Wenyue Li, Junwei Cheng, Chuang Liu, Ni Zhang, Hua Lin, Fangfei He, Zhihua Gan, Peisen Zhang, Meng Qin, Yi Hou
{"title":"Shine and darkle the blood vessels: Multiparameter hypersensitive MR angiography for diagnosis of panvascular diseases","authors":"Wenyue Li, Junwei Cheng, Chuang Liu, Ni Zhang, Hua Lin, Fangfei He, Zhihua Gan, Peisen Zhang, Meng Qin, Yi Hou","doi":"10.1126/sciadv.adq4082","DOIUrl":null,"url":null,"abstract":"Magnetic resonance angiography (MRA) is pivotal for diagnosing panvascular diseases. However, single-modality MRA falls short in diagnosing diverse vascular abnormalities. Thus, contrast agents combining <jats:italic>T</jats:italic> <jats:sub>1</jats:sub> and <jats:italic>T</jats:italic> <jats:sub>2</jats:sub> effects are sought for multiparameter MRA with clinical promise, yet achieving a balance in <jats:italic>T</jats:italic> <jats:sub>1</jats:sub> and <jats:italic>T</jats:italic> <jats:sub>2</jats:sub> contrast enhancement effects remains a scientific challenge. Herein, we developed a hypersensitive multiparameter MRA strategy using dual-modality NaGdF <jats:sub>4</jats:sub> nanoparticles. Because of the longer tumbling time (τ <jats:sub>R</jats:sub> ), NaGdF <jats:sub>4</jats:sub> nanoparticles can improve the longitudinal relaxivity ( <jats:italic>r</jats:italic> <jats:sub>1</jats:sub> ), brightening vessels in <jats:italic>T</jats:italic> <jats:sub>1</jats:sub> -weighted sequences. Simultaneously, the regular arrangement of Gd <jats:sup>3+</jats:sup> in the crystal induces magnetic anisotropy, creating local static magnetic field heterogeneity and generating negative signals in <jats:italic>T</jats:italic> <jats:sub>2</jats:sub> -weighted sequences. Consequently, the efficacy of NaGdF <jats:sub>4</jats:sub> -enhanced high-resolution multiparameter MRA has been validated in diagnosing ischemic stroke and Alzheimer’s disease in rodent models. In addition, the dual-contrast imaging has been realized on swine with a clinical 3.0-T magnetic resonance imaging scanner, highly emphasizing the clinical translation prospect.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":null,"pages":null},"PeriodicalIF":11.7000,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science Advances","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.1126/sciadv.adq4082","RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Magnetic resonance angiography (MRA) is pivotal for diagnosing panvascular diseases. However, single-modality MRA falls short in diagnosing diverse vascular abnormalities. Thus, contrast agents combining T1 and T2 effects are sought for multiparameter MRA with clinical promise, yet achieving a balance in T1 and T2 contrast enhancement effects remains a scientific challenge. Herein, we developed a hypersensitive multiparameter MRA strategy using dual-modality NaGdF 4 nanoparticles. Because of the longer tumbling time (τ R ), NaGdF 4 nanoparticles can improve the longitudinal relaxivity ( r1 ), brightening vessels in T1 -weighted sequences. Simultaneously, the regular arrangement of Gd 3+ in the crystal induces magnetic anisotropy, creating local static magnetic field heterogeneity and generating negative signals in T2 -weighted sequences. Consequently, the efficacy of NaGdF 4 -enhanced high-resolution multiparameter MRA has been validated in diagnosing ischemic stroke and Alzheimer’s disease in rodent models. In addition, the dual-contrast imaging has been realized on swine with a clinical 3.0-T magnetic resonance imaging scanner, highly emphasizing the clinical translation prospect.
期刊介绍:
Science Advances, an open-access journal by AAAS, publishes impactful research in diverse scientific areas. It aims for fair, fast, and expert peer review, providing freely accessible research to readers. Led by distinguished scientists, the journal supports AAAS's mission by extending Science magazine's capacity to identify and promote significant advances. Evolving digital publishing technologies play a crucial role in advancing AAAS's global mission for science communication and benefitting humankind.