-threshold HA, INC and overall OCD symptom severity across all participants. Four PFC regions were segmented: ventral medial (vmPFC), ventrolateral (vlPFC), dorsomedial (dmPFC), and dorsolateral (dlPFC). NODDI Neurite Density (NDI) and Orientation Dispersion (ODI) indices of WM structure were extracted from connections between these PFC regions and the thalamus (42 OCD, 44 healthy controls, mean age[SD] = 23.65[4.25]y, 63.9% female) and striatum (38 OCD, 41 healthy controls, mean age[SD] = 23.59[4.27]y, 64.5% female). Multivariate analyses of covariance revealed no between-group differences in these indices. Multivariate regression models revealed that greater NDI in vmPFC-thalamus, greater NDI and ODI in vmPFC-striatum, and greater NDI in dmPFC-thalamus connections were associated with greater INC severity (Q ≤ 0.032). These findings highlight the utility of NODDI in the examination of WM structure in OCD, provide valuable insights into specific WM alterations underlying dimensional INC, and can facilitate the development of customized treatments for OCD individuals with treatment-resistant symptoms.</p>","PeriodicalId":23278,"journal":{"name":"Translational Psychiatry","volume":null,"pages":null},"PeriodicalIF":5.8000,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447092/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translational Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41398-024-03101-9","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

Abstract

Obsessive-compulsive disorder is a psychiatric disorder characterized by intrusive thoughts and repetitive behaviors. There are two prominent features: Harm Avoidance (HA) and Incompleteness (INC). Previous resting-state studies reported abnormally elevated connectivity between prefrontal cortical (PFC) and subcortical regions (thalamus, striatum) in OCD participants. Yet, little is known about the white matter (WM) structural abnormalities in these connections. Using brain parcellation and segmentation, whole brain tractography, and Neurite Orientation Dispersion and Density Imaging (NODDI), we aimed to characterize WM structural abnormalities in OCD vs. healthy controls and determine the extent to which NODDI indices of these connections were associated with subthreshold-threshold HA, INC and overall OCD symptom severity across all participants. Four PFC regions were segmented: ventral medial (vmPFC), ventrolateral (vlPFC), dorsomedial (dmPFC), and dorsolateral (dlPFC). NODDI Neurite Density (NDI) and Orientation Dispersion (ODI) indices of WM structure were extracted from connections between these PFC regions and the thalamus (42 OCD, 44 healthy controls, mean age[SD] = 23.65[4.25]y, 63.9% female) and striatum (38 OCD, 41 healthy controls, mean age[SD] = 23.59[4.27]y, 64.5% female). Multivariate analyses of covariance revealed no between-group differences in these indices. Multivariate regression models revealed that greater NDI in vmPFC-thalamus, greater NDI and ODI in vmPFC-striatum, and greater NDI in dmPFC-thalamus connections were associated with greater INC severity (Q ≤ 0.032). These findings highlight the utility of NODDI in the examination of WM structure in OCD, provide valuable insights into specific WM alterations underlying dimensional INC, and can facilitate the development of customized treatments for OCD individuals with treatment-resistant symptoms.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

研究前额叶皮质-丘脑-纹状体回路白质结构的 NODDI 指数与强迫症症状之间的关系。

强迫症是一种以侵入性思维和重复行为为特征的精神障碍。它有两个显著特征：伤害回避（HA）和不完整性（INC）。之前的静息态研究报告称，强迫症患者的前额叶皮质（PFC）和皮质下区域（丘脑、纹状体）之间的连接异常升高。然而，人们对这些连接中的白质（WM）结构异常却知之甚少。我们利用脑分割和分块、全脑束成像和神经元定向弥散和密度成像（NODDI）技术，旨在描述强迫症患者与健康对照组患者的白质结构异常，并确定这些连接的 NODDI 指数与所有参与者的阈下 HA、INC 和总体强迫症症状严重程度的相关程度。对四个 PFC 区域进行了分割：腹内侧 (vmPFC)、腹外侧 (vlPFC)、背内侧 (dmPFC) 和背外侧 (dlPFC)。从这些PFC区域与丘脑（42名强迫症患者，44名健康对照者，平均年龄[SD]=23.65[4.25]岁，女性占63.9%）和纹状体（38名强迫症患者，41名健康对照者，平均年龄[SD]=23.59[4.27]岁，女性占64.5%）之间的连接中提取了WM结构的NODDI神经元密度（NDI）和定向分散（ODI）指数。多变量协方差分析表明，这些指数没有组间差异。多变量回归模型显示，vmPFC-丘脑中更大的NDI、vmPFC-纹状体中更大的NDI和ODI以及dmPFC-丘脑连接中更大的NDI与更严重的INC相关（Q≤0.032）。这些发现凸显了NODDI在检查强迫症患者WM结构中的作用，为了解维度INC背后的特定WM改变提供了宝贵的见解，并有助于为具有耐药性症状的强迫症患者开发定制化治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Translational Psychiatry PSYCHIATRY-

CiteScore

11.50

自引率

2.90%

发文量

484

审稿时长

23 weeks

期刊介绍： Psychiatry has suffered tremendously by the limited translational pipeline. Nobel laureate Julius Axelrod''s discovery in 1961 of monoamine reuptake by pre-synaptic neurons still forms the basis of contemporary antidepressant treatment. There is a grievous gap between the explosion of knowledge in neuroscience and conceptually novel treatments for our patients. Translational Psychiatry bridges this gap by fostering and highlighting the pathway from discovery to clinical applications, healthcare and global health. We view translation broadly as the full spectrum of work that marks the pathway from discovery to global health, inclusive. The steps of translation that are within the scope of Translational Psychiatry include (i) fundamental discovery, (ii) bench to bedside, (iii) bedside to clinical applications (clinical trials), (iv) translation to policy and health care guidelines, (v) assessment of health policy and usage, and (vi) global health. All areas of medical research, including — but not restricted to — molecular biology, genetics, pharmacology, imaging and epidemiology are welcome as they contribute to enhance the field of translational psychiatry.