Therapeutic approaches targeting the gut microbiota in ischemic stroke: current advances and future directions.

IF 2.5 Q3 MICROBIOLOGY Bioscience of microbiota, food and health Pub Date : 2024-01-01 Epub Date: 2024-07-18 DOI:10.12938/bmfh.2024-022
Zhiguo Mao, Jinying Zhang, Lin Guo, Xiaoran Wang, Zhengwang Zhu, Mingsan Miao
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Abstract

Ischemic stroke (IS) is the predominant form of stroke pathology, and its clinical management remains constrained by therapeutic time frame. The gut microbiota (GM), comprising a multitude of bacterial and archaeal cells, surpasses the human cell count by approximately tenfold and significantly contributes to the human organism's growth, development, and overall well-being. The microbiota-gut-brain axis (MGBA) in recent years has established a strong association between gut microbes and the brain, demonstrating their intricate involvement in the progression of IS. The regulation of IS by the GM, encompassing changes in composition, abundance, and distribution, is multifaceted, involving neurological, endocrine, immunological, and metabolic mechanisms. This comprehensive understanding offers novel insights into the therapeutic approaches for IS. The objective of this paper is to examine the mechanisms of interaction between the GM and IS in recent years, assess the therapeutic effects of the GM on IS through various interventions, such as dietary modifications, probiotics, fecal microbiota transplantation, and antibiotics, and offer insights into the potential clinical application of the GM in stroke treatment.

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针对缺血性中风的肠道微生物群的治疗方法:当前进展与未来方向。
缺血性中风(IS)是中风的主要病理形式,其临床治疗仍然受到治疗时限的限制。肠道微生物群(GM)由大量细菌和古细菌细胞组成,其数量约为人体细胞数量的十倍,对人类机体的生长、发育和整体健康做出了重要贡献。近年来,微生物群-肠道-大脑轴(MGBA)建立了肠道微生物与大脑之间的紧密联系,证明它们在 IS 的发展过程中有着错综复杂的参与。肠道微生物群对 IS 的调控包括组成、丰度和分布的变化,是多方面的,涉及神经、内分泌、免疫和代谢机制。这种全面的认识为 IS 的治疗方法提供了新的视角。本文旨在研究近年来转基因与 IS 之间的相互作用机制,评估转基因通过各种干预措施(如饮食调整、益生菌、粪便微生物群移植和抗生素)对 IS 的治疗效果,并就转基因在中风治疗中的潜在临床应用提供见解。
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