Bacteriological characteristics and changes of Streptococcus pneumoniae serotype 35B after vaccine implementation in Japan.

IF 2.5 4区 医学 Q3 INFECTIOUS DISEASES Epidemiology and Infection Pub Date : 2024-10-04 DOI:10.1017/S0950268824001031
Haruko Miyazaki, Bin Chang, Michinaga Ogawa, Rie Shibuya, Misako Takata, Shigeki Nakamura, Kimiko Ubukata, Yoshitsugu Miyazaki, Tetsuya Matsumoto, Yukihiro Akeda
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Abstract

Streptococcus pneumoniae serotype 35B, a non-vaccine type, is a major contributor to the increase in pneumococcal infection post-vaccination. We aimed to understand the mechanism of its spread by characterizing 35B. The serotype, type 1 pilus (T1P) positivity, and antimicrobial susceptibility of 319 isolates in 2018-2022 were analysed and compared with those of isolates in 2014-2017 to find the changes. 35B accounted for 40 (12.5%) isolates. T1P positivity was notably higher in 35B (87.5%) than in the other serotypes. To confirm the role of T1P, an adhesion factor, we compared adherence to A549 cells between T1P-positive 35B isolates and their T1P-deficient mutants, showing contribution of T1P to adherence. Penicillin-non-susceptible rate of 35B was 87.5%, and meropenem-resistant 35B rate was 35.0%, which increased from 14.5% of 2014-2017 (p = 0.009). Multilocus sequence typing was performed in 35B strains. Prevalence of clonal complex 558, harbouring T1P and exhibiting multidrug non-susceptibility, suggested the advantages of 35B in attachment and survival in the host. The emergence of ST156 isolates, T1P-positive and non-susceptible to β-lactams, has raised concern about expansion in Japan. The increase of serotype 35B in pneumococcal diseases might have occurred due to its predominant colonizing ability after the elimination of the vaccine-serotypes.

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日本实施疫苗接种后肺炎链球菌血清型 35B 的细菌学特征和变化。
肺炎链球菌血清型 35B 是一种非疫苗型肺炎链球菌,是疫苗接种后肺炎球菌感染增加的主要原因。我们的目的是通过描述 35B 的特征来了解其传播机制。我们分析了 2018-2022 年 319 株分离株的血清型、1 型柔毛(T1P)阳性率和抗菌药敏感性,并与 2014-2017 年分离株的血清型、1 型柔毛(T1P)阳性率和抗菌药敏感性进行了比较,以发现其中的变化。35B占40个(12.5%)分离株。35B 的 T1P 阳性率(87.5%)明显高于其他血清型。为了证实 T1P(一种粘附因子)的作用,我们比较了 T1P 阳性的 35B 分离物及其 T1P 缺失的突变体对 A549 细胞的粘附性,结果显示 T1P 对粘附性有贡献。35B的青霉素不敏感率为87.5%,美罗培南耐药率为35.0%,比2014-2017年的14.5%有所上升(p = 0.009)。对35B菌株进行了多焦点序列分型。克隆复合体 558 的流行,携带 T1P 并表现出对多种药物的不敏感性,表明 35B 在宿主的附着和存活方面具有优势。T1P 阳性且对β-内酰胺类药物无敏感性的 ST156 分离物的出现引起了人们对其在日本扩展的担忧。肺炎球菌疾病中血清型 35B 的增加可能是由于其在疫苗血清型被淘汰后的主要定植能力。
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来源期刊
Epidemiology and Infection
Epidemiology and Infection 医学-传染病学
CiteScore
4.10
自引率
2.40%
发文量
366
审稿时长
3-6 weeks
期刊介绍: Epidemiology & Infection publishes original reports and reviews on all aspects of infection in humans and animals. Particular emphasis is given to the epidemiology, prevention and control of infectious diseases. The scope covers the zoonoses, outbreaks, food hygiene, vaccine studies, statistics and the clinical, social and public-health aspects of infectious disease, as well as some tropical infections. It has become the key international periodical in which to find the latest reports on recently discovered infections and new technology. For those concerned with policy and planning for the control of infections, the papers on mathematical modelling of epidemics caused by historical, current and emergent infections are of particular value.
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