The Potential Role of Cannabidiol in Cosmetic Dermatology: A Literature Review

IF 8.6 1区医学 Q1 DERMATOLOGY American Journal of Clinical Dermatology Pub Date : 2024-10-05 DOI:10.1007/s40257-024-00891-y

Ai Kuzumi, Asako Yoshizaki-Ogawa, Takemichi Fukasawa, Shinichi Sato, Ayumi Yoshizaki

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Abstract

Cannabidiol (CBD) is a non-psychotropic cannabinoid with multiple pharmacological properties. Cannabidiol has attracted growing attention in the cosmetic industry, with an increasing number of CBD-containing skincare products on the market in recent years. The aim of this review is to evaluate the current evidence on the use of CBD for cosmetic purposes. Following an overview of CBD and the endocannabinoid system in the skin, we summarize pre-clinical and clinical studies that address the potential of CBD in cosmetic dermatology. Available in vitro and in vivo evidence suggests that CBD has anti-oxidant, anti-inflammatory, moisturizing, anti-acne, wound-healing, and anti-aging properties. However, only a few clinical studies have been conducted on the use of CBD in the skin. In addition, there is a critical need to develop an efficient drug-delivery system for topical/transdermal application of CBD. Further research, including clinical and pharmacokinetic studies, are needed to fully evaluate the role of CBD in cosmetic dermatology.

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大麻二酚在皮肤美容中的潜在作用：文献综述。

大麻二酚（CBD）是一种非精神类大麻素，具有多种药理特性。近年来，随着市场上含有 CBD 的护肤品越来越多，大麻二酚在化妆品行业引起了越来越多的关注。本综述旨在评估目前将 CBD 用于美容目的的证据。在概述了 CBD 和皮肤中的内源性大麻素系统之后，我们总结了有关 CBD 在皮肤美容方面的潜力的临床前和临床研究。现有的体外和体内证据表明，CBD 具有抗氧化、抗炎、保湿、抗痤疮、伤口愈合和抗衰老等特性。然而，只有少数临床研究对 CBD 在皮肤中的应用进行了研究。此外，亟需开发一种高效的药物输送系统，用于 CBD 的局部/透皮应用。要全面评估 CBD 在皮肤美容方面的作用，还需要进一步的研究，包括临床和药代动力学研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Clinical Dermatology 医学-皮肤病学

CiteScore

15.20

自引率

2.70%

发文量

审稿时长

>12 weeks

期刊介绍： The American Journal of Clinical Dermatology is dedicated to evidence-based therapy and effective patient management in dermatology. It publishes critical review articles and clinically focused original research covering comprehensive aspects of dermatological conditions. The journal enhances visibility and educational value through features like Key Points summaries, plain language summaries, and various digital elements, ensuring accessibility and depth for a diverse readership.