{"title":"Single-atom editing with light","authors":"Ellie F. Plachinski, Tehshik P. Yoon","doi":"10.1126/science.ads2595","DOIUrl":null,"url":null,"abstract":"<div >The properties of a bioactive molecule are highly dependent on the precise arrangement of its constituent atoms. For example, altering the identity of a single atom in a heterocycle—a molecular ring containing at least one non-carbon element—can affect the efficacy of a drug. Although changing a single atom may sound easy, there are only a few reactions that enable such substitutions in complex organic molecules. Evaluating single-atom analogs for new therapeutic potential thus often requires laborious independent syntheses of each target structure. On page 99 of this issue, Kim <i>et al</i>. (<i>1</i>) report a simple photochemical reaction that exchanges an oxygen atom with a nitrogen in a heterocycle to produce a structural analog. This offers a powerful capability that could streamline chemical synthesis, transform complex molecules, and advance drug discovery.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6717","pages":""},"PeriodicalIF":45.8000,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science","FirstCategoryId":"103","ListUrlMain":"https://www.science.org/doi/10.1126/science.ads2595","RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
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Abstract
The properties of a bioactive molecule are highly dependent on the precise arrangement of its constituent atoms. For example, altering the identity of a single atom in a heterocycle—a molecular ring containing at least one non-carbon element—can affect the efficacy of a drug. Although changing a single atom may sound easy, there are only a few reactions that enable such substitutions in complex organic molecules. Evaluating single-atom analogs for new therapeutic potential thus often requires laborious independent syntheses of each target structure. On page 99 of this issue, Kim et al. (1) report a simple photochemical reaction that exchanges an oxygen atom with a nitrogen in a heterocycle to produce a structural analog. This offers a powerful capability that could streamline chemical synthesis, transform complex molecules, and advance drug discovery.
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