Oxytocin differentially modulates reward system responses to social and non-social incentives.

IF 3.5 3区 医学 Q2 NEUROSCIENCES Psychopharmacology Pub Date : 2024-10-04 DOI:10.1007/s00213-024-06695-6
Matthew D Thurston, Lauren C Ericksen, Maci M Jacobson, Allison Bustamante, Vincent Koppelmans, Brian J Mickey, Tiffany M Love
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Abstract

Rationale: Oxytocin has been shown to modulate behavior related to processing of monetary incentives and to regulate social and reproductive behavior, yet little is known about how oxytocin differentially influences neural responses to social and non-social incentives.

Objectives: We aimed to evaluate the effects of oxytocin administration on behavioral and neural responses to social and monetary incentives.

Methods: Twenty-eight healthy adults (age 18-45 years) performed both monetary and social incentive tasks during blood oxygenation level dependent (BOLD) imaging. Intranasal oxytocin or placebo was administered before each scan using a double blind, randomized, cross-over design. Task performance and self-reported motivation and mood states were collected. Time-series analysis was conducted to assess the influence of oxytocin on the hemodynamic response in the ventral tegmental area and substantia nigra (VTA/SN) and nucleus accumbens (NAc).

Results: Oxytocin demonstrated a multifaceted effect on VTA/SN and NAc when processing reward incentives, with it increasing BOLD response in VTA/SN and decreasing BOLD response in NAc during social incentive anticipation. A reversal of this was shown with decreased BOLD responses in the VTA/SN and increased BOLD response in the NAc during monetary incentive anticipation.

Conclusions: Our findings suggest a more nuanced purpose of oxytocin when evaluating reward incentive decision making. It is possible that while oxytocin does increase salience to rewards, that it is more important for cognitive control when determining short-term versus long-term benefits in rewards. Future studies should more closely examine the relationship between oxytocin and delay discounting.

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催产素能以不同方式调节奖励系统对社会和非社会激励的反应。
理论依据:催产素已被证明可以调节与货币激励处理相关的行为,并调节社会和生殖行为,但人们对催产素如何不同程度地影响神经对社会和非社会激励的反应知之甚少:我们旨在评估注射催产素对社交和货币激励的行为和神经反应的影响:28名健康成年人(18-45岁)在血氧水平依赖(BOLD)成像过程中完成了货币和社交激励任务。采用双盲、随机、交叉设计,在每次扫描前鼻内注射催产素或安慰剂。研究人员收集了任务表现、自我报告的动机和情绪状态。研究人员进行了时间序列分析,以评估催产素对腹侧被盖区和黑质(VTA/SN)及伏隔核(NAc)血液动力学反应的影响:催产素在处理奖励激励时对VTA/SN和NAc有多方面的影响,在社会激励预期时,催产素会增加VTA/SN的BOLD反应,降低NAc的BOLD反应。与之相反的是,在金钱奖励预期过程中,VTA/SN的BOLD反应降低,而NAc的BOLD反应升高:我们的研究结果表明,在评估奖励激励决策时,催产素的作用更加细致入微。我们的研究结果表明,在评估奖励激励决策时,催产素的作用更加微妙。虽然催产素可能会增加奖励的显著性,但在确定奖励的短期利益和长期利益时,催产素对认知控制的作用更为重要。未来的研究应该更仔细地研究催产素与延迟折扣之间的关系。
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来源期刊
Psychopharmacology
Psychopharmacology 医学-精神病学
CiteScore
7.10
自引率
5.90%
发文量
257
审稿时长
2-4 weeks
期刊介绍: Official Journal of the European Behavioural Pharmacology Society (EBPS) Psychopharmacology is an international journal that covers the broad topic of elucidating mechanisms by which drugs affect behavior. The scope of the journal encompasses the following fields: Human Psychopharmacology: Experimental This section includes manuscripts describing the effects of drugs on mood, behavior, cognition and physiology in humans. The journal encourages submissions that involve brain imaging, genetics, neuroendocrinology, and developmental topics. Usually manuscripts in this section describe studies conducted under controlled conditions, but occasionally descriptive or observational studies are also considered. Human Psychopharmacology: Clinical and Translational This section comprises studies addressing the broad intersection of drugs and psychiatric illness. This includes not only clinical trials and studies of drug usage and metabolism, drug surveillance, and pharmacoepidemiology, but also work utilizing the entire range of clinically relevant methodologies, including neuroimaging, pharmacogenetics, cognitive science, biomarkers, and others. Work directed toward the translation of preclinical to clinical knowledge is especially encouraged. The key feature of submissions to this section is that they involve a focus on clinical aspects. Preclinical psychopharmacology: Behavioral and Neural This section considers reports on the effects of compounds with defined chemical structures on any aspect of behavior, in particular when correlated with neurochemical effects, in species other than humans. Manuscripts containing neuroscientific techniques in combination with behavior are welcome. We encourage reports of studies that provide insight into the mechanisms of drug action, at the behavioral and molecular levels. Preclinical Psychopharmacology: Translational This section considers manuscripts that enhance the confidence in a central mechanism that could be of therapeutic value for psychiatric or neurological patients, using disease-relevant preclinical models and tests, or that report on preclinical manipulations and challenges that have the potential to be translated to the clinic. Studies aiming at the refinement of preclinical models based upon clinical findings (back-translation) will also be considered. The journal particularly encourages submissions that integrate measures of target tissue exposure, activity on the molecular target and/or modulation of the targeted biochemical pathways. Preclinical Psychopharmacology: Molecular, Genetic and Epigenetic This section focuses on the molecular and cellular actions of neuropharmacological agents / drugs, and the identification / validation of drug targets affecting the CNS in health and disease. We particularly encourage studies that provide insight into the mechanisms of drug action at the molecular level. Manuscripts containing evidence for genetic or epigenetic effects on neurochemistry or behavior are welcome.
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