Autoimmune Retinopathy Following COVID-19: A Case Report.

IF 2.6 4区医学 Q2 OPHTHALMOLOGY Ocular Immunology and Inflammation Pub Date : 2024-10-04 DOI:10.1080/09273948.2024.2372666

Sahba Fekri, Parisa Mahmoudimehr, Behrooz Oliya, Seyed-Hossein Abtahi, Hosein Nouri

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Abstract

Purpose: To present a presumed case of non-paraneoplastic autoimmune retinopathy (nPAIR) following COVID-19 in a healthy woman.

Methods: A single case was evaluated and followed for 32 months.

Results: A healthy 32-year-old woman presented with photopsia and paracentral scotoma (OU) after a recent COVID-19 infection. Past medical history and family history were unremarkable. Her visual acuity was normal (OU). Retinal atrophy, mild disc pallor, and foveal reflex attenuation were observed (OU). Optical coherence tomography (OCT) scans showed outer nuclear layer thinning and ellipsoid zone disruption (OU). The visual field test showed blind spot enlargement and arcuate scotomas (OU). Uveitis workup and underlying malignancy investigations were negative. A diagnosis of nPAIR was presumed. At the time, she refused therapy, and 20 months later, her visual acuity was stable, but there were progressive retinal atrophic changes and visual field constriction. After initiation of glucocorticoids and immunosuppressive therapy, flashing lights completely disappeared, her visual field was stabilized without progression, and OCT scans showed partial recovery of ellipsoid zone.

Conclusion: SARS-CoV-2 infection may be a trigger for nPAIR in susceptible individuals, but further research is needed to determine this association.

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COVID-19 后的自身免疫性视网膜病变：病例报告

目的：介绍一例推测为非副肿瘤性自身免疫性视网膜病变（nPAIR）的健康女性COVID-19病例：方法：对一例病例进行评估，并随访 32 个月：结果：一名32岁的健康女性在近期感染COVID-19后出现视力下降和旁中心视网膜病变（OU）。既往病史和家族史均无异常。她的视力正常（OU）。观察到视网膜萎缩、轻度视盘苍白和眼窝反射衰减（OU）。光学相干断层扫描（OCT）显示核外层变薄，椭圆带中断（OU）。视野测试显示盲点扩大和弧形视网膜瘤（OU）。葡萄膜炎检查和潜在恶性肿瘤检查均为阴性。推测诊断为 nPAIR。20 个月后，她的视力趋于稳定，但视网膜出现进行性萎缩性改变，视野缩小。在开始使用糖皮质激素和免疫抑制剂治疗后，闪光完全消失，视野稳定，无进展，OCT扫描显示椭圆形区部分恢复：结论：在易感人群中，SARS-CoV-2 感染可能是诱发 nPAIR 的一个因素，但要确定这种关联性还需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ocular Immunology and Inflammation 医学-眼科学

CiteScore

6.20

自引率

15.20%

发文量

285

审稿时长

6-12 weeks

期刊介绍： Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.