Phylogenetic analysis, genetic diversity, and epidemiology of pigeon paramyxovirus type 1 in China

IF 2.5 4区医学 Q3 VIROLOGY Archives of Virology Pub Date : 2024-10-04 DOI:10.1007/s00705-024-06144-x

Chuqi Huang, Shaoyu Tu, Wei Sheng, Zhihao Wang, Zhipeng Lin, Jing Qian, Jiahui Zou, Hongbo Zhou

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Abstract

Pigeon paramyxovirus type 1 (PPMV-1) poses significant economic challenges to the pigeon industry in China. However, information about the prevalence, genetic diversity, and epidemiology of PPMV-1 in China is still lacking. In this study, we isolated six strains of PPMV-1 from Hubei and Zhejiang provinces in 2022. All six isolates were found to belong to subgenotype VI.2.1.1.2.2. Five of them were identified as mesogenic and one as lentogenic. Multiple mutations were observed in the F and HN proteins of these isolates. Comprehensive analysis of global PPMV-1 strains highlighted the dominance of genotype VI, showing that VI.2.1.1.2.2 has been the dominant subgenotype since 2011. We also identified 36 host-specific amino acid substitutions that are unique to PPMV-1 in comparison to chicken-origin NDVs. The data reported here contribute to our understanding of the epidemiology, genetic diversity, and prevalence of PPMV-1 and serve as a valuable reference for the prevention and control of PPMV-1.

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中国鸽副黏液病毒 1 型的系统发育分析、遗传多样性和流行病学。

鸽副粘病毒1型（PPMV-1）给中国养鸽业带来了巨大的经济挑战。然而，有关 PPMV-1 在中国的流行率、遗传多样性和流行病学的信息仍然缺乏。在这项研究中，我们在 2022 年从湖北和浙江两省分离出了六株 PPMV-1。这六株病毒均属于亚基因型 VI.2.1.1.2.2。其中五株被鉴定为中源型，一株为外源型。在这些分离物的 F 蛋白和 HN 蛋白中观察到多种突变。对全球 PPMV-1 株系的综合分析凸显了基因型 VI 的优势，表明 VI.2.1.1.2.2 自 2011 年以来一直是优势亚基因型。我们还发现了 36 个与鸡源 NDV 相比 PPMV-1 独有的宿主特异性氨基酸取代。本文报告的数据有助于我们了解 PPMV-1 的流行病学、遗传多样性和发病率，并为预防和控制 PPMV-1 提供了有价值的参考。

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来源期刊

Archives of Virology 医学-病毒学

CiteScore

5.10

自引率

7.40%

发文量

324

审稿时长

4.5 months

期刊介绍： Archives of Virology publishes original contributions from all branches of research on viruses, virus-like agents, and virus infections of humans, animals, plants, insects, and bacteria. Coverage spans a broad spectrum of topics, from descriptions of newly discovered viruses, to studies of virus structure, composition, and genetics, to studies of virus interactions with host cells, organisms and populations. Studies employ molecular biologic, molecular genetics, and current immunologic and epidemiologic approaches. Contents include studies on the molecular pathogenesis, pathophysiology, and genetics of virus infections in individual hosts, and studies on the molecular epidemiology of virus infections in populations. Also included are studies involving applied research such as diagnostic technology development, monoclonal antibody panel development, vaccine development, and antiviral drug development.Archives of Virology wishes to publish obituaries of recently deceased well-known virologists and leading figures in virology.