A cross-sectional study of non-suicidal self-injury in adults with depressive disorder: Associations with inflammation and cardiac structure and function

IF 3.5 2区 医学 Q2 PSYCHIATRY Journal of Psychosomatic Research Pub Date : 2024-09-28 DOI:10.1016/j.jpsychores.2024.111944
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Abstract

Objective

Non-suicidal self-injury (NSSI) is associated with cardiovascular disease (CVD), whereas inflammation is associated with both CVD and NSSI. However, few studies have investigated the correlation among NSSI, inflammation, and cardiac structure and function in CVD-free adult patients with depressive disorders.

Methods

We recruited 88 CVD-free adult patients with depressive disorders and 37 healthy individuals. Patients were divided into NSSI (n = 21) and non-NSSI (n = 67) groups based on the presence or absence of NSSI. Healthy individuals comprised the controls (n = 37). Echocardiography was applied to assess cardiac structure and function, and C-reactive protein (CRP) levels were measured to indicate inflammation.

Results

Compared with controls, the NSSI group exhibited a larger left ventricular end-systolic diameter (LVESD) and smaller left ventricular ejection fraction (LVEF). Left ventricular end-systolic volume (LVESV) was larger in the NSSI group than in the non-NSSI group. The CRP levels were higher in the NSSI group than in the non-NSSI group; however, this difference was not statistically significant. NSSI was positively associated with LVESD (β = 1.928, p = 0.006) and LVESV (β = 5.368, p = 0.003), negatively correlated with LVEF (β = −2.600, p = 0.029), and positively correlated with CRP levels (β = 0.116, p = 0.004). CRP levels did not mediate the association between NSSI and cardiac structure and function.

Conclusions

This study indicated that NSSI was associated with left ventricular structure, systolic function, and inflammation, but CRP did not mediate the relationship between NSSI and echocardiogram parameters.
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抑郁症成人非自杀性自伤横断面研究:与炎症及心脏结构和功能的关系
目的:非自杀性自伤(NSSI)与心血管疾病(CVD)有关,而炎症与心血管疾病和非自杀性自伤都有关。然而,很少有研究调查无心血管疾病的成年抑郁症患者的 NSSI、炎症、心脏结构和功能之间的相关性:我们招募了 88 名无心血管疾病的成年抑郁症患者和 37 名健康人。根据有无NSSI将患者分为NSSI组(21人)和非NSSI组(67人)。健康人为对照组(37 人)。超声心动图用于评估心脏结构和功能,C反应蛋白(CRP)水平的测量用于显示炎症情况:结果:与对照组相比,NSSI 组的左心室收缩末期直径(LVESD)较大,左心室射血分数(LVEF)较小。NSSI组的左心室收缩末期容积(LVESV)大于非NSSI组。NSSI 组的 CRP 水平高于非 NSSI 组,但差异无统计学意义。NSSI 与 LVESD(β = 1.928,p = 0.006)和 LVESV(β = 5.368,p = 0.003)呈正相关,与 LVEF 呈负相关(β = -2.600,p = 0.029),与 CRP 水平呈正相关(β = 0.116,p = 0.004)。CRP水平并不介导NSSI与心脏结构和功能之间的关联:本研究表明,NSSI 与左心室结构、收缩功能和炎症有关,但 CRP 并不介导 NSSI 与超声心动图参数之间的关系。
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来源期刊
Journal of Psychosomatic Research
Journal of Psychosomatic Research 医学-精神病学
CiteScore
7.40
自引率
6.40%
发文量
314
审稿时长
6.2 weeks
期刊介绍: The Journal of Psychosomatic Research is a multidisciplinary research journal covering all aspects of the relationships between psychology and medicine. The scope is broad and ranges from basic human biological and psychological research to evaluations of treatment and services. Papers will normally be concerned with illness or patients rather than studies of healthy populations. Studies concerning special populations, such as the elderly and children and adolescents, are welcome. In addition to peer-reviewed original papers, the journal publishes editorials, reviews, and other papers related to the journal''s aims.
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