Biotransformation and oxidative stress markers in yellowfin seabream (Acanthopagrus latus): Interactive impacts of microplastics and florfenicol.

IF 8.2 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Science of the Total Environment Pub Date : 2024-12-01 Epub Date: 2024-10-01 DOI:10.1016/j.scitotenv.2024.176661

Mehrnaz Shirmohammadi, Farahnaz Kianersi, Nima Shiry, Mario Alberto Burgos-Aceves, Caterina Faggio

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Abstract

This study investigates the combined toxicity of microplastics (MPs) and florfenicol (FLO) on biotransformation enzymes and oxidative stress biomarkers in the liver and kidney of yellowfin seabream (Acanthopagrus latus). Fish were fed 15 mg kg^-1 of FLO and 100 or 500 mg kg^-1 of MPs for 10 days. Biomarkers, including ethoxyresorufin-O-deethylase, glutathione-S-transferase, superoxide dismutase, catalase, glutathione peroxidase, malondialdehyde (MDA), and protein carbonylation (PC), were measured in both organs at 1, 7, and 14 days post-exposure. FLO levels peaked on day 1 and declined after that. Liver biomarkers were more responsive to pollutants, with the combined exposure of FLO and MPs leading to more pronounced toxicity. By day 14, only the FLO group showed a return to baseline biomarker levels, while MDA and PC levels remained elevated in MPs and co-exposed groups. These findings highlight the importance of considering the interactive effects of multiple pollutants in addressing marine environmental stressors.

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黄鳍鲷的生物转化和氧化应激标记：微塑料和氟苯尼考的交互影响。

本研究调查了微塑料（MPs）和氟苯尼考（FLO）对黄鳍鲷（Acanthopagrus latus）肝脏和肾脏中生物转化酶和氧化应激生物标志物的联合毒性。连续 10 天给鱼喂食 15 毫克/千克的 FLO 和 100 或 500 毫克/千克的 MPs。在暴露后 1、7 和 14 天测量两个器官中的生物标志物，包括乙氧基脱乙基苏木素酶、谷胱甘肽-S-转移酶、超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶、丙二醛 (MDA) 和蛋白质羰基化 (PC)。FLO 水平在第 1 天达到峰值，之后开始下降。肝脏生物标志物对污染物的反应更为敏感，同时暴露于 FLO 和 MPs 会导致更明显的毒性。到第 14 天，只有 FLO 组的生物标志物水平恢复到基线水平，而 MPs 组和共同暴露组的 MDA 和 PC 水平仍然升高。这些发现凸显了在应对海洋环境胁迫时考虑多种污染物交互影响的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science of the Total Environment 环境科学-环境科学

CiteScore

17.60

自引率

10.20%

发文量

8726

审稿时长

2.4 months

期刊介绍： The Science of the Total Environment is an international journal dedicated to scientific research on the environment and its interaction with humanity. It covers a wide range of disciplines and seeks to publish innovative, hypothesis-driven, and impactful research that explores the entire environment, including the atmosphere, lithosphere, hydrosphere, biosphere, and anthroposphere. The journal's updated Aims & Scope emphasizes the importance of interdisciplinary environmental research with broad impact. Priority is given to studies that advance fundamental understanding and explore the interconnectedness of multiple environmental spheres. Field studies are preferred, while laboratory experiments must demonstrate significant methodological advancements or mechanistic insights with direct relevance to the environment.