Probing the oral-brain connection: oral microbiome patterns in a large community cohort with anxiety, depression, and trauma symptoms, and periodontal outcomes.

IF 5.8 1区 医学 Q1 PSYCHIATRY Translational Psychiatry Pub Date : 2024-10-05 DOI:10.1038/s41398-024-03122-4
Stefanie Malan-Müller, Rebeca Vidal, Esther O'Shea, Eduardo Montero, Elena Figuero, Iñaki Zorrilla, Javier de Diego-Adeliño, Marta Cano, Maria Paz García-Portilla, Ana González-Pinto, Juan C Leza
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Abstract

The role of the oral microbiome in mental health has recently been appreciated within the proposed oral-brain axis. This study examined the structure and composition of the salivary microbiome in a large-scale population-based cohort of individuals reporting mental health symptoms (n = 306) compared to mentally healthy controls (n = 164) using 16S rRNA sequencing. Mental health symptoms were evaluated using validated questionnaires and included depression, anxiety, and posttraumatic stress disorder (PTSD), with accompanying periodontal outcomes. Participants also indicated current or previous diagnoses of anxiety, depression, periodontitis, and gingivitis. Mental and periodontal health variables influenced the overall composition of the oral microbiome. PTSD symptoms correlated with a lower clr-transformed relative abundance of Haemophilus sputorum and a higher clr-transformed relative abundance of Prevotella histicola. The clr-transformed relative abundance of P. histicola was also positively associated with depressive scores and negatively associated with psychological quality of life. Anxiety disorder diagnosis was associated with a lower clr-transformed relative abundance of Neisseria elongate and a higher clr-transformed relative abundance of Oribacterium asaccharolyticum. A higher clr-transformed relative abundance of Shuttleworthia and lower clr-transformed relative abundance of Capnocytophaga were evident in those who reported a clinical periodontitis diagnosis. Higher Eggerthia and lower Haemophilus parainfluenzae clr-transformed relative abundances were associated with reported clinical periodontitis diagnoses and psychotherapeutic efficacy. Functional prediction analysis revealed a potential role for tryptophan metabolism/degradation in the oral-brain axis, which was confirmed by lower plasma serotonin levels across symptomatic groups. This study sheds light on the intricate interplay between oral microbiota, periodontal and mental health outcomes, and a potential role for tryptophan metabolism in the proposed oral-brain axis, emphasizing the need for further exploration to pave the way for novel therapeutic interventions and predicting therapeutic response.

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探究口腔与大脑的联系:具有焦虑、抑郁和创伤症状的大型社区队列中的口腔微生物组模式以及牙周结果。
口腔微生物组在心理健康中的作用最近在拟议的口腔-大脑轴中得到了重视。本研究利用 16S rRNA 测序技术,对一个大规模人群队列中的唾液微生物组的结构和组成进行了研究,该人群队列中报告有精神健康症状的人(n = 306)与精神健康的对照组(n = 164)进行了比较。心理健康症状通过有效问卷进行评估,包括抑郁症、焦虑症和创伤后应激障碍(PTSD),以及相应的牙周症状。受试者还表示目前或以前曾被诊断患有焦虑症、抑郁症、牙周炎和牙龈炎。精神和牙周健康变量影响着口腔微生物组的整体组成。创伤后应激障碍症状与较低的唾液嗜血杆菌clr转换相对丰度和较高的组织前孢子菌clr转换相对丰度相关。组织胞浆菌的clr转换相对丰度也与抑郁评分呈正相关,与心理生活质量呈负相关。焦虑症诊断与较低的细长奈瑟氏菌clr转化相对丰度和较高的asaccharolyticum变形杆菌clr转化相对丰度有关。在报告临床牙周炎诊断的人群中,Shuttleworthia 的 clr 转化相对丰度较高,Capnocytophaga 的 clr 转化相对丰度较低。较高的Eggerthia和较低的副流感嗜血杆菌clr-转化相对丰度与报告的临床牙周炎诊断和心理治疗效果有关。功能预测分析揭示了色氨酸代谢/降解在口腔-大脑轴中的潜在作用,症状组血浆血清素水平较低也证实了这一点。这项研究揭示了口腔微生物群、牙周和心理健康结果之间错综复杂的相互作用,以及色氨酸代谢在拟议的口腔-大脑轴中的潜在作用,强调了进一步探索的必要性,以便为新型治疗干预和预测治疗反应铺平道路。
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来源期刊
CiteScore
11.50
自引率
2.90%
发文量
484
审稿时长
23 weeks
期刊介绍: Psychiatry has suffered tremendously by the limited translational pipeline. Nobel laureate Julius Axelrod''s discovery in 1961 of monoamine reuptake by pre-synaptic neurons still forms the basis of contemporary antidepressant treatment. There is a grievous gap between the explosion of knowledge in neuroscience and conceptually novel treatments for our patients. Translational Psychiatry bridges this gap by fostering and highlighting the pathway from discovery to clinical applications, healthcare and global health. We view translation broadly as the full spectrum of work that marks the pathway from discovery to global health, inclusive. The steps of translation that are within the scope of Translational Psychiatry include (i) fundamental discovery, (ii) bench to bedside, (iii) bedside to clinical applications (clinical trials), (iv) translation to policy and health care guidelines, (v) assessment of health policy and usage, and (vi) global health. All areas of medical research, including — but not restricted to — molecular biology, genetics, pharmacology, imaging and epidemiology are welcome as they contribute to enhance the field of translational psychiatry.
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