Juntao Yang, Miaomiao Tian, Junbiao Chang, Bingxian Liu
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引用次数: 0
Abstract
The efficient preparation of long-chain amines via a one-step transfer-hydrogenation/reductive-amination reaction (THRA) of polyenals has been achieved. This strategy, which combines transfer hydrogenation and reductive amination, significantly enhances the synthetic efficiency of amino compounds. Additionally, this protocol offers a practical method for carbon-chain elongation/amination to construct long-chain amino compounds. The reaction system exhibits remarkable versatility in substrate scope using a non-noble ruthenium catalyst with formate and isopropanol as hydrogen sources, making it an appealing method for drug synthesis and molecular modification.
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