Superwettable microchip for visual detection of date-rape drug in beverages

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL Sensors and Actuators B: Chemical Pub Date : 2024-10-04 DOI:10.1016/j.snb.2024.136737

Zhenping Li, Hao Xu, Yukun Du, Zhongyu Huang, Jing Li, Lian Liu, Ying Dong, Xiao-Yu Yang

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Abstract

Gamma-hydroxybutyric acid (GHB), which is used in drug-facilitated sexual assault, is typically delivered in the form of gamma-butyrolactone (GBL) in beverage carriers. In response to the growing need of methods for rapid and on-site sensing of the drugs, we carried out an investigation aimed at developing a superwettable microchip for visual detection of the date-rape drug GBL in adulterated beverages. The superwettable microchip is comprised of Fe₃O₄ nanoparticles which aggregate to form a reactive spot on a superhydrophobic fabric. The spot captures and confines microdroplets containing GBL on the superhydrophobic substrate. Fe(III), generated by HCl promoted reaction of the Fe₃O₄ spot, then participates in a colorimetric reaction with GBL to form a naked eye observable colored complex. Quantitative determination of GBL in beverages is achieved by analyzing the red proportion of a smartphone camera derived image. The detection range of this assay protocol is ca. 0.1-10 mg mL⁻¹, which meets the requirements to detect potentially dangerous concentration of GBL in drinks. The detection stability of the superwettable microchip for GBL in water and common beverages is maintained over at least 30 cycles.

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用于目视检测饮料中约会强奸药物的超润湿微芯片

γ-羟丁酸（GHB）被用于借助药物实施性侵犯，通常以γ-丁内酯（GBL）的形式存在于饮料载体中。为了满足对快速和现场感知药物的方法日益增长的需求，我们开展了一项调查，旨在开发一种超润湿微芯片，用于目视检测掺假饮料中的约会强奸药物 GBL。这种超润湿微芯片由 Fe3O4 纳米粒子组成，这些粒子聚集在超疏水织物上形成一个反应点。该点可捕获并限制超疏水基底上含有 GBL 的微滴。通过盐酸促进 Fe3O4 聚斑反应生成的铁（III）会与 GBL 发生比色反应，形成肉眼可见的彩色复合物。饮料中 GBL 的定量检测是通过分析智能手机摄像头生成的图像中的红色比例来实现的。该检测方案的检测范围约为 0.1-10 mg mL-1，符合检测饮料中具有潜在危险的 GBL 浓度的要求。超润湿微芯片对水和普通饮料中 GBL 的检测稳定性至少可以维持 30 个循环。

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来源期刊

Sensors and Actuators B: Chemical 工程技术-电化学

CiteScore

14.60

自引率

11.90%

发文量

1776

审稿时长

3.2 months

期刊介绍： Sensors & Actuators, B: Chemical is an international journal focused on the research and development of chemical transducers. It covers chemical sensors and biosensors, chemical actuators, and analytical microsystems. The journal is interdisciplinary, aiming to publish original works showcasing substantial advancements beyond the current state of the art in these fields, with practical applicability to solving meaningful analytical problems. Review articles are accepted by invitation from an Editor of the journal.