Biosynthesis of oxindole alkaloids: Recent advances and challenges

IF 8.3 2区 生物学 Q1 PLANT SCIENCES Current opinion in plant biology Pub Date : 2024-10-03 DOI:10.1016/j.pbi.2024.102648
Ana C. Ramos-Valdivia , Carlos M. Cerda-García-Rojas
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Abstract

The monoterpenoid oxindole alkaloids (MOA) are specialized plant metabolites of pharmacological importance, whose biosynthesis is linked to a unique oxidative process of monoterpenoid indole alkaloids (MIA). These transformations arise from complex biosynthetic pathways defined by species, organs, tissues, and growth stages. Initial studies of their biosynthesis using labeled precursors date back more than five decades ago. This review shows the advances in this topic within the years 2022–2023, which highlight the research by integrative omics strategies, validating previously stated hypotheses. The MOA biosynthesis pathway is beginning to be elucidated, especially in the early and intermediate stages starting from MIA. Also, progress in the characterization of enzymes that regulate the process has been made. The discovery of a key enzyme in the formation of the spirooxindole scaffold represents a starting point for an enormous amount of work that remains to be done to clarify and understand the formation mechanisms of MOA.
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吲哚生物碱的生物合成:最新进展与挑战。
单萜吲哚生物碱(MOA)是具有重要药理作用的特殊植物代谢产物,其生物合成与单萜吲哚生物碱(MIA)的独特氧化过程有关。这些转化产生于不同物种、器官、组织和生长阶段的复杂生物合成途径。利用标记前体对其生物合成的初步研究可追溯到五十多年前。这篇综述展示了 2022-2023 年这一主题的研究进展,其中突出强调了通过综合全息策略进行的研究,验证了之前提出的假设。MOA的生物合成途径已开始被阐明,特别是从MIA开始的早期和中期阶段。此外,对调节该过程的酶的特征描述也取得了进展。螺吲哚支架形成过程中一种关键酶的发现是一个起点,要阐明和了解 MOA 的形成机制,还有大量工作要做。
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来源期刊
Current opinion in plant biology
Current opinion in plant biology 生物-植物科学
CiteScore
16.30
自引率
3.20%
发文量
131
审稿时长
6-12 weeks
期刊介绍: Current Opinion in Plant Biology builds on Elsevier's reputation for excellence in scientific publishing and long-standing commitment to communicating high quality reproducible research. It is part of the Current Opinion and Research (CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy - of editorial excellence, high-impact, and global reach - to ensure they are a widely read resource that is integral to scientists' workflow.
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