Meghna Rajaprakash, Meredith Palmore, Kelly M Bakulski, Ellen Howerton, Kristen Lyall, Rebecca J Schmidt, Craig Newschaffer, Lisa A Croen, Irva Hertz-Picciotto, Heather Volk, Christine Ladd-Acosta, M Daniele Fallin
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引用次数: 0
Abstract
Background: Socioeconomic position (SEP), which reflects one's position in society and access to resources, is strongly tied to neurodevelopment and is associated with epigenetic changes.
Aim: This study examined whether DNA methylation signatures of prenatal SEP, measured in birth samples, are associated with child neurodevelopmental outcomes at 36 months of age.
Methods: Prenatal SEP DNA methylation scores were derived using 97 placenta and 127 cord blood biospecimens in the Early Autism Risk Longitudinal Investigation cohort. Participants completed the Mullen Scales of Early Learning (MSEL) and Vineland Adaptive Behavior Scales (VABS) at 36 months of age. Generalized regression analyses, adjusting for maternal age and race, were performed to test the association between SEP methylation score, for each birth biospecimen type, and MSEL and VABS scores.
Results: Significant associations were observed between placenta SEP methylation score and MSEL Expressive Language outcomes (beta = -2.7, p = 0.046, 95 % CI [- 5.43, -0.05]) and Receptive Language outcomes (beta = -2.5, p = 0.037, 95 % CI [-4.82, -0.16]). In cord blood, methylation-SEP scores were significantly associated with Receptive Language outcomes (beta = -2.0, p = 0.037, 95 % CI [-3.85, -0.12]). No significant associations were observed with VABS scores.
Conclusion: Our results confirm associations between prenatal SEP and early childhood language development using a novel empiric DNA methylation measure of exposure.
期刊介绍:
Research In Developmental Disabilities is aimed at publishing original research of an interdisciplinary nature that has a direct bearing on the remediation of problems associated with developmental disabilities. Manuscripts will be solicited throughout the world. Articles will be primarily empirical studies, although an occasional position paper or review will be accepted. The aim of the journal will be to publish articles on all aspects of research with the developmentally disabled, with any methodologically sound approach being acceptable.