Muhammad Asif Javaid, Yousef M Alanazi, De-Qiang Li, Yumei Gong, Mohanad El-Harbawi, Saliha Ahmad, Usama Tahir, Inam Ullah, Muhammad Tahir Hussain, Hina Iqbal
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引用次数: 0
Abstract
For the first time in this research, using a mixture design approach, polyurethanes (PUs) based on chitosan (CSN) and carboxymethyl cellulose (CMC) were synthesized to develop a high molecular weight polymer. In the synthesis process, a reaction between isophorone diisocyanate (IPDI) and hydroxyl-terminated polybutadiene was carried out to synthesize a prepolymer containing free NCO groups at the corners. This prepolymer was further reacted with changing moles ratio of CSN and CMC following the principles of statistical mixture design. The structural confirmation of the developed PUs was carried out through spectroscopic techniques (FTIR and NMR). The molecular weights of the PU specimens were characterized using gel permeation chromatography. The findings demonstrated that the interaction between CMC and CSN led to a notable increase in the molecular weights of the samples, supported by a significant p-value of 0.006. Additionally, the analysis of variance (ANOVA) disclosed that the employed mixture design and the resulting interaction model effectively account for 98 % of the total variation observed in the molecular weights. The sample labeled as PUS-3 (CMC0.50:CSN0.50) emerged as the most significant formulation, exhibiting a noteworthy 27.9 % improvement in the polymer molecular weight compared to the base sample, denoted as PUS-1 (CMC1.00:CSN0.00).
期刊介绍:
The International Journal of Biological Macromolecules is a well-established international journal dedicated to research on the chemical and biological aspects of natural macromolecules. Focusing on proteins, macromolecular carbohydrates, glycoproteins, proteoglycans, lignins, biological poly-acids, and nucleic acids, the journal presents the latest findings in molecular structure, properties, biological activities, interactions, modifications, and functional properties. Papers must offer new and novel insights, encompassing related model systems, structural conformational studies, theoretical developments, and analytical techniques. Each paper is required to primarily focus on at least one named biological macromolecule, reflected in the title, abstract, and text.